Abstract
The immune system balances effector responses with tolerance, to protect the host from pathogens while minimizing local damage to tissue. An altered control of immune homeostasis can lead to loss of tolerance to self antigens in autoimmunity, or promote unwanted tolerance to tumor growth. This review focuses on the dual activity of CD4+ regulatory T cells (Tregs) in autoimmunity and cancer. Tregs play a key role in the mechanisms of immune tolerance and actively suppress pro-inflammatory responses, thus providing a beneficial action in autoimmunity and detrimental effects in cancer.
Keywords: CD4+, T Cells, immune system, homeostasis
Current Medicinal Chemistry
Title: The Yin and Yang of CD4+ Regulatory T Cells in Autoimmunity and Cancer
Volume: 16 Issue: 35
Author(s): M. Galgani, A. Di Giacomo, G. Matarese and A. La Cava
Affiliation:
Keywords: CD4+, T Cells, immune system, homeostasis
Abstract: The immune system balances effector responses with tolerance, to protect the host from pathogens while minimizing local damage to tissue. An altered control of immune homeostasis can lead to loss of tolerance to self antigens in autoimmunity, or promote unwanted tolerance to tumor growth. This review focuses on the dual activity of CD4+ regulatory T cells (Tregs) in autoimmunity and cancer. Tregs play a key role in the mechanisms of immune tolerance and actively suppress pro-inflammatory responses, thus providing a beneficial action in autoimmunity and detrimental effects in cancer.
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Cite this article as:
Galgani M., Di Giacomo A., Matarese G. and Cava La A., The Yin and Yang of CD4+ Regulatory T Cells in Autoimmunity and Cancer, Current Medicinal Chemistry 2009; 16 (35) . https://dx.doi.org/10.2174/092986709789878201
DOI https://dx.doi.org/10.2174/092986709789878201 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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