Current Molecular Pharmacology

Oral Administration of the Food-Derived Hydrophilic Antioxidant Ergothioneine Enhances Object Recognition Memory in Mice

Volume: 14   Issue: 2
Pp: 220-233
Noritaka Nakamichi, Shunsuke Nakao, Misa Nishiyama, Yuka Takeda, Takahiro Ishimoto, Yusuke Masuo, Satoshi Matsumoto, Makoto Suzuki and Yukio Kato*
DOI: 10.2174/1874467213666200212102710

Possibility that the Onset of Autism Spectrum Disorder is Induced by Failure of the Glutamine-Glutamate Cycle

Volume: 14   Issue: 2
Pp: 170-174
Koichi Kawada*, Nobuyuki Kuramoto and Seisuke Mimori
DOI: 10.2174/1874467213666200319125109

Polyphenols can Potentially Prevent Atherosclerosis and Cardiovascular Disease by Modulating Macrophage Cholesterol Metabolism

Volume: 14   Issue: 2
Pp: 175-190
Fumiaki Ito*
DOI: 10.2174/1874467213666200320153410

TRPC3-Based Protein Signaling Complex as a Therapeutic Target of Myocardial Atrophy

Volume: 14   Issue: 2
Pp: 123-131
Kazuhiro Nishiyama, Tomohiro Tanaka, Akiyuki Nishimura and Motohiro Nishida*
DOI: 10.2174/1874467213666200407090121

Molecular Mechanisms Involved in the Progression and Protection of Osteoarthritis

Volume: 14   Issue: 2
Pp: 165-169
Yoshifumi Takahata*, Tomohiko Murakami, Kenji Hata and Riko Nishimura
DOI: 10.2174/1874467213666200417122933

Acetate Suppresses Lipopolysaccharide-stimulated Nitric Oxide Production in Primary Rat Microglia but not in BV-2 Microglia Cells

Volume: 14   Issue: 2
Pp: 253-260
Mitsuaki Moriyama*, Yasunori Nishimura, Ryosuke Kurebayashi, Tomoki Minamihata, Kenji Kawabe, Katsura Takano and Yoichi Nakamura
DOI: 10.2174/1874467213666200420101048

Melatonin Receptor as a Drug Target for Neuroprotection

Volume: 14   Issue: 2
Pp: 150-164
Pawaris Wongprayoon and Piyarat Govitrapong*
DOI: 10.2174/1874467213666200421160835

Elimination of the Causes of Poor Sleep Underlying Delirium is a Basic Strategy to Prevent Delirium

Volume: 14   Issue: 2
Pp: 132-137
Riyo Enomoto and Eibai Lee-Hiraiwa*
DOI: 10.2174/1874467213666200424150709

Interleukin-19 as an Immunoregulatory Cytokine

Volume: 14   Issue: 2
Pp: 191-199
Yasuyuki Fujimoto, Nobuyuki Kuramoto, Masanori Yoneyama and Yasu-Taka Azuma*
DOI: 10.2174/1874467213666200424151528

Protective Potential of Ginkgo biloba Against an ADHD-like Condition

Volume: 14   Issue: 2
Pp: 200-209
Garima Sharma, Naveen Sharma, Bao Trong Nguyen, Ji Hoon Jeong, Seung-Yeol Nah, Yukio Yoneda, Eun-Joo Shin and Hyoung-Chun Kim*
DOI: 10.2174/1874467213666200424152454

Actions of Alcohol in Brain: Genetics, Metabolomics, GABA Receptors, Proteomics and Glutamate Transporter GLAST/EAAT1

Volume: 14   Issue: 2
Pp: 138-149
Mohammed Abul Kashem, Omar Šerý, David V. Pow, Benjamin D. Rowlands, Caroline D. Rae and Vladimir J. Balcar*
DOI: 10.2174/1874467213666200424155244

Chronic Royal Jelly Administration Induced Antidepressant-Like Effects Through Increased Sirtuin1 and Oxidative Phosphorylation Protein Expression in the Amygdala of Mice

Volume: 14   Issue: 2
Pp: 115-122
Thanh Trung Nguyen, Yuki Kambe* and Atsuro Miyata
DOI: 10.2174/1874467213666200424160153

Lactoferrin Suppresses Decreased Locomotor Activities by Improving Dopamine and Serotonin Release in the Amygdala of Ovariectomized Rats open access plus

