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Current Drug Delivery

Editor-in-Chief

ISSN (Print): 1567-2018
ISSN (Online): 1875-5704

Development and Characterization of Mucoadhesive Buccal Patches of Salbutamol Sulphate

Author(s): Rajesh Singh Patel and S. S. Poddar

Volume 6, Issue 1, 2009

Page: [140 - 144] Pages: 5

DOI: 10.2174/156720109787048177

Price: $65

Abstract

Mucoadhesive patch releasing the drug in the oral cavity at predetermined rate may present distinct advantages over traditional dosage forms such as tablets, gels and solutions. The present study was concerned with the preparation and evaluation of mucoadhesive buccal patches for the controlled systemic delivery of Salbutamol sulphate to avoid first pass hepatic metabolism. The developed patches were evaluated for the physicochemical, mechanical and drug release characteristics. The patches showed desired mechanical and physicochemical properties to withstand environment of oral cavity. The in-vitro release study showed that patches could deliver drug to the oral mucosa for a period of 7 h. the patches exhibited adequate stability when tested under accelerated conditions.

Keywords: Mucoadhesion, Buccal patch, Salbutamol sulphate, buccal delivery, release study


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