Abstract
Experimental guinea pig asthma is a reliable and clinically relevant facsimile of human disease. The guinea pig is the preferred choice for use as a model of allergic bronchial asthma in the evaluation of anti-asthmatic drugs, since the airway anatomy and the response to inflammatory mediators is similar to humans. Further, the great strength of this model is the direct anaphylactic bronchoconstriction upon antigen challenge. Under certain conditions a late asthmatic response can be measured and airway hyperresponsiveness is observed in vitro and in vivo. Moreover, the inflammatory response is comparable with the human situation. More recent studies describe a chronic model for asthma in which airway remodeling is induced as can be observed in the asthmatic patients. The focus here is to demonstrate that guinea pig asthma models are useful for testing novel therapeutics.
Keywords: Allergy, asthma, guinea pig, early asthmatic reaction, late asthmatic reaction, airway hyperresponsiveness, airway inflammation, airway remodelling
Current Drug Targets
Title: The Guinea Pig as an Animal Model for Asthma
Volume: 9 Issue: 6
Author(s): Fabio L.M. Ricciardolo, Frans Nijkamp, Virginia De Rose and Gert Folkerts
Affiliation:
Keywords: Allergy, asthma, guinea pig, early asthmatic reaction, late asthmatic reaction, airway hyperresponsiveness, airway inflammation, airway remodelling
Abstract: Experimental guinea pig asthma is a reliable and clinically relevant facsimile of human disease. The guinea pig is the preferred choice for use as a model of allergic bronchial asthma in the evaluation of anti-asthmatic drugs, since the airway anatomy and the response to inflammatory mediators is similar to humans. Further, the great strength of this model is the direct anaphylactic bronchoconstriction upon antigen challenge. Under certain conditions a late asthmatic response can be measured and airway hyperresponsiveness is observed in vitro and in vivo. Moreover, the inflammatory response is comparable with the human situation. More recent studies describe a chronic model for asthma in which airway remodeling is induced as can be observed in the asthmatic patients. The focus here is to demonstrate that guinea pig asthma models are useful for testing novel therapeutics.
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Cite this article as:
Ricciardolo L.M. Fabio, Nijkamp Frans, Rose De Virginia and Folkerts Gert, The Guinea Pig as an Animal Model for Asthma, Current Drug Targets 2008; 9 (6) . https://dx.doi.org/10.2174/138945008784533534
DOI https://dx.doi.org/10.2174/138945008784533534 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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