Volume: 14   Issue: 2
Pp: 245-252
Nobuo Izumo*, Ishibashi Yukiko, Nobuharu Kagaya, Megumi Furukawa, Rina Iwasaki, Akihide Sumino, Kohsuke Hayamizu, Makoto Nakano, Tatsuo Hoshino, Haruna Kurono, Yasuo Watanabe and Takayuki Manabe*
DOI: 10.2174/1570163817666200430002937

Eucommia Leaf Extract Induces BDNF Production in Rat Hypothalamus and Enhances Lipid Metabolism and Aerobic Glycolysis in Rat Liver

Volume: 14   Issue: 2
Pp: 234-244
Hirotaka Oikawa, Shouhei Miyazaki, Rina Kurata, Mutsumi Hattori, Noriko Hayashi, Nami Kawaguchi, Tetsuya Hirata, Taro Ueda and Takahiko Fujikawa*
DOI: 10.2174/1874467213666200505094631

Apelin/Apelin Receptor System: Molecular Characteristics, Physiological Roles, and Prospects as a Target for Disease Prevention and Pharmacotherapy

Volume: 14   Issue: 2
Pp: 210-219
Toshihiko Kinjo, Hiroshi Higashi, Kyosuke Uno and Nobuyuki Kuramoto*
DOI: 10.2174/1874467213666200602133032

Prophylactic Pharmacology for Preemptive Medicine promotion: free to download

Volume: 14   Issue: 2
Pp: 113-114
Yukio Yoneda
DOI: 10.2174/187446721402201231223559

CircRNA 001418 Promoted Cell Growth and Metastasis of Bladder Carcinoma via EphA2 by miR-1297

Volume: 14   Issue: 1
Pp: 68-78
Guorui Peng, Hongxue Meng, Hongxin Pan and Wentao Wang*
DOI: 10.2174/1874467213666200505093815

Anticonvulsant, Anxiolytic and Antidepressant Properties of the β-caryophyllene in Swiss Mice: Involvement of Benzodiazepine-GABAAergic, Serotonergic and Nitrergic Systems

Volume: 14   Issue: 1
Pp: 36-51
George L. da Silva Oliveira*, José C. Correia L. da Silva, Ana P. dos Santos C. L da Silva, Chistiane M. Feitosa and Fernanda R. de Castro Almeida
DOI: 10.2174/1874467213666200510004622

Effects of Galbanic Acid on Proliferation, Migration, and Apoptosis of Glioblastoma Cells Through the PI3K/Akt/MTOR Signaling Pathway

Volume: 14   Issue: 1
Pp: 79-87
Seyed H. Shahcheraghi, Marzieh Lotfi, Mohammad Soukhtanloo, Majid Ghayour Mobarhan, Hossein Z. Jaliani, Hamid R. Sadeghnia* and Ahmad Ghorbani*
DOI: 10.2174/1874467213666200512075507

Azacitidine, as a DNMT Inhibitor Decreases hTERT Gene Expression and Telomerase Activity More Effective Compared with HDAC Inhibitor in Human Head and Neck Squamous Cell Carcinoma Cell Lines

Volume: 14   Issue: 1
Pp: 60-67
Sepideh Atri, Nikoo Nasoohi and Mahshid Hodjat*
DOI: 10.2174/1874467213666200512080122

Alcoholic Neuropathy: Involvement of Multifaceted Signalling Mechanisms

Volume: 14   Issue: 1
Pp: 2-10
Tapan Behl*, Harlokesh N. Yadav and Pyare L. Sharma
DOI: 10.2174/1874467213666200512114943

The Impact of Royal Jelly against Hepatic Ischemia/Reperfusion-Induced Hepatocyte Damage in Rats: The Role of Cytoglobin, Nrf-2/HO-1/COX-4, and P₃₈-MAPK/NF-κB-p65/TNF-α Signaling Pathways

Volume: 14   Issue: 1
Pp: 88-100
Fares E.M. Ali*, Heba M. Saad Eldien, Nashwa A.M. Mostafa, Abdulrahman H. Almaeen, Mohamed R.A. Marzouk, Khalid M. Eid, Ahmed H.E. Ghoziz, Abdelaziz F. Ebrahiem, Mohamed G. Hagag and Osama M. Ghogar
DOI: 10.2174/1874467213666200514223829

Determining the Relative Gene Expression Level of Hypoxia Related Genes in Different Cancer Cell Lines

