Abstract
Non-melanoma skin cancer (NMSC) is the most frequent malignancy in the United States, with over one million new cases reported annually. Approximately 80% of NMSC are basal cell carcinomas (BCC), while the remaining 20% of NMSC are squamous cell carcinomas (SCC). BCC and SCC commonly arise in regions of the skin subjected to chronic sun exposure implicating ultraviolet radiation (UV)-induced cellular damage as the primary causative agent. While surgical excision is an effective treatment of NMSC, strategies aimed at NMSC prevention have not been exploited clinically. The application of sunscreens has been the primary means of prevention by physically blocking the absorption of UV radiation. However, sunscreens have had limited success in decreasing NMSC incidence overall, necessitating more targeted strategies against UV damage. In this review we will discuss the relevance of recently identified UVinduced cellular changes, including induction of reactive oxygen species, immune modulation, and damage to mitochondrial DNA to serve as potential targets for the chemoprevention of NMSC. Finally, we will discuss the potential of genes required for the maintenance of epithelial stem cells in the skin as therapeutic targets for cutaneous cancer.
Keywords: Non melanoma skin cancer, ultraviolet radiation, reactive oxygen species, inflammation, stem cell, keratinocyte
Current Cancer Therapy Reviews
Title: Squamous Cell Carcinoma of the Skin: Current Strategies for Treatment and Prevention
Volume: 5 Issue: 1
Author(s): Michael A. Bachelor and David M. Owens
Affiliation:
Keywords: Non melanoma skin cancer, ultraviolet radiation, reactive oxygen species, inflammation, stem cell, keratinocyte
Abstract: Non-melanoma skin cancer (NMSC) is the most frequent malignancy in the United States, with over one million new cases reported annually. Approximately 80% of NMSC are basal cell carcinomas (BCC), while the remaining 20% of NMSC are squamous cell carcinomas (SCC). BCC and SCC commonly arise in regions of the skin subjected to chronic sun exposure implicating ultraviolet radiation (UV)-induced cellular damage as the primary causative agent. While surgical excision is an effective treatment of NMSC, strategies aimed at NMSC prevention have not been exploited clinically. The application of sunscreens has been the primary means of prevention by physically blocking the absorption of UV radiation. However, sunscreens have had limited success in decreasing NMSC incidence overall, necessitating more targeted strategies against UV damage. In this review we will discuss the relevance of recently identified UVinduced cellular changes, including induction of reactive oxygen species, immune modulation, and damage to mitochondrial DNA to serve as potential targets for the chemoprevention of NMSC. Finally, we will discuss the potential of genes required for the maintenance of epithelial stem cells in the skin as therapeutic targets for cutaneous cancer.
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Bachelor A. Michael and Owens M. David, Squamous Cell Carcinoma of the Skin: Current Strategies for Treatment and Prevention, Current Cancer Therapy Reviews 2009; 5 (1) . https://dx.doi.org/10.2174/157339409787314090
DOI https://dx.doi.org/10.2174/157339409787314090 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
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