Generic placeholder image

Anti-Cancer Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Cytotoxic Compounds in the Treatment of Castration-Resistant Prostate Cancer

Author(s): Patrick Lee and Jeanny B. Aragon-Ching

Volume 9, Issue 10, 2009

Page: [1040 - 1045] Pages: 6

DOI: 10.2174/187152009789734991

Price: $65

Abstract

Prostate cancer is the most common non-cutaneous cancer among men in the United States. Most will be diagnosed at an early stage, but a significant number will still develop metastatic castration resistant disease. Docetaxel has demonstrated improved quality of life and overall survival in metastatic castration-resistant prostate cancer but virtually all patients will ultimately become refractory to taxane therapy. Second-line options are limited and new effective chemotherapeutic agents or combinations are needed in this setting. This review will focus on cytotoxic compounds in clinical investigation either in combination with taxanes in the first or second-line setting and other novel compounds, such as platinums and microtubule-targeting agents that are in active clinical investigation.

Keywords: Chemotherapy, platinum, docetaxel, microtubule-targeting agents, epothilones, prostate cancer


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy