Chemoselective High-Throughput Purification Mediated by Solid-Supported Reagents Its Application to the First 6,9-Disubstituted Purine Library Synthesis

Title: Chemoselective High-Throughput Purification Mediated by Solid-Supported Reagents Its Application to the First 6,9-Disubstituted Purine Library Synthesis

Volume: 3 Issue: 2

Author(s): Kyungjin Kim and Warren McComas

Affiliation:

Keywords: Chemoselective High throughput purification, Solid supported reagents, 6,9 disubstituted purine library synthesis

Abstract: A new application of solid-supported reagents was developed to separate the alkylated N7 N9 regioisomers derived from commercially available 2-amino-6-chloropurine. Simple filtration through an alumina H positive pad or scavenging by AG Dowex-50W-X8 resin provides diverse N9 regioisomers selectively in moderate yields with high purities (less than90 percent). This purification method can be conveniently used in a high-throughput format and facilitates the synthesis of a purine library without laborious regioisomer separation and aqueous work-up. The first library synthesis of 6,9-disubstituted purines is reported using the combination of this novel separation method in conjunction with polymer-supported reagents.

Cite this article as:

Kim Kyungjin and McComas Warren, Chemoselective High-Throughput Purification Mediated by Solid-Supported Reagents Its Application to the First 6,9-Disubstituted Purine Library Synthesis, Combinatorial Chemistry & High Throughput Screening 2000; 3 (2) . https://dx.doi.org/10.2174/1386207003331779