Abstract
While increasing antioxidant potential is an attractive treatment strategy for diabetic neuropathy, many years of trials using high-dose oral antioxidants have not produced therapeutic results. An increasing understanding of the innate antioxidant response and the pharmacological agents that can regulate this mechanism may open new avenue for drug development. This review describes the current state of antioxidant trials and the potential for targeting the antioxidant response. In combination with antihyperglycemic agents, agents that regulate the antioxidant response may afford superior protection against cellular oxidative injury in diabetes.
Keywords: dorsal root ganglia, Nrf2 protein, hyperglycemia, oxidative stress, advanced glycation products
Current Drug Targets
Title: The Antioxidant Response as a Drug Target in Diabetic Neuropathy
Volume: 9 Issue: 1
Author(s): Andrea M. Vincent, James L. Edwards, Mahdieh Sadidi and Eva L. Feldman
Affiliation:
Keywords: dorsal root ganglia, Nrf2 protein, hyperglycemia, oxidative stress, advanced glycation products
Abstract: While increasing antioxidant potential is an attractive treatment strategy for diabetic neuropathy, many years of trials using high-dose oral antioxidants have not produced therapeutic results. An increasing understanding of the innate antioxidant response and the pharmacological agents that can regulate this mechanism may open new avenue for drug development. This review describes the current state of antioxidant trials and the potential for targeting the antioxidant response. In combination with antihyperglycemic agents, agents that regulate the antioxidant response may afford superior protection against cellular oxidative injury in diabetes.
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Cite this article as:
Vincent M. Andrea, Edwards L. James, Sadidi Mahdieh and Feldman L. Eva, The Antioxidant Response as a Drug Target in Diabetic Neuropathy, Current Drug Targets 2008; 9 (1) . https://dx.doi.org/10.2174/138945008783431754
DOI https://dx.doi.org/10.2174/138945008783431754 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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