Abstract
There is increasing evidence that certain probiotic strains can be useful in improving human health. The use of probiotics has received attention as a natural way of restoring bodys normal microbiota, and an alternative and inexpensive way of preventing or treating infectious diseases without side effects. The best-documented clinical application of probiotics comes from trials on the treatment of gastrointestinal infections, mainly infectious diarrhoea. The enhancement of local as well as systemic immune responses by probiotics also offers new opportunities for probiotics in preventing infections at distal mucosal surfaces, such as those in the oral cavity, respiratory and urogenital tracts. The underlying mechanisms of probiotics are still unclear, but may include strengthening of the non-immunological gut barrier, interference with pathogen adhesion and growth inhibition, and the enhancement of the local mucosal immune system in the gut, as well as of the systemic immune response.
Keywords: Probiotics, Lactobacillus, Bifidobacterium, gastrointestinal, oral, respiratory, urogenital, infection
Current Pharmaceutical Design
Title: Probiotics in Intestinal and Non-Intestinal Infectious Diseases – Clinical Evidence
Volume: 14 Issue: 14
Author(s): K. Hatakka and M. Saxelin
Affiliation:
Keywords: Probiotics, Lactobacillus, Bifidobacterium, gastrointestinal, oral, respiratory, urogenital, infection
Abstract: There is increasing evidence that certain probiotic strains can be useful in improving human health. The use of probiotics has received attention as a natural way of restoring bodys normal microbiota, and an alternative and inexpensive way of preventing or treating infectious diseases without side effects. The best-documented clinical application of probiotics comes from trials on the treatment of gastrointestinal infections, mainly infectious diarrhoea. The enhancement of local as well as systemic immune responses by probiotics also offers new opportunities for probiotics in preventing infections at distal mucosal surfaces, such as those in the oral cavity, respiratory and urogenital tracts. The underlying mechanisms of probiotics are still unclear, but may include strengthening of the non-immunological gut barrier, interference with pathogen adhesion and growth inhibition, and the enhancement of the local mucosal immune system in the gut, as well as of the systemic immune response.
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Cite this article as:
Hatakka K. and Saxelin M., Probiotics in Intestinal and Non-Intestinal Infectious Diseases – Clinical Evidence, Current Pharmaceutical Design 2008; 14 (14) . https://dx.doi.org/10.2174/138161208784480162
DOI https://dx.doi.org/10.2174/138161208784480162 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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