Hepatic Cytochrome P450 Regulation in Disease States

Po-Yung      Cheng; Edward   T.   Morgan

Abstract

Hepatic cytochrome P450 (P450) enzyme activities and gene expression can be profoundly altered in disease states. In general the levels of affected hepatic P450 enzymes are depressed by diseases, causing potential and documented impairment of drug clearance and clinical drug toxicity. However, modulation of P450s is enzyme selective and this selectivity differs among different diseases. This review will concentrate on regulation of P450s in diabetes, obesity and infectious and inflammatory disease, conditions that affect millions of people worldwide every day.

Keywords: Hepatic cytochrome P450, DIABETES AND OBESITY, CYP4A, CYP2E1, Hepatic P450s, LIVER DISEASES, INFLAMMATION AND INFECTION, Nitric Oxide, AhR-Regulated Genes, Peroxisome proliferator activated receptor, Aryl hydrocarbon receptor, Napthoflavone, Onstitutive androstane receptor, Interferon, Interleukin, Nitric oxide synthase, Tumor necrosis factor, Pregnane X receptor