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Current Pharmaceutical Biotechnology

Editor-in-Chief

ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

Phage Displayed Biomolecules As Preventive and Therapeutic Agents

Author(s): K. Manoutcharian, G. Gevorkian, A. Cano and J. C. Almagro

Volume 2, Issue 3, 2001

Page: [217 - 223] Pages: 7

DOI: 10.2174/1389201013378671

Price: $65

Abstract

Phage display is a powerful technology for selecting and engineering peptides and proteins expressed on the surface of filamentous bacteriophage. The advantages of phage display technology over other research tools and its great potential have been demonstrated by successful application of phage display in diverse fields of biomedical / clinical research. In this review we will describe some recent developments in phage display, including new expression vectors, display formats, bioselection strategies and applications in pharmaceutical biotechnology. We highlight some important applications of phage display to identify disease- and pathogen-specific biomolecules, making particular emphasis on development of phage display-derived preventive and therapeutic vaccines.

Keywords: phage display, phage immunogens


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