Volume: 14   Issue: 1
Pp: 52-59
Laila Baqlouq*, Malek Zihlif*, Hana Hammad and Tuqa M. Abu Thaib
DOI: 10.2174/1874467213666200521081653

Nuezhenide Exerts Anti-Inflammatory Activity through the NF-κB Pathway open access plus

Volume: 14   Issue: 1
Pp: 101-111
Qin-Qin Wang, Shan Han, Xin-Xing Li, Renyikun Yuan, Youqiong Zhuo, Xinxin Chen, Chenwei Zhang, Yangling Chen, Hongwei Gao*, Li-Chun Zhao* and Shilin Yang
DOI: 10.2174/1874467213666200611141337

Valproic acid, A Potential Inducer of Osteogenesis in Mouse Mesenchymal Stem Cells

Volume: 14   Issue: 1
Pp: 27-35
Narayanan Akshaya, Prakash Prasith, Balakrishnan Abinaya, Badrinath Ashwin, S.V. Chandran and Nagarajan Selvamurugan*
DOI: 10.2174/1874467213666200713102410

A Review of the Potential Receptors of Migraine with a Special Emphasis on CGRP to Develop an Ideal Antimigraine Drug

Volume: 14   Issue: 1
Pp: 11-26
Krishna P. Naduchamy and Varadarajan Parthasarathy*
DOI: 10.2174/1874467213999200824124532

Preface promotion: free to download

Volume: 14   Issue: 1
Pp: 1-1
Michael Kahn
DOI: 10.2174/187446721401201231214147

MicroRNA Regulation of TRAIL in Renal Carcinoma: Tiny Juggernauts at Work

Volume: 14   Issue:
Pp: 1-7
Zeeshan Javed, Khushbukhat Khan, Haleema Sadia, Shahid Raza, Javad Sharifi-Rad* and William C. Cho*
DOI: 10.2174/1874467213999201124124649

Effects of Mycotoxins on Child Development

Volume: 14   Issue:
Pp: 1-13
Gül Kadan and Neriman Aral*
DOI: 10.2174/1874467213999201214225531

Quercetin in Attenuation of Ischemic/Reperfusion Injury: A Review

Volume: 14   Issue:
Pp: 1-22
Milad Ashrafizadeh, Saeed Samarghandian, Kiavash Hushmandi, Amirhossein Zabolian, Md Shahinozzaman, Hossein Saleki, Hossein Esmaeili, Mehdi Raei, Maliheh Entezari, Ali Zarrabi* and Masoud Najafi*
DOI: 10.2174/1874467213666201217122544

Polyphenols as Potential Therapeutics for Pain and Inflammation in Spinal Cord Injury

Volume: 14   Issue:
Pp: 1-17
Ashif Iqubal, Musheer Ahmed, Mohammad Kashif Iqubal, Faheem Hyder Pottoo and Syed Ehtaishamul Haque*
DOI: 10.2174/1874467213666201223111743

MicroRNA Regulation of Androgen Receptor in Castration-Resistant Prostate Cancer: Premises, Promises, and Potentials

Volume: 14   Issue:
Pp: 1-11
Safieh Ebrahimi, Seyed Isaac Hashemy, Amirhossein Sahebkar* and Seyed Hamid AghaeeBakhtiari
DOI: 10.2174/1874467213666201223121850

The mechanistic role of thymoquinone in Parkinson's disease: focus on neuroprotection in pre-clinical studies

Volume: 14   Issue:
Pp: 1-12
Mohammad Najim Uddin, Mohammad Injamul Hoq, Israt Jahan, Shafayet Ahmed Siddiqui, Chayan Dhar Clinton, Mohammed Ibrahim, Mohammad Safiqul Islam and Md. Jakaria*
DOI: 10.2174/1874467214666210105140944

Chlorpyrifos with age-dependent effects in cardiac tissue of male rats

Volume: 14   Issue:
Pp: 1-1
Behzad Mesbahzadeh, Hossein Salarjavan, Saeed Samarghandian* and Tahereh Farkhondeh*
DOI: 10.2174/1874467214666210111105321

Bovine lactoferrin as a modulator of neuroendocrine components of stress

Volume: 14   Issue:
Pp: 1-11
Fabiola Guzmán-Mejía, Alan Vega-Bautista, Daniel Efrain Molotla-Torres, José Félix Aguirre-Garrido and Maria Elisa Drago-Serrano*
DOI: 10.2174/1874467214999210111211947

