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Current Drug Targets

Editor-in-Chief

ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

The “Classical” Ovalbumin Challenge Model of Asthma in Mice

Author(s): Rakesh K. Kumar, Cristan Herbert and Paul S. Foster

Volume 9, Issue 6, 2008

Page: [485 - 494] Pages: 10

DOI: 10.2174/138945008784533561

Price: $65

Abstract

Ovalbumin challenge models of asthma offer many opportunities for increasing our understanding of the pathogenetic mechanisms underlying this disease, as well as for identifying novel therapeutic targets. There is no single “classical” model, because numerous alternatives exist with respect to the choice of mouse strain, method of sensitisation, route and duration of challenge, and approach to assessing the host response. Moreover, the limitations of these models need to be recognised when attempting to interpret experimental findings. Nevertheless, careful use of well-defined models allows investigators to answer specific questions that are otherwise difficult to address.

Keywords: Asthma, animal models, airway inflammation, airway hyper-responsiveness, airway remodelling


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