Abstract
Whilst the scientific community was celebrating the truly momentous discovery of a ‘mixed function oxidase’ another oxidase was quietly working behind the scenes, mopping up soft nucleophiles and, as it had undoubtedly being doing for aeons, aiding then unknown in the metabolism of xenobiotics and the protection of life forms. This enzyme, flavin mono-oxygenase, has subsequently been shown to be a major player, if not yet an equal partner with cytochrome(s) P450, in the metabolism of both endogenous biochemicals and foreign compounds that enter the human organism. This article outlines the importance of the flavin mono-oxygenases and examines their susceptibility to activity modulation by exogenous factors.
Keywords: Flavin mono-oxygenase, Zeigler's enzyme, trimethylamine, fish-odour syndrome, hormones, cruciferous vegetables
Current Drug Metabolism
Title: Flavin Mono-Oxygenase (FMO) - The ‘Other’ Oxidase
Volume: 9 Issue: 4
Author(s): S. C. Mitchell
Affiliation:
Keywords: Flavin mono-oxygenase, Zeigler's enzyme, trimethylamine, fish-odour syndrome, hormones, cruciferous vegetables
Abstract: Whilst the scientific community was celebrating the truly momentous discovery of a ‘mixed function oxidase’ another oxidase was quietly working behind the scenes, mopping up soft nucleophiles and, as it had undoubtedly being doing for aeons, aiding then unknown in the metabolism of xenobiotics and the protection of life forms. This enzyme, flavin mono-oxygenase, has subsequently been shown to be a major player, if not yet an equal partner with cytochrome(s) P450, in the metabolism of both endogenous biochemicals and foreign compounds that enter the human organism. This article outlines the importance of the flavin mono-oxygenases and examines their susceptibility to activity modulation by exogenous factors.
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Cite this article as:
Mitchell C. S., Flavin Mono-Oxygenase (FMO) - The ‘Other’ Oxidase, Current Drug Metabolism 2008; 9 (4) . https://dx.doi.org/10.2174/138920008784220682
DOI https://dx.doi.org/10.2174/138920008784220682 |
Print ISSN 1389-2002 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5453 |
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