A Realistic Approach for Anti-inflammatory, Antinociceptive and Antimutagenic Activities, and Risk Assessment of the Aqueous Extract of Platanus orientalis L. Leaves

Volume: 14   Issue:
Pp: 1-7
Erdem Yesilada*, Esra Küpeli Akkol, Ahmet Aydin and Muhammed Hamitoğlu
DOI: 10.2174/1874467214999210111220358

Quinoa (Chenopodium quinoa Willd.): exploring a superfood from Andean indigenous cultures with potential to reduce cardiovascular disease (CVD) risk markers

Volume: 14   Issue:
Pp: 1-12
Jaime López-Cervantes, Dalia Sánchez-Machado*, David Servín de la Mora-López and Ana Sanches-Silva
DOI: 10.2174/1874467214999210111222233

Salvia Miltiorrhiza in Anti-diabetic Angiopathy

Volume: 14   Issue:
Pp: 1-15
Zequn Yin, Xuerui Wang, Xiaoxiao Yang, Yuanli Chen, Yajun Duan* and Jihong Han
DOI: 10.2174/1874467214999210111222918

Recent Advancements in lung cancer treatment using receptor targeting

Volume: 14   Issue:
Pp: 1-1
Harjit Singh, Bharat Khurana and Sukhbir Kaur*
DOI: 10.2174/1874467214666210112105531

Exploring the Mitochondrial Apoptotic Cell Death Landscape and Associated Components Serving as Molecular targets, primarily for synthetic and natural drugs targeting oncology therapeutics

Volume: 14   Issue:
Pp: 1-1
Ishnoor Kaur, Tapan Behl*, Monika Sachdeva, Simona Bungau and Thangavel Venkatachalam
DOI: 10.2174/1874467214666210120145537

Protective Effects of Antrodia cinnamomea and Its Constituent Compound Dehydroeburicoic Acid 32 against Alcoholic Fatty Liver Disease

Volume: 14   Issue:
Pp: 1-1
Lu Xu, An-Kang Peng, Yi-ni Cao, Xue Qiao, Shan-Shan Yue, Min Ye* and Rong Qi*
DOI: 10.2174/1874467214666210120152140

Natural Products as PI3K/ Akt Inhibitors: Implications in Preventing Hepatocellular Carcinoma.

Volume: 14   Issue:
Pp: 1-1
Arunaksharan Narayanankutty*
DOI: 10.2174/1874467214666210120152657

Novel strategy in breast cancer therapy: Revealing the bright side of ginsenosides

Volume: 14   Issue:
Pp: 1-1
Farid Hashemi, Ali Zarrabi, Amirhossein Zabolian, Hossein Saleki, Mahdi Vasheghani Farahani, Seyed Omid Sharifzadeh, Zahra Ghahremaniyeh, Atefe Kazemzade Bejandi, Kiavash Hushmandi, Milad Ashrafizadeh* and Haroon Khan*
DOI: 10.2174/1874467214666210120153348

Hypoxia-inducible factor (HIF): fuel for cancer progression

Volume: 14   Issue:
Pp: 1-1
Saurabh Satija*, Harpreet Kaur*, Murtaza M. Tambuwala, Prabal Sharma, Manish Vyas, Navneet Khurana, Neha Sharma, Hamid A. Bakshi, Nitin B. Charbe, Flavia C Zacconi, Alaa A. Aljabali, Srinivas Nammi, Harish Dureja, Thakur Gurjeet Singh, Gaurav Gupta, Daljeet S. Dhanjal, Kamal Dua, Dinesh Kumar Chellappan* and Meenu Mehta*
DOI: 10.2174/1874467214666210120154929

Nanostructured Lipid Carriers for Intranasal Administration of Olanzapine in the management of Schizophrenia

Volume: 14   Issue:
Pp: 1-9
Sarbjot Kaur, Ujjwal Nautiyal, Pooja A. Chawla and Viney Chawla*
DOI: 10.2174/1874467214666210120160016

Epigenetic regulation and promising therapies in colorectal cancer

Volume: 14   Issue:
Pp: 1-1
Chandra Kishore*
DOI: 10.2174/1874467214666210126105345

Dantrolene Potentiates the Antineoplastic Effect of Sorafenib in Hepatocellular Carcinoma via Targeting Ca+2/PI3K Signaling Pathway

