Abstract
The L-type Ca2+ channel plays a critical role in cardiac function as the main route for entry of calcium into cardiac myocytes. It is essential to excitability as it shapes the long plateau phase of the cardiac action potential that is unique to cardiac ventricular myocytes. It is necessary for contraction as it triggers the release of calcium from sarcoplasmic reticulum stores for actin-myosin interaction. The L-type Ca2+ channel also regulates cytoplasmic calcium levels. It is well recognized that an increase in intracellular calcium is involved in the activation of growth-promoting signal pathways. Recently, reactive oxygen species have been implicated in the activation of signal pathways and the development of pathological hypertrophy. There is now evidence that implicates activation of the L-type Ca2+ channel with persistent alterations in calcium homeostasis and cellular reactive oxygen species production as a possible trigger of cardiac hypertrophy. A number of different approaches have been used to modify channel function with the view to preventing ischemiareperfusion injury, cardiac hypertrophy or cardiac failure providing good evidence that the L-type Ca2+ channel may be an efficacious target in the prevention of cardiac pathology.
Keywords: L-type Ca2+ channel, calcium homeostasis, reactive oxygen species, cardiac hypertrophy, L-type Ca2+ channel antagonists
Current Medicinal Chemistry
Title: The L-Type Ca2+ Channel as a Therapeutic Target in Heart Disease
Volume: 16 Issue: 26
Author(s): H. M. Viola, W. A. Macdonald, H. Tang and L. C. Hool
Affiliation:
Keywords: L-type Ca2+ channel, calcium homeostasis, reactive oxygen species, cardiac hypertrophy, L-type Ca2+ channel antagonists
Abstract: The L-type Ca2+ channel plays a critical role in cardiac function as the main route for entry of calcium into cardiac myocytes. It is essential to excitability as it shapes the long plateau phase of the cardiac action potential that is unique to cardiac ventricular myocytes. It is necessary for contraction as it triggers the release of calcium from sarcoplasmic reticulum stores for actin-myosin interaction. The L-type Ca2+ channel also regulates cytoplasmic calcium levels. It is well recognized that an increase in intracellular calcium is involved in the activation of growth-promoting signal pathways. Recently, reactive oxygen species have been implicated in the activation of signal pathways and the development of pathological hypertrophy. There is now evidence that implicates activation of the L-type Ca2+ channel with persistent alterations in calcium homeostasis and cellular reactive oxygen species production as a possible trigger of cardiac hypertrophy. A number of different approaches have been used to modify channel function with the view to preventing ischemiareperfusion injury, cardiac hypertrophy or cardiac failure providing good evidence that the L-type Ca2+ channel may be an efficacious target in the prevention of cardiac pathology.
Export Options
About this article
Cite this article as:
Viola M. H., Macdonald A. W., Tang H. and Hool C. L., The L-Type Ca2+ Channel as a Therapeutic Target in Heart Disease, Current Medicinal Chemistry 2009; 16 (26) . https://dx.doi.org/10.2174/092986709789057671
DOI https://dx.doi.org/10.2174/092986709789057671 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Effects of Structured Treatment Interruptions on Metabolic, Anthropometric, Immunologic, and Quality of Life Outcomes in HIV-Positive Adults on HAART
Current HIV Research Multi-Modality Cardiac Imaging in Interventional Cardiology
Current Medical Imaging Resveratrol: New Avenues for a Natural Compound in Neuroprotection
Current Pharmaceutical Design Effects of Thiazolidinediones Beyond Glycaemic Control
Current Pharmaceutical Design Clinical Utility of Acarbose, an α-Glucosidase Inhibitor in Cardiometabolic Disorders
Current Drug Metabolism The Diagnostic and Prognostic Value of Brain Natriuretic Peptide and Aminoterminal (nt)-pro Brain Natriuretic Peptide
Current Pharmaceutical Design Coarctation of the Aorta - An Evolution of Therapeutic Options
Current Cardiology Reviews Antiarrhythmic Therapy on Prevention of Postoperative Atrial Fibrillation in Patients After Heart Surgery
Current Medicinal Chemistry - Cardiovascular & Hematological Agents Molecular Modeling Investigation of Folic Acid Conjugation to MDM2 Inhibitors for Enhanced Cellular Uptake and Target Binding
Current Computer-Aided Drug Design Ontologies of Drug Discovery and Design for Neurology, Cardiology and Oncology
Current Pharmaceutical Design The Metabolomic Strategy in Tuberculosis Therapy
Combinatorial Chemistry & High Throughput Screening Subject Index to Volume 2
Current Vascular Pharmacology Thromboxane A<sub>2</sub> Receptor Polymorphism in Association with Cerebral Infarction and its Regulation on Platelet Function
Current Neurovascular Research Risk Factors in Cardiovascular Disease in Systemic Lupus Erythematosus
Current Cardiology Reviews Review of the Biological Activity of Maslinic Acid
Current Drug Targets Role of Hydrogen Sulfide in Systemic and Pulmonary Hypertension: Cellular Mechanisms and Therapeutic Implications
Cardiovascular & Hematological Agents in Medicinal Chemistry Pharmacological Characteristics and Clinical Applications of K201
Current Clinical Pharmacology Impact of Sex on Office White Coat effect Tail: A Review
Current Pharmaceutical Design Chagas Heart Disease Pathogenesis: One Mechanism or Many?
Current Molecular Medicine Translational Applications of Tissue Engineering in Cardiovascular Medicine
Current Pharmaceutical Design