Aminobisphosphonates as New Weapons for γ δ T Cell-Based Immunotherapy of Cancer

Title: Aminobisphosphonates as New Weapons for γ δ T Cell-Based Immunotherapy of Cancer

Volume: 15 Issue: 12

Author(s): Nadia Caccamo, Serena Meraviglia, Giuseppe Cicero, Gaspare Gulotta, Francesco Moschella, Adriana Cordova, Eliana Gulotta, Alfredo Salerno and Francesco Dieli

Affiliation:

Keywords: Human γ δ T cells, tumors, phosphoantigens, bisphosphonates, immunotherapy

Abstract: Several observations in mice and in humans have collectively laid the foundation for examining the potential of γ δ T cells to exert tumor immunotherapy. Human γ δ T cells can be activated in a non-MHC dependent fashion either by low molecular mass phosphoantigens, or by agents that provoke the accumulation of endogenous pyrophosphates such as isopentenylpyrophosphate. Among the latter, aminobisphosphonates are well-established in the clinic, and extensive data are available on the compounds antiangiogenic, antiosteolytic and pro-apoptotic properties. In this review we discuss on the possibility that the intentional activation of γ δ T cells in vivo by aminobisphosphonates may represent a promising target for the design of novel and highly innovative immunotherapy in patients with different types of cancer.

Cite this article as:

Caccamo Nadia, Meraviglia Serena, Cicero Giuseppe, Gulotta Gaspare, Moschella Francesco, Cordova Adriana, Gulotta Eliana, Salerno Alfredo and Dieli Francesco, Aminobisphosphonates as New Weapons for γ δ T Cell-Based Immunotherapy of Cancer, Current Medicinal Chemistry 2008; 15 (12) . https://dx.doi.org/10.2174/092986708784310468