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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

The Chiptip: A Novel Tool for Automated Patch Clamp

Author(s): Andjelko Golubovic, Martina Knirsch, Uwe Czubayko, Alexander Hummer, Albrecht Lepple-Wienhues and Dirck Lassen

Volume 12, Issue 1, 2009

Page: [73 - 77] Pages: 5

DOI: 10.2174/138620709787047984

Price: $65

Abstract

To facilitate automated patch clamp measurements of ion channels in cells, the development of an all-glass Chiptip pipette is reported that may be combined with the previously described Flip-the-Tip technology. A single measurement requires less than 50 cells, and the addition of drugs for screening can be limited to very low volumes down to 1 μL. This apparatus is suitable for the study small cells, subcellular organelles and bacteria.

Keywords: ligand gated channel, voltage gated channel, membrane protein, glass micropipettes, automated patch clamp, Ion channel


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