Abstract
Advances in molecular biology and biochemistry have dramatically increased our understanding of disease. The molecular mechanisms are the pathogenic basis of disease is changing modern medicine. New drugs often inhibit specific key pathways. In nuclear medicine, molecular imaging agents have been used for years, but most contrast agents for MRI or CT today are unspecific. The diagnosis is based on alterations in morphology and basic physiology, all of which are late manifestations of the original molecular changes. There are only few more specific contrast agents available. Microbubbles are the one, of size of blood cells are used as contrast agents for ultrasound imaging and are particularly valuable for targeting selected tissues and for providing useful information about the efficacy of chemotherapy. The exploitation of microbubble agents can be achieved when there is a full understanding of the bubble/ultrasound interaction for microbubbles freely suspended in blood or attached to blood vessel walls. Microbubbles are promising tool for targeting chemotherapeutics, polypeptides and genetic material to its target in body.
Keywords: Microbubble, ultrasound contrast agent, molecular imaging
Current Pharmaceutical Biotechnology
Title: Microbubble: A Potential Ultrasound Tool in Molecular Imaging
Volume: 9 Issue: 5
Author(s): Rajesh M. Patel
Affiliation:
Keywords: Microbubble, ultrasound contrast agent, molecular imaging
Abstract: Advances in molecular biology and biochemistry have dramatically increased our understanding of disease. The molecular mechanisms are the pathogenic basis of disease is changing modern medicine. New drugs often inhibit specific key pathways. In nuclear medicine, molecular imaging agents have been used for years, but most contrast agents for MRI or CT today are unspecific. The diagnosis is based on alterations in morphology and basic physiology, all of which are late manifestations of the original molecular changes. There are only few more specific contrast agents available. Microbubbles are the one, of size of blood cells are used as contrast agents for ultrasound imaging and are particularly valuable for targeting selected tissues and for providing useful information about the efficacy of chemotherapy. The exploitation of microbubble agents can be achieved when there is a full understanding of the bubble/ultrasound interaction for microbubbles freely suspended in blood or attached to blood vessel walls. Microbubbles are promising tool for targeting chemotherapeutics, polypeptides and genetic material to its target in body.
Export Options
About this article
Cite this article as:
Patel M. Rajesh, Microbubble: A Potential Ultrasound Tool in Molecular Imaging, Current Pharmaceutical Biotechnology 2008; 9 (5) . https://dx.doi.org/10.2174/138920108785915175
DOI https://dx.doi.org/10.2174/138920108785915175 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
Call for Papers in Thematic Issues
Artificial Intelligence in Bioinformatics
Bioinformatics is an interdisciplinary field that analyzes and explores biological data. This field combines biology and information system. Artificial Intelligence (AI) has attracted great attention as it tries to replicate human intelligence. It has become common technology for analyzing and solving complex data and problems and encompasses sub-fields of machine ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Inflammatory Mechanisms of Adverse Reactions to Drug-Eluting Stents
Current Vascular Pharmacology NPY and NPY Receptors in Vascular Remodeling
Current Topics in Medicinal Chemistry Metabolic Syndrome and Aging: Calcium Signaling as Common Regulator
Current Diabetes Reviews Acute Coronary Syndromes: A Role of Immune System
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Anorexia Nervosa and the Use of Total Parenteral Nutrition Refeeding
Current Nutrition & Food Science Anesthetic Cardioprotection in Clinical Practice From Proof-of-Concept to Clinical Applications
Current Pharmaceutical Design Anabolic-androgenic Steroid use and Psychopathology in Athletes. A Systematic Review
Current Neuropharmacology Treatment of Luteal Phase Defects in Assisted Reproduction
Current Drug Targets Scaffold Vascularization: A Challenge for Three-Dimensional Tissue Engineering
Current Medicinal Chemistry Current Therapeutic Strategies and Future Perspectives for the Prevention of Arterial Thromboembolism: Focus on Atrial Fibrillation
Current Pharmaceutical Design Intracellular Protozoan Parasites of Humans: The Role of Molecular Chaperones in Development and Pathogenesis
Protein & Peptide Letters VEGF Mediates ApoE4-Induced Neovascularization and Synaptic Pathology in the Choroid and Retina
Current Alzheimer Research Endothelial Remodelling and Intracellular Calcium Machinery
Current Molecular Medicine Endoplasmic Stress Inhibitors for Homocysteine Induced Cardiovascular Disease
Current Pharmaceutical Design Understanding the Mechanism and Prevention of Arterial Occlusive Thrombus Formation by Anti-Platelet Agents
Current Medicinal Chemistry - Cardiovascular & Hematological Agents Nicotine Addiction and Coronary Artery Disease: Impact of Cessation Interventions
Current Pharmaceutical Design Critical Determinants of Cardiovascular Risk in Rheumatoid Arthritis
Current Pharmaceutical Design Anti-Platelet Therapy and Aspirin Resistance – Clinically and Chemically Relevant?
Current Medicinal Chemistry Pediatrics for Disability: A Comprehensive Approach to Children with Syndromic Psychomotor Delay
Current Pediatric Reviews The Role of An Experimental Model of Atherosclerosis: apoE-knockout Mice in Developing New Drugs against Atherogenesis
Current Pharmaceutical Biotechnology