Abstract
Single-walled carbon nanotubes (SWNTs), a member of the carbon family, are the one-dimensional analogues of zero-dimensional fullerene molecules with unique structural and electronic properties. Since the discovery of SWNTs, they have been extensively studied for biomedical applications. In biological media SWNTs have unique near-infrared intrinsic fluorescence, inherent Raman spectroscopy and photoacoustic signal associated with the graphene in SWNTs which makes them ideal for noninvasive and high sensitivity detection. SWNTs have been broadly investigated as imaging agents for the evaluation of tumor targeting and localization of SWNTs in vitro and in vivo. Rational functionalization can also endow SWNTs with desired properties for biomedical applications. Functionalized SWNTs with significantly reduced toxicity have been employed as carriers to deliver various anticancer drugs, proteins and nucleic acids to the diseased tissues specifically and maximize the bioavailability of the drugs by improving solubility and increasing circulation time. This manuscript will highlight the recent employment of SWNTs in the field of nanomedicine and bioimaging, and also outline the challenges and future opportunities for biomedical applications of SWNTs.
Keywords: Carbon nanotubes, CNTs dispersion, biocompatibility, drug delivery, molecular imaging
Current Medicinal Chemistry
Title: A Review on Biomedical Applications of Single-Walled Carbon Nanotubes
Volume: 17 Issue: 1
Author(s): F. Liang and B. Chen
Affiliation:
Keywords: Carbon nanotubes, CNTs dispersion, biocompatibility, drug delivery, molecular imaging
Abstract: Single-walled carbon nanotubes (SWNTs), a member of the carbon family, are the one-dimensional analogues of zero-dimensional fullerene molecules with unique structural and electronic properties. Since the discovery of SWNTs, they have been extensively studied for biomedical applications. In biological media SWNTs have unique near-infrared intrinsic fluorescence, inherent Raman spectroscopy and photoacoustic signal associated with the graphene in SWNTs which makes them ideal for noninvasive and high sensitivity detection. SWNTs have been broadly investigated as imaging agents for the evaluation of tumor targeting and localization of SWNTs in vitro and in vivo. Rational functionalization can also endow SWNTs with desired properties for biomedical applications. Functionalized SWNTs with significantly reduced toxicity have been employed as carriers to deliver various anticancer drugs, proteins and nucleic acids to the diseased tissues specifically and maximize the bioavailability of the drugs by improving solubility and increasing circulation time. This manuscript will highlight the recent employment of SWNTs in the field of nanomedicine and bioimaging, and also outline the challenges and future opportunities for biomedical applications of SWNTs.
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Cite this article as:
Liang F. and Chen B., A Review on Biomedical Applications of Single-Walled Carbon Nanotubes, Current Medicinal Chemistry 2010; 17 (1) . https://dx.doi.org/10.2174/092986710789957742
DOI https://dx.doi.org/10.2174/092986710789957742 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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