Abstract
There is a brief summary of the early background literature about purinergic signalling and its involvement in pain, of ATP storage, release and ectoenzymatic breakdown and of the current classification of receptor subtypes for purines and pyrimidines. The review then focuses on purinergic mechanosensory transduction involved in visceral, cutaneous and musculoskeletal nociception and on the roles played by P2X3, P2Y2/3, P2X4, P2X7 and P2Y12 receptors in neuropathic and inflammatory pain. Current developments of compounds for the therapeutic treatment of both visceral and neuropathic pain are discussed.
Keywords: ATP, bladder, gut, inflammatory, joints, mechanosensory transduction, neuropathic
Current Pharmaceutical Design
Title: Purinergic Receptors and Pain
Volume: 15 Issue: 15
Author(s): Geoffrey Burnstock
Affiliation:
Keywords: ATP, bladder, gut, inflammatory, joints, mechanosensory transduction, neuropathic
Abstract: There is a brief summary of the early background literature about purinergic signalling and its involvement in pain, of ATP storage, release and ectoenzymatic breakdown and of the current classification of receptor subtypes for purines and pyrimidines. The review then focuses on purinergic mechanosensory transduction involved in visceral, cutaneous and musculoskeletal nociception and on the roles played by P2X3, P2Y2/3, P2X4, P2X7 and P2Y12 receptors in neuropathic and inflammatory pain. Current developments of compounds for the therapeutic treatment of both visceral and neuropathic pain are discussed.
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Cite this article as:
Burnstock Geoffrey, Purinergic Receptors and Pain, Current Pharmaceutical Design 2009; 15 (15) . https://dx.doi.org/10.2174/138161209788186335
DOI https://dx.doi.org/10.2174/138161209788186335 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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