Abstract
In this review we discuss the current knowledge on Biomarkers of Aging (BoAs) in the context of human diseases and their value as predictive or prognostic markers. The vast majority of studies using BoAs in a clinical context have been undertaken by determining telomere length in peripheral blood mononuclear cells (PBMCs), whereas the expression of cell cycle inhibitors and an increase in advanced glycation end products (AGEs) have rarely been used. Here we summarize the impact of BoAs on non-oncological, hematological, cardiovascular, metabolic, renal and neurological diseases, as well as on overall survival. The specific methodologies utilized are described and evaluated for their high-throughput potential.
Keywords: Biomarkers, BoAs, Predictive, Prognostic, Telomere, Aging, Outcome
Current Medicinal Chemistry
Title: Biomarkers of Aging with Prognostic and Predictive Value in Non-Oncological Diseases
Volume: 16 Issue: 27
Author(s): Christian Koppelstaetter, Georg Kern and Gert Mayer
Affiliation:
Keywords: Biomarkers, BoAs, Predictive, Prognostic, Telomere, Aging, Outcome
Abstract: In this review we discuss the current knowledge on Biomarkers of Aging (BoAs) in the context of human diseases and their value as predictive or prognostic markers. The vast majority of studies using BoAs in a clinical context have been undertaken by determining telomere length in peripheral blood mononuclear cells (PBMCs), whereas the expression of cell cycle inhibitors and an increase in advanced glycation end products (AGEs) have rarely been used. Here we summarize the impact of BoAs on non-oncological, hematological, cardiovascular, metabolic, renal and neurological diseases, as well as on overall survival. The specific methodologies utilized are described and evaluated for their high-throughput potential.
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Cite this article as:
Koppelstaetter Christian, Kern Georg and Mayer Gert, Biomarkers of Aging with Prognostic and Predictive Value in Non-Oncological Diseases, Current Medicinal Chemistry 2009; 16 (27) . https://dx.doi.org/10.2174/092986709789057644
DOI https://dx.doi.org/10.2174/092986709789057644 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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