Abstract
Diabetes, characterized by chronic hyperglycemia, has reached serious epidemic proportions. It is also not infrequent to find increased incidence of liver injury in diabetics and hyperglycemia plays an important role in promoting liver injury through several mechanisms. The following review identifies the pathways through which hyperglycemia causes changes in liver of various animal models and liver cell culture models, and elucidates the mechanisms and consequences of hyperglycemia induced liver injury in humans. Some of the pathways which are hyperglycemia driven include increased oxidative and nitrosative stress, activation of stress signaling pathways and increased cytokine levels, impairment of protective mechanisms such as the expression of molecular chaperones and proteosome activity, and dysregulation of glucose and lipid metabolism. Thus, hyperglycemia induced changes in the livers cellular environment in in vitro and in vivo models have been documented extensively in the literature.
Keywords: High glucose, Liver, Animal models, Hepatocytes, HepG2, Steatohepatitis
Current Diabetes Reviews
Title: Hyperglycemia Induced Changes in Liver: In vivo and In vitro Studies
Volume: 5 Issue: 2
Author(s): Aparajita Dey and Karthikeyan Chandrasekaran
Affiliation:
Keywords: High glucose, Liver, Animal models, Hepatocytes, HepG2, Steatohepatitis
Abstract: Diabetes, characterized by chronic hyperglycemia, has reached serious epidemic proportions. It is also not infrequent to find increased incidence of liver injury in diabetics and hyperglycemia plays an important role in promoting liver injury through several mechanisms. The following review identifies the pathways through which hyperglycemia causes changes in liver of various animal models and liver cell culture models, and elucidates the mechanisms and consequences of hyperglycemia induced liver injury in humans. Some of the pathways which are hyperglycemia driven include increased oxidative and nitrosative stress, activation of stress signaling pathways and increased cytokine levels, impairment of protective mechanisms such as the expression of molecular chaperones and proteosome activity, and dysregulation of glucose and lipid metabolism. Thus, hyperglycemia induced changes in the livers cellular environment in in vitro and in vivo models have been documented extensively in the literature.
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Cite this article as:
Dey Aparajita and Chandrasekaran Karthikeyan, Hyperglycemia Induced Changes in Liver: In vivo and In vitro Studies, Current Diabetes Reviews 2009; 5 (2) . https://dx.doi.org/10.2174/157339909788166864
DOI https://dx.doi.org/10.2174/157339909788166864 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
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