Abstract
The formation of advanced glycation end-products (AGEs), also called the Maillard reaction, occurs ubiquitously and irreversibly in patients with diabetes mellitus and its consequences are especially relevant to many inflammatory events leading to vascular dysfunctions and organ injury. The present review intends to highlight some relevant aspects of nitric oxide synthases, advanced glycation end-products and their receptors as well as the mechanisms by which AGEs are able to modulate the synthesis of nitric oxide (NO), either by NO quenching, modification of enzyme structure or regulation of gene expression. Finally, other RAGE ligands different from AGEs, but relevant to the context of inflammation, are presented as new modulators of nitric oxide synthesis.
Keywords: Advanced glycation, nitric oxide synthases, diabetic complications, hyperglycemia, inflammation, receptor for advanced glycation end-products, RAGE, ligands
Current Enzyme Inhibition
Title: Modulation of Nitric Oxide Pathway by Multiligands/RAGE Axis: A Crossing Point on the Road to Microvascular Complication in Diabetes
Volume: 6 Issue: 1
Author(s): Armando Rojas, Deyarina Gonzalez, Hector Figueroa, Miguel A. Morales and Jacqueline Romero
Affiliation:
Keywords: Advanced glycation, nitric oxide synthases, diabetic complications, hyperglycemia, inflammation, receptor for advanced glycation end-products, RAGE, ligands
Abstract: The formation of advanced glycation end-products (AGEs), also called the Maillard reaction, occurs ubiquitously and irreversibly in patients with diabetes mellitus and its consequences are especially relevant to many inflammatory events leading to vascular dysfunctions and organ injury. The present review intends to highlight some relevant aspects of nitric oxide synthases, advanced glycation end-products and their receptors as well as the mechanisms by which AGEs are able to modulate the synthesis of nitric oxide (NO), either by NO quenching, modification of enzyme structure or regulation of gene expression. Finally, other RAGE ligands different from AGEs, but relevant to the context of inflammation, are presented as new modulators of nitric oxide synthesis.
Export Options
About this article
Cite this article as:
Rojas Armando, Gonzalez Deyarina, Figueroa Hector, Morales A. Miguel and Romero Jacqueline, Modulation of Nitric Oxide Pathway by Multiligands/RAGE Axis: A Crossing Point on the Road to Microvascular Complication in Diabetes, Current Enzyme Inhibition 2010; 6 (1) . https://dx.doi.org/10.2174/157340810790712050
DOI https://dx.doi.org/10.2174/157340810790712050 |
Print ISSN 1573-4080 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6662 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
A Glimpse of Matrix Metalloproteinases in Diabetic Nephropathy
Current Medicinal Chemistry Multitasking of Neuropeptide Y through the Lens of Motifs
Recent Patents on CNS Drug Discovery (Discontinued) Healing the Diabetic Heart: Modulation of Cardiometabolic Syndrome through Peroxisome Proliferator Activated Receptors (PPARs)
Current Molecular Pharmacology Human Pluripotent Stem Cells for Modelling Human Liver Diseases and Cell Therapy
Current Gene Therapy Will Antirheumatic Treatment Improve Cardiovascular Outcomes in Patients with Rheumatoid Arthritis?
Current Pharmaceutical Design Pre-eclampsia Versus Cardiovascular Disease Versus CRP
Current Hypertension Reviews Polymorphism rs9939609 of Fat Mass and Obesity-associated Gene Correlation with Leptin Level of Obese Women Suffered from Type 2 Diabetes
Current Diabetes Reviews A Knock-Down Cell-Based Study for the Functional Analysis of Chloride Intracellular Channel 1 (CLIC1): Integrated Proteomics and Microarray Study
Protein & Peptide Letters Synthesis and Immunosuppressive Activity of New Mycophenolic Acid Derivatives
Medicinal Chemistry Arthritis and Periodontitis: An Association Debated for Over Two Centuries
Current Rheumatology Reviews Targeting PPAR Isoforms Following CNS Injury
Current Drug Targets The Effect of Stress Management Program on Perceived Stress in Patients with Type 2 Diabetes: A Randomized Controlled Trial
Current Diabetes Reviews Antiplatelet Therapy And Percutaneous Coronary Interventions
Current Cardiology Reviews Nutrition and Physical Activity on Hypertension: Implication of Current Evidence and Guidelines
Current Hypertension Reviews Enriching One’s Environment in the Face of Cognitive and Functional Loss
Current Neurovascular Research From Pharmacotherapy to Pathophysiology: Emerging Mechanisms of Apolipoprotein D in Psychiatric Disorders
Current Molecular Medicine The Importance of Early Diagnosis and Treatment in Peripheral Arterial Disease: Insights from the PARTNERS and REACH Registries
Current Vascular Pharmacology An Emerging Strategy for Cancer Treatment Targeting Aberrant Glycogen Synthase Kinase 3β
Anti-Cancer Agents in Medicinal Chemistry Disease-Induced Neuroinflammation and Depression
CNS & Neurological Disorders - Drug Targets Dry Age-Related Macular Degeneration: Recent Progress of Therapeutic approaches
Current Molecular Pharmacology