Generic placeholder image

Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Expanding the Chemical Space in Practice: Diversity-Oriented Synthesis

Author(s): Marine Peuchmaur and Yung-Sing Wong

Volume 11, Issue 8, 2008

Page: [587 - 601] Pages: 15

DOI: 10.2174/138620708785739916

Price: $65

Abstract

Diversity-Oriented Synthesis (DOS) aims to broaden the frontier of accessible collections of complex and diverse small molecules. This review endeavours to dissect the DOS concept through three elements of diversity: building block, stereochemistry, and skeleton. Recent examples in the literature that emphasize the efficient combinations of these elements to generate diversity are reported.

Keywords: Diversity-Oriented Synthesis, small molecules, complexity, diversity, multicomponent reactions, stereodivergent reactions, skeletal divergent reactions, chemical space


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy