Abstract
Loss of telomere DNA in normal somatic cells is a major alteration upon ageing. Stem cells and progenitor cells also lose telomere DNA, but at a slower rate than normal cells due to activation of a low level of telomerase activity. Embryonic stem cells exhibit strong telomerase activity, maintain telomere length, and are resistant to DNA damage. In contrast, hematopoietic stem cells, which have weak telomerase activity, are sensitive to DNA damage. The shelterin complex is involved in t-loop formation, a mechanism thought to protect chromosome ends from DNA damage that induces telomere dysfunction. Telomere dysfunction in stem cells brought on by ageing as well as DNA damage has been shown to partake in various age-related diseases. This review illustrates the importance of the telomere end protection mechanism in normal, stem cells and cancer stem cells.
Keywords: Telomere, telomerase, stem cell, DNA damage, anti-cancer drug, cancer stem cell, G-quadruplex
Current Cancer Therapy Reviews
Title: Telomere End Protection in Stem Cells and Cancer Cells
Volume: 4 Issue: 3
Author(s): Hidetoshi Tahara
Affiliation:
Keywords: Telomere, telomerase, stem cell, DNA damage, anti-cancer drug, cancer stem cell, G-quadruplex
Abstract: Loss of telomere DNA in normal somatic cells is a major alteration upon ageing. Stem cells and progenitor cells also lose telomere DNA, but at a slower rate than normal cells due to activation of a low level of telomerase activity. Embryonic stem cells exhibit strong telomerase activity, maintain telomere length, and are resistant to DNA damage. In contrast, hematopoietic stem cells, which have weak telomerase activity, are sensitive to DNA damage. The shelterin complex is involved in t-loop formation, a mechanism thought to protect chromosome ends from DNA damage that induces telomere dysfunction. Telomere dysfunction in stem cells brought on by ageing as well as DNA damage has been shown to partake in various age-related diseases. This review illustrates the importance of the telomere end protection mechanism in normal, stem cells and cancer stem cells.
Export Options
About this article
Cite this article as:
Tahara Hidetoshi, Telomere End Protection in Stem Cells and Cancer Cells, Current Cancer Therapy Reviews 2008; 4 (3) . https://dx.doi.org/10.2174/157339408785294276
DOI https://dx.doi.org/10.2174/157339408785294276 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
Call for Papers in Thematic Issues
Current progress in Protein Degradation and Cancer Therapy
argeted Protein Degradation is gaining momentum in cancer therapy, it facilitate targeting undruggable proteins, it overcome cancer resistance and avoid undesirable side effects. Thus small molecules degraders have emerged as novel therapeutic strategy. Targeted protein degradation (TPD), the process of eliminating a protein of interest hold a great promise for ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Fullerenes for Cancer Diagnosis and Therapy: Preparation, Biological and Clinical Perspectives
Current Drug Metabolism Kinase Phosphorylation-based Mechanisms of PARP Inhibitor Resistance During Synthetic Lethal Oncotherapy
Current Signal Transduction Therapy Evaluation of Drug Transporter Interactions in Drug Discovery and Development
Combinatorial Chemistry & High Throughput Screening Role of Prolyl Isomerase Pin1 in Pathogenesis of Diseases and Remedy for the Diseases from Natural Products
Current Drug Targets Health Outcomes Associated with Hormone Therapy in Australian Women
Current Drug Safety Melatonin: Pharmacology, Functions and Therapeutic Benefits
Current Neuropharmacology Effects of Diet-Derived Molecules on the Tumor Microenvironment
Current Angiogenesis (Discontinued) The Complex Actions of Statins in Brain and their Relevance for Alzheimer`s Disease Treatment: An Analytical Review
Current Alzheimer Research A Knock-Down Cell-Based Study for the Functional Analysis of Chloride Intracellular Channel 1 (CLIC1): Integrated Proteomics and Microarray Study
Protein & Peptide Letters Reactive Oxygen Species, Cancer and Anti-Cancer Therapies
Current Chemical Biology Proinflammatory Cytokines in Breast Cancer: Mechanisms of Action and Potential Targets for Therapeutics
Current Drug Targets Ginkgo biloba as an Alternative Medicine in the Treatment of Anxiety in Dementia and other Psychiatric Disorders
Current Drug Metabolism Non-Analgesic Effects of Opioids: Opioids and the Endocrine System
Current Pharmaceutical Design Epoxyeicosatrienoic Acids as a Therapeutic Target for Nephropathy Associated with Diabetes and Hypertension
Current Hypertension Reviews Design, Synthesis and Evaluation of Hybrid 2-Heteroaryl Benzimidazole- Chalcone Derivatives as Anticancer Agents
Letters in Organic Chemistry Factors Associated with Pulmonary Embolism Recurrence and the Benefits of Long-term Anticoagulant Therapy
Cardiovascular & Hematological Disorders-Drug Targets Assessment of Nutritional Status in Cancer – The Relationship Between Body Composition and Pharmacokinetics
Anti-Cancer Agents in Medicinal Chemistry A Review of the Primer Approximation Multiplex PCR (PAMP) Technique for Detecting Large Scale Cancer Genomic Lesions
Current Bioinformatics Opinion Paper: Promise and Pragmatism in Clinical Microbiome Research
Mini-Reviews in Medicinal Chemistry The Immune Protective Effect of the Mediterranean Diet against Chronic Low-grade Inflammatory Diseases
Endocrine, Metabolic & Immune Disorders - Drug Targets