Abstract
The poisoning with organophosphorus compounds represents a life threatening danger especially in the time of terroristic menace. No universal antidote has been developed yet and other therapeutic approaches not related to reactivation of acetylcholinesterase are being investigated. This review describes the main features of the cholinergic system, cholinergic receptors, cholinesterases and their inhibitors. It also focuses on the organophosphorus nerve agents, their properties, effects and a large part describes various possibilities in treatments, mainly traditional oxime therapies based on reactivation of AChE. Furthermore, non-cholinesterase coupled antidotal effects of the oximes are thoroughly discussed. These antidotal effects principally include oxime interactions with muscarinic and nicotinic receptors.
Keywords: Acetylcholinesterase, muscarinic receptors, nicotinic receptors, antidotes, nerve agents, ogranophosphates, cholinergic system
Current Medicinal Chemistry
Title: Interaction of Nerve Agent Antidotes with Cholinergic Systems
Volume: 17 Issue: 16
Author(s): O. Soukup, G. Tobin, U.K. Kumar, J. Binder, J. Proska, D. Jun, J. Fusek and K. Kuca
Affiliation:
Keywords: Acetylcholinesterase, muscarinic receptors, nicotinic receptors, antidotes, nerve agents, ogranophosphates, cholinergic system
Abstract: The poisoning with organophosphorus compounds represents a life threatening danger especially in the time of terroristic menace. No universal antidote has been developed yet and other therapeutic approaches not related to reactivation of acetylcholinesterase are being investigated. This review describes the main features of the cholinergic system, cholinergic receptors, cholinesterases and their inhibitors. It also focuses on the organophosphorus nerve agents, their properties, effects and a large part describes various possibilities in treatments, mainly traditional oxime therapies based on reactivation of AChE. Furthermore, non-cholinesterase coupled antidotal effects of the oximes are thoroughly discussed. These antidotal effects principally include oxime interactions with muscarinic and nicotinic receptors.
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Cite this article as:
Soukup O., Tobin G., Kumar U.K., Binder J., Proska J., Jun D., Fusek J. and Kuca K., Interaction of Nerve Agent Antidotes with Cholinergic Systems, Current Medicinal Chemistry 2010; 17 (16) . https://dx.doi.org/10.2174/092986710791111260
DOI https://dx.doi.org/10.2174/092986710791111260 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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