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Current Molecular Medicine

Editor-in-Chief

ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

Posttranscriptional Regulation of p53 and its Targets by RNABinding Proteins

Author(s): Jin Zhang and Xinbin Chen

Volume 8, Issue 8, 2008

Page: [845 - 849] Pages: 5

DOI: 10.2174/156652408786733748

Price: $65

Abstract

p53 tumor suppressor plays a pivotal role in maintaining genomic integrity and preventing cancer development. The importance of p53 in tumor suppression is illustrated by the observation that about 50% human tumor cells have a dysfunctional p53 pathway. Although it has been well accepted that the activity of p53 is mainly controlled through post-translational modifications, recent studies have revealed that posttranscriptional regulations of p53 by various RNA-binding proteins also play a crucial role in modulating p53 activity and its downstream targets.

Keywords: p53, posttranscriptional regulation, RNA-binding proteins, translational regulation, mRNA decay

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