Abstract
HspB5/αB-crystallin (αBC), one of the most representative member of mammalian small heat shock protein family (sHsp), shares the common features with other nine members HspB1-B4 and HspB6-10. Meanwhile, it has a strong antiapoptic effect; its interaction with cytoskeleton participates in maintaining cell structure and plays an important role in cytoprotection. Recent studies reveal that HspB5 has a strong relationship with neurological diseases acting as a protective molecular chaperone or in certain conditions, a pathogenic factor. This review gives a brief introduction on properties of HspB5, its current progress in neurological diseases and potential therapeutic intervention in demyelinating disease, neurodegenerative disease, myopathy and cerebrovascular disease.
Keywords: HspB5/αB-crystallin, property, apoptosis, cytoskeleton, neurological disease, multiple sclerosis, ischemia/reperfusion injury, therapeutic intervention
Current Neurovascular Research
Title: HspB5/αB-Crystallin: Properties and Current Progress in Neuropathy
Volume: 5 Issue: 2
Author(s): Zhiping Hu and Ting Li
Affiliation:
Keywords: HspB5/αB-crystallin, property, apoptosis, cytoskeleton, neurological disease, multiple sclerosis, ischemia/reperfusion injury, therapeutic intervention
Abstract: HspB5/αB-crystallin (αBC), one of the most representative member of mammalian small heat shock protein family (sHsp), shares the common features with other nine members HspB1-B4 and HspB6-10. Meanwhile, it has a strong antiapoptic effect; its interaction with cytoskeleton participates in maintaining cell structure and plays an important role in cytoprotection. Recent studies reveal that HspB5 has a strong relationship with neurological diseases acting as a protective molecular chaperone or in certain conditions, a pathogenic factor. This review gives a brief introduction on properties of HspB5, its current progress in neurological diseases and potential therapeutic intervention in demyelinating disease, neurodegenerative disease, myopathy and cerebrovascular disease.
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Cite this article as:
Hu Zhiping and Li Ting, HspB5/αB-Crystallin: Properties and Current Progress in Neuropathy, Current Neurovascular Research 2008; 5 (2) . https://dx.doi.org/10.2174/156720208784310222
DOI https://dx.doi.org/10.2174/156720208784310222 |
Print ISSN 1567-2026 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5739 |
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