Abstract
Paclitaxil is a non-water soluble anti-cancer drug with problems of solvent related toxicities due to use of ethanol and polyethylated castor-oil for administration. Several formulations have been prepared to overcome the solubility problem and the present work describes one of such possibility of the preparation of water-soluble paclitaxil nanoparticles by Emulsion-solvent evaporation technique. The paclitaxil nanoparticles were prepared by nanoemulsification using human serum albumin as polymer. The prepared nanoparticles were evaluated by stability studies, encapsulating efficiency, in-vitro toxicity studies. It aims to verify the in vivo capacity of the formed nanoparticles to reduce the toxicity, which would have been caused by the conventional Cremophor EL. The prepared nanoparticles were soluble in 0.9%NaCl, showed better encapsulating efficiency and the reconstituted solution was stable for more than 24 hrs. In-vivo abnormal toxicity studies were carried out on albino mice and guinea pig and showed that the paclitaxilnanoparticles formed had no toxicity as compared to Cremophor EL.
Keywords: Nanoparticles, albumin, reduced toxicity, paclitaxil, homogenization, bio-degradable, stability, lyophilization
Current Bioactive Compounds
Title: Preparation of Water-Soluble Albumin Loaded Paclitaxil Nanoparticles Using Emulsion-Solvent Evaporation Technique
Volume: 4 Issue: 1
Author(s): A. Anil Yadav and Shanthi Vadali
Affiliation:
Keywords: Nanoparticles, albumin, reduced toxicity, paclitaxil, homogenization, bio-degradable, stability, lyophilization
Abstract: Paclitaxil is a non-water soluble anti-cancer drug with problems of solvent related toxicities due to use of ethanol and polyethylated castor-oil for administration. Several formulations have been prepared to overcome the solubility problem and the present work describes one of such possibility of the preparation of water-soluble paclitaxil nanoparticles by Emulsion-solvent evaporation technique. The paclitaxil nanoparticles were prepared by nanoemulsification using human serum albumin as polymer. The prepared nanoparticles were evaluated by stability studies, encapsulating efficiency, in-vitro toxicity studies. It aims to verify the in vivo capacity of the formed nanoparticles to reduce the toxicity, which would have been caused by the conventional Cremophor EL. The prepared nanoparticles were soluble in 0.9%NaCl, showed better encapsulating efficiency and the reconstituted solution was stable for more than 24 hrs. In-vivo abnormal toxicity studies were carried out on albino mice and guinea pig and showed that the paclitaxilnanoparticles formed had no toxicity as compared to Cremophor EL.
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Cite this article as:
Yadav Anil A. and Vadali Shanthi, Preparation of Water-Soluble Albumin Loaded Paclitaxil Nanoparticles Using Emulsion-Solvent Evaporation Technique, Current Bioactive Compounds 2008; 4 (1) . https://dx.doi.org/10.2174/157340708784533410
DOI https://dx.doi.org/10.2174/157340708784533410 |
Print ISSN 1573-4072 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6646 |
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