Abstract
Mucoadhesive patch releasing the drug in the oral cavity at predetermined rate may present distinct advantages over traditional dosage forms such as tablets, gels and solutions. The present study was concerned with the preparation and evaluation of mucoadhesive buccal patches for the controlled systemic delivery of Salbutamol sulphate to avoid first pass hepatic metabolism. The developed patches were evaluated for the physicochemical, mechanical and drug release characteristics. The patches showed desired mechanical and physicochemical properties to withstand environment of oral cavity. The in-vitro release study showed that patches could deliver drug to the oral mucosa for a period of 7 h. the patches exhibited adequate stability when tested under accelerated conditions.
Keywords: Mucoadhesion, Buccal patch, Salbutamol sulphate, buccal delivery, release study
Current Drug Delivery
Title: Development and Characterization of Mucoadhesive Buccal Patches of Salbutamol Sulphate
Volume: 6 Issue: 1
Author(s): Rajesh Singh Patel and S. S. Poddar
Affiliation:
Keywords: Mucoadhesion, Buccal patch, Salbutamol sulphate, buccal delivery, release study
Abstract: Mucoadhesive patch releasing the drug in the oral cavity at predetermined rate may present distinct advantages over traditional dosage forms such as tablets, gels and solutions. The present study was concerned with the preparation and evaluation of mucoadhesive buccal patches for the controlled systemic delivery of Salbutamol sulphate to avoid first pass hepatic metabolism. The developed patches were evaluated for the physicochemical, mechanical and drug release characteristics. The patches showed desired mechanical and physicochemical properties to withstand environment of oral cavity. The in-vitro release study showed that patches could deliver drug to the oral mucosa for a period of 7 h. the patches exhibited adequate stability when tested under accelerated conditions.
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Cite this article as:
Patel Singh Rajesh and Poddar S. S., Development and Characterization of Mucoadhesive Buccal Patches of Salbutamol Sulphate, Current Drug Delivery 2009; 6 (1) . https://dx.doi.org/10.2174/156720109787048177
DOI https://dx.doi.org/10.2174/156720109787048177 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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