Abstract
Hepatocellular carcinoma (HCC) is a major worldwide health concern with an increasing incidence in the United States. Orthotopic liver transplantation (OLT) has been established as the gold standard for curative therapy of HCC. Because of limited organ supply and socioeconomic factors, OLT is often not a viable option. Surgical resection and ablation are also effective for providing long-term survival. However, most patients are ineligible for curative surgical therapy due to advanced disease. For these patients, effective treatment options have been lacking. Systemic chemotherapy and even recent biologic, targeted agents have shown little to minimal efficacy. Liver-directed regional therapies, including trans-arterial chemoembolization (TACE) and selective internal radiation treatment (SIRT) with Yttrium-90 radioembolization have emerged in recent years as effective therapies to provide local control of disease. Randomized trials have demonstrated a survival benefit for TACE, and SIRT has shown efficacy as an embolic alternative to TACE. Here we review the experience of liver-directed regional therapies and provide a clear rationale for their implementation in a multi-disciplinary algorithmic approach to the management of HCC.
Keywords: Liver-directed therapy, regional therapy, hepatocellular cancer, chemoembolization, radioembolization
Current Cancer Therapy Reviews
Title: Liver-Directed Regional Therapy in the Multi-Disciplinary Management of Hepatocellular Cancer
Volume: 6 Issue: 1
Author(s): Maheswari Senthil, Brian Mailey, Lucille Leong, Vincent Chung, Yun Yen, Yi-Jen Chen, Howard Marx and Joseph Kim
Affiliation:
Keywords: Liver-directed therapy, regional therapy, hepatocellular cancer, chemoembolization, radioembolization
Abstract: Hepatocellular carcinoma (HCC) is a major worldwide health concern with an increasing incidence in the United States. Orthotopic liver transplantation (OLT) has been established as the gold standard for curative therapy of HCC. Because of limited organ supply and socioeconomic factors, OLT is often not a viable option. Surgical resection and ablation are also effective for providing long-term survival. However, most patients are ineligible for curative surgical therapy due to advanced disease. For these patients, effective treatment options have been lacking. Systemic chemotherapy and even recent biologic, targeted agents have shown little to minimal efficacy. Liver-directed regional therapies, including trans-arterial chemoembolization (TACE) and selective internal radiation treatment (SIRT) with Yttrium-90 radioembolization have emerged in recent years as effective therapies to provide local control of disease. Randomized trials have demonstrated a survival benefit for TACE, and SIRT has shown efficacy as an embolic alternative to TACE. Here we review the experience of liver-directed regional therapies and provide a clear rationale for their implementation in a multi-disciplinary algorithmic approach to the management of HCC.
Export Options
About this article
Cite this article as:
Senthil Maheswari, Mailey Brian, Leong Lucille, Chung Vincent, Yen Yun, Chen Yi-Jen, Marx Howard and Kim Joseph, Liver-Directed Regional Therapy in the Multi-Disciplinary Management of Hepatocellular Cancer, Current Cancer Therapy Reviews 2010; 6 (1) . https://dx.doi.org/10.2174/157339410790596461
DOI https://dx.doi.org/10.2174/157339410790596461 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
Call for Papers in Thematic Issues
Current progress in Protein Degradation and Cancer Therapy
argeted Protein Degradation is gaining momentum in cancer therapy, it facilitate targeting undruggable proteins, it overcome cancer resistance and avoid undesirable side effects. Thus small molecules degraders have emerged as novel therapeutic strategy. Targeted protein degradation (TPD), the process of eliminating a protein of interest hold a great promise for ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
An Overview of Nanoformulated Nutraceuticals and their Therapeutic Approaches
Current Nutrition & Food Science Contribution of Canalicular Glutathione Efflux to Bile Formation. From Cholestasis Associated Alterations to Pharmacological Intervention to Modify Bile Flow
Current Drug Targets - Immune, Endocrine & Metabolic Disorders LRRC4 Inhibits Glioma Cell Growth and Invasion Through a miR-185- Dependent Pathway
Current Cancer Drug Targets Nongenomic Actions of Retinoids: Role of Nur77 and RXR in the Regulation of Apoptosis and Inflammation
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry New Approaches to Postoperative Radiotherapy for Cancer of the Head and Neck
Current Cancer Therapy Reviews Radioiodinated Agents for Imaging Multidrug Resistant Tumors
Medicinal Chemistry Hepatocarcinogenesis and Ceramide/Cholesterol Metabolism
Anti-Cancer Agents in Medicinal Chemistry Active Targeting Strategies for Anticancer Drug Nanocarriers
Current Drug Delivery Fluoride Interactions: From Molecules to Disease
Current Signal Transduction Therapy Poly(Ethylene Glycol) Amphiphilic Copolymer for Anticancer Drugs Delivery
Anti-Cancer Agents in Medicinal Chemistry Targeting Tumor Immunosuppressive Microenvironment for the Prevention of Hepatic Cancer: Applications of Traditional Chinese Medicines in Targeted Delivery
Current Topics in Medicinal Chemistry Advances in Chemotherapy and Targeted Systemic Therapies for Urothelial Cancer
Current Drug Therapy The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress
Current Molecular Medicine Bone Disruption and Environmental Pollutants
Endocrine, Metabolic & Immune Disorders - Drug Targets PET Imaging for Gene & Cell Therapy
Current Gene Therapy Recent Advances in Optical Molecular Imaging and its Applications in Targeted Drug Delivery
Current Drug Targets Animal Mitochondria: Evolution, Function, and Disease
Current Molecular Medicine Oncogene-Blocking Therapies: New Insights from Conditional Mouse Tumor Models
Current Cancer Drug Targets C-11 Radiochemistry in Cancer Imaging Applications
Current Topics in Medicinal Chemistry Regulation of EMT by KLF4 in Gastrointestinal Cancer
Current Cancer Drug Targets