In Vitro Antioxidant Capacity vs In Vivo Antimetastatic Effect of Anticancer Cobalt Complexes

Title: In Vitro Antioxidant Capacity vs In Vivo Antimetastatic Effect of Anticancer Cobalt Complexes

Volume: 4 Issue: 2

Author(s): Luigi Campanella, Gabriele Favero, Sergey P. Osinsky, Andrej L. Sigan and Mauro Tomassetti

Affiliation:

Keywords: superoxide dismutase, ORAC Spectrofluorimetric Method, Differential Pulse Voltammetry, pH value, antioxidant

Abstract: Four different methods were used to measure the “in vitro” antioxidant capacity of three cobalt complexes recently proposed as anticancer active principles: a new biosensor method and a new pulse voltammetric, or pulse polarographic method, together with two other methods - one fluorimetric and the other spectrophotometric. Results obtained using the different methods are discussed and compared with the anti-metastatic effect recently measured “in vivo” by Russian authors. The good correlation found between anti-tumoral and anti-metastatic activity ranking and in vitro antioxidant activity found by the new voltammetric method suggests interesting hypotheses based on the anti-tumoral effect of these complexes.

Cite this article as:

Campanella Luigi, Favero Gabriele, Osinsky P. Sergey, Sigan L. Andrej and Tomassetti Mauro, In Vitro Antioxidant Capacity vs In Vivo Antimetastatic Effect of Anticancer Cobalt Complexes, Current Pharmaceutical Analysis 2008; 4 (2) . https://dx.doi.org/10.2174/157341208784246279