Abstract
In the past 20 years, photosensitisers have found a niche in the photodynamic treatment of accessible tumours (PDT). Most of the therapeutics involved in this approach are porphyrin-based natural products or derivatives. However, there is a range of other photodynamic agents derived from natural sources – either via direct extraction/purification, or via semisynthesis - currently being trialled both for anticancer PDT and the related antimicrobial application, covering areas such as wound disinfection and blood product sterilisation. The following review covers the advances made in the potential photoantimicrobial application of natural product photosensitisers and their derivatives.
Keywords: Antimicrobial, photosensitiser, singlet oxygen, porphyrin, perylenequinonoid, anthraquinone, isoquinoline, furocoumarin
Current Bioactive Compounds
Title: Natural Product Photoantimicrobials
Volume: 3 Issue: 4
Author(s): M. Wainwright
Affiliation:
Keywords: Antimicrobial, photosensitiser, singlet oxygen, porphyrin, perylenequinonoid, anthraquinone, isoquinoline, furocoumarin
Abstract: In the past 20 years, photosensitisers have found a niche in the photodynamic treatment of accessible tumours (PDT). Most of the therapeutics involved in this approach are porphyrin-based natural products or derivatives. However, there is a range of other photodynamic agents derived from natural sources – either via direct extraction/purification, or via semisynthesis - currently being trialled both for anticancer PDT and the related antimicrobial application, covering areas such as wound disinfection and blood product sterilisation. The following review covers the advances made in the potential photoantimicrobial application of natural product photosensitisers and their derivatives.
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Cite this article as:
Wainwright M., Natural Product Photoantimicrobials, Current Bioactive Compounds 2007; 3 (4) . https://dx.doi.org/10.2174/157340707783220202
DOI https://dx.doi.org/10.2174/157340707783220202 |
Print ISSN 1573-4072 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6646 |
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