Volume: 14   Issue:
Pp: 1-1
Sherin Zakaria, Abeer Ansary*, Nabil M. Abdel-Hamid and Mamdouh M. ElShishtawy *
DOI: 10.2174/1874467214666210126110627

Ginkgolic Acids Confer Potential Anticancer Effects by Targeting Pro-Inflammatory and Oncogenic Signaling Molecules

Volume: 14   Issue:
Pp: 1-1
Muthu K. Shanmugam*, Manoj Garg , Pooja Makhija, Alan Prem Kumar , Javad Sharifi-Rad , Wissam Zam and Anupam Bishyaee *
DOI: 10.2174/1874467214666210126112413

Inactivation of parathyroid hormone: perspectives of drug discovery to combating hyperparathyroidism

Volume: 14   Issue:
Pp: 1-1
Amit Kumar* and Jochen Balbach*
DOI: 10.2174/1874467214666210126112839

Beneficial effect of rice bran extract against rotenone-induced experimental Parkinson’s disease in rats

Volume: 14   Issue:
Pp: 1-1
Sachin Kumar and Puneet Kumar*
DOI: 10.2174/1874467214666210126113324

Curcumin Efficacy in a Serum/glucose Deprivation-induced Neuronal PC12 Injury Model

Volume: 14   Issue:
Pp: 1-1
Tahereh Farkhondeh, Milad Ashrafizadeh, Mohsen Azimi-Nezhad, Fariborz Samini, Micheal Aschenr and Saeed Samarghandian*
DOI: 10.2174/1874467214666210203211312

TRIM65 in White Matter Lesions, Innate Immunity and Tumor

Volume: 14   Issue:
Pp: 1-1
Bingxue Liu, Yunlian Tang*, Ping Yang, Chu Wu and Yue Huang
DOI: 10.2174/1874467214666210203211603

An Overview and Therapeutic Promise of Nutraceuticals against Sports-Related Brain Injury

Volume: 14   Issue:
Pp: 1-1
Ashif Iqubal, Pratichi Bansal, Mohammad Kashif Iqubal, Faheem Hyder Pottoo and Syed Ehtaishamul Haque*
DOI: 10.2174/1874467214666210203211914

Di'ao Xinxuekang: Therapeutic Potential in Cardiovascular Diseases

Volume: 14   Issue:
Pp: 1-1
Shengyu Zhang, Lingli Li, Mingying Deng, Yanan Wang, AiZong Shen and Lei Zhang*
DOI: 10.2174/1874467214666210203212341

Ticagrelor Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Rats by Inhibition of TGF-β1/Smad3 and PI3K/AKT/mTOR Pathways

Volume: 14   Issue:
Pp: 1-1
Hanaa Wanas*, Zeinab El Shereef, Laila Rashed and Basma Emad Aboulhoda
DOI: 10.2174/1874467214666210204212533

The Potential for Phospholipids in the Treatment of Airway Inflammation: An Unexplored Solution

Volume: 14   Issue:
Pp: 1-1
Varsha Komalla, Meenu Mehta, Fatima Achi, Kamal Dua and Mehra Haghi*
DOI: 10.2174/1874467214666210208114439

Minocycline and doxycycline: More Than Antibiotics.

Volume: 14   Issue:
Pp: 1-1
Sher Singh, Deepa Khanna* and Sanjeev Kalra
DOI: 10.2174/1874467214666210210122628

Statins Attenuate Fibrotic Manifestations of Cardiac Tissue Damage

Volume: 14   Issue:
Pp: 1-1
Armita Mahdavi Gorabi, Nasim Kiaie, Vanessa Bianconi, Matteo Pirro, Tannaz Jamialahmadi and Amirhossein Sahebkar*
DOI: 10.2174/1874467214666210210123206

Flavonoids as prospective aromatase inhibitors in breast cancer prevention/therapy

Volume: 14   Issue:
Pp: 1-1
Richa Seth, Soni Kushwaha, Suaib Luqman and Abha Meena*
DOI: 10.2174/1874467214666210210123709

Formulation, characterisation and In vitro cytotoxic effect of Lens culinarisMedikus seeds extract loaded chitosan microspheres

Volume: 14   Issue:
Pp: 1-1
Kripi Vohra, Meenu Mehta, Vandana Garg, Kamal Dua* and Harish Dureja*
DOI: 10.2174/1874467214666210210124739

