Abstract
Deoxyribonucleic acid (DNA) biosensor based on a carbon nanotube (CNT) modified electrode was developed as an anticancer drug screening device for rapid electrochemical detection of cyclophosphamide. Screen-printing technology was employed to fabricate electrodes for biosensor construction. The interaction of cyclophosphamide with double stranded (ds) calf thymus DNA was detected with the developed CNT-based biosensor and compared with the carbon paste based biosensor by using differential pulse voltammetry. The preliminary results indicate that the developed CNT-based DNA biosensor exhibited a faster response and a higher detection reproducibility compared to the carbon paste based biosensor.
Keywords: Anti-cancer drug, electrochemical DNA biosensors, cyclophosphamide, carbon nanotubes, anticancer drug interactions
Current Nanoscience
Title: Carbon Nanotube Based DNA Biosensor for Rapid Detection of Anti-Cancer Drug of Cyclophosphamide
Volume: 5 Issue: 3
Author(s): Sigen Wang, Ruili Wang, Paul J. Sellin and Sha Chang
Affiliation:
Keywords: Anti-cancer drug, electrochemical DNA biosensors, cyclophosphamide, carbon nanotubes, anticancer drug interactions
Abstract: Deoxyribonucleic acid (DNA) biosensor based on a carbon nanotube (CNT) modified electrode was developed as an anticancer drug screening device for rapid electrochemical detection of cyclophosphamide. Screen-printing technology was employed to fabricate electrodes for biosensor construction. The interaction of cyclophosphamide with double stranded (ds) calf thymus DNA was detected with the developed CNT-based biosensor and compared with the carbon paste based biosensor by using differential pulse voltammetry. The preliminary results indicate that the developed CNT-based DNA biosensor exhibited a faster response and a higher detection reproducibility compared to the carbon paste based biosensor.
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Cite this article as:
Wang Sigen, Wang Ruili, Sellin J. Paul and Chang Sha, Carbon Nanotube Based DNA Biosensor for Rapid Detection of Anti-Cancer Drug of Cyclophosphamide, Current Nanoscience 2009; 5 (3) . https://dx.doi.org/10.2174/157341309788921372
DOI https://dx.doi.org/10.2174/157341309788921372 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
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