Abstract
Sp-family transcription factors are widely expressed in human tissues and involved in the regulation of many cellular processes and response to cellular microenvironment. These responses appear to be mediated by alterations in transcription factor affinity for DNA rather than altered protein level. How might such changes be effected? This review will identify the range of known post-translational modifications (PTMs) of Sp-factors and the sometimes conflicting literature about the roles of PTMs in regulating activity. We will speculate on the interaction between cell environment, chromatin microenvironment and the role of PTM in governing functionality of the proteins and the complexes to which they belong.
Keywords: Sp family, Sp1, Sp3 phosphorylation, acetylation, glycosylation, sumolation
Current Genomics
Title: Post-Translational Control of Sp-Family Transcription Factors
Volume: 9 Issue: 5
Author(s): J. S. Waby, C. D. Bingle and B. M. Corfe
Affiliation:
Keywords: Sp family, Sp1, Sp3 phosphorylation, acetylation, glycosylation, sumolation
Abstract: Sp-family transcription factors are widely expressed in human tissues and involved in the regulation of many cellular processes and response to cellular microenvironment. These responses appear to be mediated by alterations in transcription factor affinity for DNA rather than altered protein level. How might such changes be effected? This review will identify the range of known post-translational modifications (PTMs) of Sp-factors and the sometimes conflicting literature about the roles of PTMs in regulating activity. We will speculate on the interaction between cell environment, chromatin microenvironment and the role of PTM in governing functionality of the proteins and the complexes to which they belong.
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Cite this article as:
Waby S. J., Bingle D. C. and Corfe M. B., Post-Translational Control of Sp-Family Transcription Factors, Current Genomics 2008; 9 (5) . https://dx.doi.org/10.2174/138920208785133244
DOI https://dx.doi.org/10.2174/138920208785133244 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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