Inhibitory Effects of Cathepsin K Inhibitor (ODN-MK-0822) on the Paracrine Pro-Osteoclast Factors of Breast Cancer Cells

Volume: 14   Issue:
Pp: 1-1
Yaongamphi Vashum, Amuthavalli Kottaiswamy, Giridharan Bupesh, Riya Prem Singh, Parkavi Kalaiselvan, Thiagarajan K and Shila Samuel*
DOI: 10.2174/1874467214666210211162118

Assessment of Antioxidant Effect of Beta-Glucan on the Whole Blood Oxidative DNA Damage with the Comet Assay in Colorectal Cancer

Volume: 14   Issue:
Pp: 1-1
Necla Benlier, Nilay Uçar, Eda Öğüt, Havva Yeşil Çinkir, Mustafa Yildirim, Pınar Günel Karadeniz, Esra Küpeli Akkol*, Haroon Khan and Eyüp Ilker Saygili*
DOI: 10.2174/1874467214666210219145445

Daclatasvir and Sofosbuvir Mitigate Hepatic Fibrosis Through Downregulation of TNF-α / NF-κB Signaling Pathway

Volume: 13   Issue: 4
Pp: 318-327
Sherin Zakaria * and Alaa E. El-Sisi
DOI: 10.2174/1874467213666200116114919

miR-18a-3p Encourages Apoptosis of Chondrocyte in Osteoarthritis via HOXA1 Pathway

Volume: 13   Issue: 4
Pp: 328-341
Baiyang Ding, Shujuan Xu, Xiumin Sun, Jianming Gao, Wenlei Nie and Hongguang Xu *
DOI: 10.2174/1874467213666200204143740

Mechanism Involved in Fortification by Berberine in CDDP-Induced Nephrotoxicity

Volume: 13   Issue: 4
Pp: 342-352
Vipin K. Verma, Salma Malik, Ekta Mutneja, Anil K. Sahu, Kumari Rupashi, Amit K. Dinda, Dharamvir S. Arya and Jagriti Bhatia*
DOI: 10.2174/1874467213666200220142202

Hepatic Stellate Cell: A Potential Target for Hepatocellular Carcinoma

Volume: 13   Issue: 4
Pp: 261-272
Mengna Wu, Huajie Miao, Rong Fu, Jie Zhang* and Wenjie Zheng *
DOI: 10.2174/1874467213666200224102820

Evaluation of the Effects of 1,25 Vitamin D3 on Regulatory T Cells and T Helper 17 Cells in Vitamin D-deficient Women with Unexplained Recurrent Pregnancy Loss

Volume: 13   Issue: 4
Pp: 306-317
Elham Abdollahi, Seyed Abdolrahim Rezaee, Nafiseh Saghafi, Maryam Rastin, Vicki Clifton, Amirhossein Sahebkar and Houshang Rafatpanah*
DOI: 10.2174/1874467213666200303130153

Recent Updates in the Alzheimer’s Disease Etiopathology and Possible Treatment Approaches: A Narrative Review of Current Clinical Trials

Volume: 13   Issue: 4
Pp: 273-294
Elahe Zarini-Gakiye, Javad Amini, Nima Sanadgol*, Gholamhassan Vaezi and Kazem Parivar
DOI: 10.2174/1874467213666200422090135

Bacterial Siderophores and Their Potential Applications: A Review

Volume: 13   Issue: 4
Pp: 295-305
Pranav Kumar Prabhakar*
DOI: 10.2174/1874467213666200518094445

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Volume: 13   Issue: 4
Pp: 353-353

DOI: 10.2174/187446721304201001092608

Evaluation of the Anti-Tumor Activity of Niclosamide Nanoliposomes Against Colon Carcinoma

Volume: 13   Issue: 3
Pp: 245-250
Mahdi Hatamipour, Mahmoud R. Jaafari, Amir A. Momtazi-Borojeni, Mahin Ramezani and Amirhossein Sahebkar*
DOI: 10.2174/1874467212666190821142721

Small Interfering RNAs and their Delivery Systems: A Novel Powerful Tool for the Potential Treatment of HIV Infections

Volume: 13   Issue: 3
Pp: 173-181
Azam Bolhassani* and Alireza Milani
DOI: 10.2174/1874467212666191023120954

The Molecular and Enzyme Kinetic Basis for Altered Activity of Three Cytochrome P450 2C19 Variants Found in the Chinese Population

