Abstract
Dietary n-3 fatty acids and calorie restriction are well known immunomodulatory nutrients. Recent data from our laboratory has shown that combining n-3 fatty acids and calorie restriction is more potent at delaying autoimmune disease in mice than either dietary regimen alone. Interestingly, autoimmune disease has some unique effects on lymphocyte subsets and Th-1 (interleukin- 2, interferon-γ ) and Th-2 (interleukin-10 and -5) cytokine and immunoglobulin (IgA and IgE) production when comparing the peripheral blood with the spleen, mesenteric lymph nodes and salivary glands. However, regardless of the variable changes that occur due to n-6 and n-3 fatty acids, the combination of dietary n-3 fatty acids and/or calorie restriction prevents immune cell dysregulation. Extensive studies conducted in spleen T-cells have shown that diet, in the absence of pharmacologic or genetic manipulation, has a dramatic impact on preventing alterations in apoptosis, memory cell populations, and nuclear factor kappa B activation associated with autoimmune disease. The results discussed here also show striking similarities to aging in healthy mice like reduced interleukin-2 production and increased memory T-lymphocytes suggesting a clear link between normal aging and the early development of autoimmune disease. Future dietary studies examining several different immune compartments simultaneously are likely to yield exciting new data on the impact of diet and drug therapy on autoimmune disorders in various target tissues such as kidney and salivary glands.
Current Organic Chemistry
Title: Dietary N-3 Fatty Acids and Calorie Restriction in Autoimmune Disease:Influence in Different Immune Compartments
Volume: 4 Issue: 11
Author(s): Christopher A. Jolly and Gabriel Fernandes
Affiliation:
Abstract: Dietary n-3 fatty acids and calorie restriction are well known immunomodulatory nutrients. Recent data from our laboratory has shown that combining n-3 fatty acids and calorie restriction is more potent at delaying autoimmune disease in mice than either dietary regimen alone. Interestingly, autoimmune disease has some unique effects on lymphocyte subsets and Th-1 (interleukin- 2, interferon-γ ) and Th-2 (interleukin-10 and -5) cytokine and immunoglobulin (IgA and IgE) production when comparing the peripheral blood with the spleen, mesenteric lymph nodes and salivary glands. However, regardless of the variable changes that occur due to n-6 and n-3 fatty acids, the combination of dietary n-3 fatty acids and/or calorie restriction prevents immune cell dysregulation. Extensive studies conducted in spleen T-cells have shown that diet, in the absence of pharmacologic or genetic manipulation, has a dramatic impact on preventing alterations in apoptosis, memory cell populations, and nuclear factor kappa B activation associated with autoimmune disease. The results discussed here also show striking similarities to aging in healthy mice like reduced interleukin-2 production and increased memory T-lymphocytes suggesting a clear link between normal aging and the early development of autoimmune disease. Future dietary studies examining several different immune compartments simultaneously are likely to yield exciting new data on the impact of diet and drug therapy on autoimmune disorders in various target tissues such as kidney and salivary glands.
Export Options
About this article
Cite this article as:
Jolly A. Christopher and Fernandes Gabriel, Dietary N-3 Fatty Acids and Calorie Restriction in Autoimmune Disease:Influence in Different Immune Compartments, Current Organic Chemistry 2000; 4 (11) . https://dx.doi.org/10.2174/1385272003375842
DOI https://dx.doi.org/10.2174/1385272003375842 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Cytokines as Novel Therapeutic Agents for Neuroinflammatory Disorders: A Role for Interferon-β in the Treatment of Multiple Sclerosis
Current Medicinal Chemistry - Central Nervous System Agents Synthetic Glycolipid Ligands for Human iNKT Cells as Potential Therapeutic Agents for Immunotherapy
Current Medicinal Chemistry Microchimerism in Health and Disease
Current Molecular Medicine From Cannabis to Endocannabinoids in Multiple Sclerosis: A Paradigm of Central Nervous System Autoimmune Diseases
Current Drug Targets - CNS & Neurological Disorders The AKT Axis as a Therapeutic Target in Autoimmune Diseases
Endocrine, Metabolic & Immune Disorders - Drug Targets Therapeutic Monitoring of Immunotherapies in Autoimmune Diseases
Current Pharmaceutical Design Is Autoimmunity a Component of Natural Immunity to HIV?
Current HIV Research Potassium Channel Blockade by the Sea Anemone Toxin ShK for the Treatment of Multiple Sclerosis and Other Autoimmune Diseases
Current Medicinal Chemistry siRNA Delivery Using Nanocarriers – An Efficient Tool for Gene Silencing
Current Gene Therapy Clinical Applications and Biosafety of Human Adult Mesenchymal Stem Cells
Current Pharmaceutical Design Serological Electrodetection of Rheumatoid Arthritis Using Mimetic Peptide
Protein & Peptide Letters Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Medical and Societal Impact
Current Immunology Reviews (Discontinued) The Role of HLA Promoters in Autoimmunity
Current Pharmaceutical Design The Role of Infections in the Pathogenesis of Autoimmune Diseases
Current Drug Targets - Inflammation & Allergy Modulation of TNF Receptor Family Members to Inhibit Autoimmune Disease
Current Drug Targets - Inflammation & Allergy Application of Agents Against Interferon-Gamma-Dependent Chemokines in Immunotherapy
Letters in Drug Design & Discovery Defective Autophagy in Fibroblasts May Contribute to Fibrogenesis in Autoimmune Processes
Current Pharmaceutical Design IL-27: Friend or Foe in the Autoimmune Diseases
Current Immunology Reviews (Discontinued) Oral Tolerance in the Treatment of Rheumatoid Arthritis
Current Drug Targets - Inflammation & Allergy Regulation of Self-Reactive T Cells by Human Immunoglobulins- Implications for Multiple Sclerosis Therapy
Current Pharmaceutical Design