Abstract
A new method was developed for the determination of lomefloxacin by using flow – injection chemiluminescence( CL) based on the reaction of Ce(IV) – sodium thiosulfate – lomefloxacin – sulfuric acid system. The CL conditions were investigated and optimized. The CL intensity was correlated linearly with concentration of lomefloxacin in the range of 1.0x10-5∼6.0x10-2 g L-1. The determination limit (3) is 3x10-6 g L-1. The relative standard deviation is 1.9% for 11 measurements of 2.0x10-4 g L-1 lomefloxacin. The method has been applied satisfactorily to determine lomefloxacin in drugs, serum and urine with the recovery of 97.0%∼104.5%. The CL mechanism of the system was proposed.
Keywords: Lomefloxacin, Chemiluminescence, Fluorescence, Flow-injection, Pharmaceutical analysis, Biological fluids
Current Analytical Chemistry
Title: Flow-Injection Chemiluminescence Analysis of Lomefloxacin in Drugs and Biological Fluids
Volume: 4 Issue: 2
Author(s): Liqing Li, Hanwen Sun and Xueyan Chen
Affiliation:
Keywords: Lomefloxacin, Chemiluminescence, Fluorescence, Flow-injection, Pharmaceutical analysis, Biological fluids
Abstract: A new method was developed for the determination of lomefloxacin by using flow – injection chemiluminescence( CL) based on the reaction of Ce(IV) – sodium thiosulfate – lomefloxacin – sulfuric acid system. The CL conditions were investigated and optimized. The CL intensity was correlated linearly with concentration of lomefloxacin in the range of 1.0x10-5∼6.0x10-2 g L-1. The determination limit (3) is 3x10-6 g L-1. The relative standard deviation is 1.9% for 11 measurements of 2.0x10-4 g L-1 lomefloxacin. The method has been applied satisfactorily to determine lomefloxacin in drugs, serum and urine with the recovery of 97.0%∼104.5%. The CL mechanism of the system was proposed.
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Cite this article as:
Li Liqing, Sun Hanwen and Chen Xueyan, Flow-Injection Chemiluminescence Analysis of Lomefloxacin in Drugs and Biological Fluids, Current Analytical Chemistry 2008; 4 (2) . https://dx.doi.org/10.2174/157341108784587849
DOI https://dx.doi.org/10.2174/157341108784587849 |
Print ISSN 1573-4110 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6727 |
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