Volume: 13   Issue: 3
Pp: 233-244
Amelia Nathania Dong, Nafees Ahemad, Yan Pan, Uma Devi Palanisamy, Beow Chin Yiap and Chin Eng Ong*
DOI: 10.2174/1874467212666191111110429

FAT10: Function and Relationship with Cancer

Volume: 13   Issue: 3
Pp: 182-191
Senfeng Xiang, Xuejing Shao, Ji Cao, Bo Yang, Qiaojun He* and Meidan Ying*
DOI: 10.2174/1874467212666191113130312

The Impact of Spironolactone on Markers of Myocardial Oxidative Status, Inflammation and Remodeling in Hyperthyroid Rats

Volume: 13   Issue: 3
Pp: 206-215
Fadia A Mayyas*, Ahmad I Aljohmani and Karem H Alzoubi
DOI: 10.2174/1874467212666191113150553

Radio-Susceptibility of Nasopharyngeal Carcinoma: Focus on Epstein- Barr Virus, MicroRNAs, Long Non-Coding RNAs and Circular RNAs

Volume: 13   Issue: 3
Pp: 192-205
Fanghong Lei, Tongda Lei, Yun Huang, Mingxiu Yang, Mingchu Liao* and Weiguo Huang*
DOI: 10.2174/1874467213666191227104646

Role of Lacosamide in Preventing Pentylenetetrazole Kindling-Induced Alterations in the Expression of the Gamma-2 Subunit of the GABAA Receptor in Rats

Volume: 13   Issue: 3
Pp: 251-260
Zsolt Gáll*, Krisztina Kelemen, István Mihály, Pál Salamon, Ildikó Miklóssy, Brigitta Zsigmond and Melinda Kolcsár
DOI: 10.2174/1874467213666200102095023

MiR-143 Inhibits Osteoclastogenesis by Targeting RANK and NF-κB and MAPK Signaling Pathways

Volume: 13   Issue: 3
Pp: 224-232
Xianfeng He, Limei Zhu*, Lin An and Jingwei Zhang
DOI: 10.2174/1874467213666200116113945

Characterization of a New Positive Allosteric Modulator of AMPA Receptors - PAM-43: Specific Binding of the Ligand and its Ability to Potentiate AMPAR Currents

Volume: 13   Issue: 3
Pp: 216-223
Tatiana V. Vyunova*, Lioudmila A. Andreeva, Konstantin V. Shevchenko, Vladimir V. Grigoriev, Vladimir A. Palyulin, Mstislav I. Lavrov, Ekaterina V. Bondarenko, Elena E. Kalashnikova and Nikolay F. Myasoedov
DOI: 10.2174/1874467213666200303140834

Discovering Therapeutic Protein Targets for Bladder Cancer Using Proteomic Data Analysis

Volume: 13   Issue: 2
Pp: 150-172
Samira Bahrami, Bahram Kazemi*, Hakimeh Zali, Peter C. Black, Abbas Basiri, Mojgan Bandehpour, Mehdi Hedayati and Amirhossein Sahebkar
DOI: 10.2174/1874467212666191016124935

AdipoRon: A Novel Insulin Sensitizer in Various Complications and the Underlying Mechanisms: A Review

Volume: 13   Issue: 2
Pp: 94-107
Ishfaq Ahmad Bhat, Shaheen Wasil Kabeer, Mohammad Irshad Reza, Reyaz Hassan Mir* and Muhammad Ovais Dar
DOI: 10.2174/1874467212666191022102800

The Protective Effect of Cilostazol in Genotoxicity Induced by Methotrexate in Human Cultured Lymphocytes

Volume: 13   Issue: 2
Pp: 137-143
Abeer M. Rababa’h*, Samah A. Hussein, Omar F. Khabour and Karem H. Alzoubi
DOI: 10.2174/1874467212666191023120118

Detailed Molecular Biochemistry for Novel Therapeutic Design Against Nipah and Hendra Virus: A Systematic Review

Volume: 13   Issue: 2
Pp: 108-125
Shreya Bhattacharya, Shreyeshi Dhar, Arundhati Banerjee and Sujay Ray*
DOI: 10.2174/1874467212666191023123732

Vasorelaxant Effect of Novel Nitric Oxide-Hydrogen Sulfide Donor Chalcone in Isolated Rat Aorta: Involvement of cGMP Mediated sGC and Potassium Channel Activation

