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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

The Multicomponent Reactions and their Libraries for Natural and Preparative Chemistry

Author(s): I. Ugi and S. Heck

Volume 4, Issue 1, 2001

Page: [1 - 34] Pages: 34

DOI: 10.2174/1386207013331291

Price: $65

Abstract

It was recently recognized that three different types of multi-component reactions (MCRs) exist. In preparative chemistry, the MCRs of type II form their products particularly efficiently. These reactions correspond to equilibria of educts and intermediate products, whose final products are formed practically irreversibly. In recent years, the four component reaction of the isocyanides (U-4CR) of type II and their unions with various reactions and MCRs have become an important industrial process for preparing products and their libraries. It has been demonstrated that all conceivable collections of U-4CR educts can be converted into the corresponding products. In the usual chemical reactions, only the substituents of the products can be varied, whereas the U-4CR and related reactions can also produce skeletally different types of products with diverse substituents. The preparative advantages of forming products by the one-pot MCRs and the great variety of the possible products are illustrated in this review.

Keywords: Multicomponent Reaction, preparative Chemistry, Tetrahedral part, deprotonable weak acid, imidoanhydrides, DEPT NMR, endothermic, Isocynide, Tandem Domino, polycycloadditions, Educts

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