Abstract
The status of adipose tissue changes rapidly. From a simple filler tissue, it successively acquires the status of metabolic active tissue, endocrine tissue, plastic tissue, and finally that of a large reservoir of cells suitable for cell therapy and regenerative medicine. All throughout this story, our knowledge has been largely dependent on genetic tools and gene transfer. Now, the time has come where gene transfer in adipose derived cells can be envisioned, not only for understanding the role or importance of one gene, but also to engineer adipose derived cells for the purpose of therapy by delivering secreted products. In this paper, after a brief overview of adipose tissues, a large part will be devoted to the use of virusbased gene transfer in transducing adipose tissue and cells which reside therein. We also critically review the use of adipose “specific” promoters and the applications already described in the literature.
Keywords: Adipose tissue, preadipocytes, adipose derived cells, virus, promoter, shRNA, cell therapy
Current Gene Therapy
Title: Virus-based Gene Transfer Approaches and Adipose Tissue Biology
Volume: 8 Issue: 2
Author(s): Louis Casteilla, Beatrice Cousin, Valerie Planat-Benard, Patrick Laharrague, Mamen Carmona and Luc Penicaud
Affiliation:
Keywords: Adipose tissue, preadipocytes, adipose derived cells, virus, promoter, shRNA, cell therapy
Abstract: The status of adipose tissue changes rapidly. From a simple filler tissue, it successively acquires the status of metabolic active tissue, endocrine tissue, plastic tissue, and finally that of a large reservoir of cells suitable for cell therapy and regenerative medicine. All throughout this story, our knowledge has been largely dependent on genetic tools and gene transfer. Now, the time has come where gene transfer in adipose derived cells can be envisioned, not only for understanding the role or importance of one gene, but also to engineer adipose derived cells for the purpose of therapy by delivering secreted products. In this paper, after a brief overview of adipose tissues, a large part will be devoted to the use of virusbased gene transfer in transducing adipose tissue and cells which reside therein. We also critically review the use of adipose “specific” promoters and the applications already described in the literature.
Export Options
About this article
Cite this article as:
Casteilla Louis, Cousin Beatrice, Planat-Benard Valerie, Laharrague Patrick, Carmona Mamen and Penicaud Luc, Virus-based Gene Transfer Approaches and Adipose Tissue Biology, Current Gene Therapy 2008; 8 (2) . https://dx.doi.org/10.2174/156652308784049354
DOI https://dx.doi.org/10.2174/156652308784049354 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
Call for Papers in Thematic Issues
Programmed Cell Death Genes in Oncology: Pioneering Therapeutic and Diagnostic Frontiers (BMS-CGT-2024-HT-45)
Programmed Cell Death (PCD) is recognized as a pivotal biological mechanism with far-reaching effects in the realm of cancer therapy. This complex process encompasses a variety of cell death modalities, including apoptosis, autophagic cell death, pyroptosis, and ferroptosis, each of which contributes to the intricate landscape of cancer development and ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Oligonucleotide-Based Molecular Therapy for Restenosis after Angioplasty
Current Drug Targets Epstein-Barr Virus-associated Gastric Cancer and Potential Mechanisms of Oncogenesis
Current Cancer Drug Targets Systemic DNA Damage Response and Metabolic Syndrome as a Premalignant State
Current Molecular Medicine Fork Head Transcription Factors
Current Genomics Recurrence in Bladder Cancer: A Molecular Dead End?
Current Genomics Rb at the Interface Between Cell Cycle and Apoptotic Decisions
Current Molecular Medicine Mitochondrial Signaling and Hepatocellular Carcinoma: Molecular Mechanisms and Therapeutic Implications
Current Pharmaceutical Design Regulatory Circuitries Coordinated by Transcription Factors and microRNAs at the Cornerstone of Hematopoietic Stem Cell Self-Renewal and Differentiation
Current Stem Cell Research & Therapy Multi-Kinase Inhibitors
Current Medicinal Chemistry Nutlins and Ionizing Radiation in Cancer Therapy
Current Pharmaceutical Design Anticancer Therapeutic Strategies Based on CDK Inhibitors
Current Pharmaceutical Design Epigenetic Targets and their Inhibitors in Cancer Therapy
Current Topics in Medicinal Chemistry Antitumor Activity of Novel Benzensulfonamide Derivatives in View of their Physiochemical Properties Searched by Principal Component Analysis
Medicinal Chemistry Cellular Mechanisms of Bypass Vein Graft Arterialization and Approaches to Attenuate Graft Remodeling
Vascular Disease Prevention (Discontinued) Microarray Profiling Analysis Uncovers Common Molecular Mechanisms of Rubella Virus, Human Cytomegalovirus, and Herpes Simplex Virus Type 2 Infections in ECV304 Cells
Current Molecular Medicine Small Molecule CDK Inhibitors for the Therapeutic Management of Cancer
Current Topics in Medicinal Chemistry Histone Lysine-Specific Methyltransferases and Demethylases in Carcinogenesis: New Targets for Cancer Therapy and Prevention
Current Cancer Drug Targets Novel Therapeutic Approaches to Regulate Human Dihydrofolate Reductase Activity and Expression
Current Enzyme Inhibition Genetic Predisposition to Neonatal Tumors
Current Pediatric Reviews Targeting Nanomedicine to Brain Tumors: Latest Progress and Achievements
Current Pharmaceutical Design