Volume: 13   Issue: 2
Pp: 126-136
Amol Sherikar*, Rakesh Dhavale and Manish Bhatia
DOI: 10.2174/1874467212666191025092346

miR-4319 Suppresses the Growth of Esophageal Squamous Cell Carcinoma Via Targeting NLRC5

Volume: 13   Issue: 2
Pp: 144-149
Xiao Hu, Min Wang, Lei Cao, Li Cong, Yujie Gao, Jianwei Lu, Jifeng Feng, Bo Shen and Delin Liu*
DOI: 10.2174/1874467212666191119094636

Therapeutic Targets for the Treatment of Comorbidities Associated with Epilepsy

Volume: 13   Issue: 2
Pp: 85-93
Kinjal Gangar and Lokesh Kumar Bhatt*
DOI: 10.2174/1874467212666191203101606

Therapeutic Promises of Chlorogenic Acid with Special Emphasis on its Anti-Obesity Property

Volume: 13   Issue: 1
Pp: 7-16
Rajnish Kumar, Anju Sharma, Mohammed Shariq Iqbal and Janmejai K. Srivastava*
DOI: 10.2174/1874467212666190716145210

Diazoxide Modulates Cardiac Hypertrophy by Targeting H2O2 Generation and Mitochondrial Superoxide Dismutase Activity

Volume: 13   Issue: 1
Pp: 76-83
Aline Maria Brito Lucas, Joana Varlla de Lacerda Alexandre, Maria Thalyne Silva Araújo, Cicera Edna Barbosa David, Yuana Ivia Ponte Viana, Beatriz Neves Coelho, Francisco Rodrigo Lemos Caldas, Anna Lídia Nunes Varela, Alicia Juliana Kowaltowski and Heberty Tarso Facundo*
DOI: 10.2174/1874467212666190723144006

Protein Tyrosine Phosphatase (PTP1B): A promising Drug Target Against Life-threatening Ailments

Volume: 13   Issue: 1
Pp: 17-30
Ajay Kumar, Divya Rana, Rajat Rana and Rohit Bhatia*
DOI: 10.2174/1874467212666190724150723

The Role of Autophagy in Cancer Radiotherapy

Volume: 13   Issue: 1
Pp: 31-40
Lei Li, Wen-Ling Liu, Lei Su, Zhou-Cheng Lu and Xiu-Sheng He*
DOI: 10.2174/1874467212666190809154518

Mitotherapy as a Novel Therapeutic Strategy for Mitochondrial Diseases

Volume: 13   Issue: 1
Pp: 41-49
Ailing Fu*
DOI: 10.2174/1874467212666190920144115

Hepatic Nuclear Factor 1 Alpha (HNF-1α) In Human Physiology and Molecular Medicine

Volume: 13   Issue: 1
Pp: 50-56
Sumreen Begum*
DOI: 10.2174/1874467212666190930144349

Effects of Adipocyte-derived Factors on the Adrenal Cortex

Volume: 13   Issue: 1
Pp: 2-6
Hiroki Shimada, Erika Noro, Susumu Suzuki, Jun Sakamoto, Ikuko Sato, Rehana Parvin, Atsushi Yokoyama and Akira Sugawara*
DOI: 10.2174/1874467212666191015161334

2-Aminoethyldiphenyl Borinate: A Multitarget Compound with Potential as a Drug Precursor

Volume: 13   Issue: 1
Pp: 57-75
Melvin N. Rosalez, Elizabeth Estevez-Fregoso, Alberto Alatorre, Antonio Abad-García* and Marvin A. Soriano-Ursúa*
DOI: 10.2174/1874467212666191025145429

Preface promotion: free to download

Volume: 13   Issue: 1
Pp: 1-1
Michael Kahn
DOI: 10.2174/187446721301191217124104

Exploring Molecular Approaches in Amyotrophic Lateral Sclerosis: Drug Targets from Clinical and Pre-clinical Findings

Volume: 13   Issue:
Pp: 1-18
Mamtaj Alam, Rajeshwar Kumar Yadav, Elizabeth Minj, Aarti Tiwari and Sidharth Mehan*
DOI: 10.2174/1566524020666200427214356

The Struggle with Rheumatism through Dracunculus vulgaris Schott: In the Light of Ethnobotanical Information

Volume: 13   Issue:
Pp: 1-9
Fatma Tuğçe Gürağaç Dereli, Mert Ilhan and Esra Küpeli Akkol*
DOI: 10.2174/1874467213666200502020345