Abstract
The heat shock protein (HSP) family has long been associated with a generalized cellular stress response, particularly in terms of recognizing and chaperoning misfolded proteins. While HSPs in general appear to be protective, HSP27 has recently emerged as a particularly potent neuroprotectant in a number of diverse neurological disorders, ranging from ALS to stroke. Although its robust protective effect on a number of insults has been recognized, the mechanisms and regulation of HSP27s protective actions are still undergoing intense investigation. On the basis of recent studies, HSP27 appears to have a dynamic and diverse range of function in cellular survival. This review provides a forum to compare and contrast recent literature exploring the protective mechanism and regulation of HSP27, focusing on neurological disorders in particular, as they represent a range from protein aggregate-associated diseases to acute stress.
Keywords: HSP27, heat shock proteins, chaperones, ischemia, aggregates, injury
Current Molecular Medicine
Title: HSP27: Mechanisms of Cellular Protection Against Neuronal Injury
Volume: 9 Issue: 7
Author(s): R. A. Stetler, Y. Gao, A. P. Signore, G. Cao and J. Chen
Affiliation:
Keywords: HSP27, heat shock proteins, chaperones, ischemia, aggregates, injury
Abstract: The heat shock protein (HSP) family has long been associated with a generalized cellular stress response, particularly in terms of recognizing and chaperoning misfolded proteins. While HSPs in general appear to be protective, HSP27 has recently emerged as a particularly potent neuroprotectant in a number of diverse neurological disorders, ranging from ALS to stroke. Although its robust protective effect on a number of insults has been recognized, the mechanisms and regulation of HSP27s protective actions are still undergoing intense investigation. On the basis of recent studies, HSP27 appears to have a dynamic and diverse range of function in cellular survival. This review provides a forum to compare and contrast recent literature exploring the protective mechanism and regulation of HSP27, focusing on neurological disorders in particular, as they represent a range from protein aggregate-associated diseases to acute stress.
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Cite this article as:
Stetler A. R., Gao Y., Signore P. A., Cao G. and Chen J., HSP27: Mechanisms of Cellular Protection Against Neuronal Injury, Current Molecular Medicine 2009; 9 (7) . https://dx.doi.org/10.2174/156652409789105561
DOI https://dx.doi.org/10.2174/156652409789105561 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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