Abstract
Numbers of biologically active compounds are glycosides. Sometimes, the glycosidic residue is crucial for their activity, in other cases glycosylation only improves pharmacokinetic parameters. Recent developments in molecular glycobiology brought better understanding to the aglycone vs. glycoside activities, and made possible to develop new, more active or more effective glycodrugs based on these findings - very illustrative recent example is the story of vancomycin. This paper deals with an array of glycosidic compounds currently used in medicine but also with biological activity of some glycosidic metabolites of the known drugs. It involves glycosides of vitamins, polyphenolic glycosides (flavonoids), alkaloid glycosides, glycosides in the group of antibiotics, glycopeptides, cardiac glycosides, steroid and terpenoid glycosides etc. The physiological role of the glycosyl and structure-activity relations (SAR) in the glycosidic moiety (-ies) are discussed.
Keywords: glycosides, glycosidic residue, glycosylation, vitamins, polyphenilic glycoside flavonoids, alkaloid glycisides, antibiotics, glycopeptides, cardiac glycosides, glycisidic antibiotics, aminoglycoside antibiotics
Current Medicinal Chemistry
Title: Glycosides in Medicine: “The Role of Glycosidic Residue in Biological Activity”
Volume: 8 Issue: 11
Author(s): Vladimir Kren and Ludmila Martinkova
Affiliation:
Keywords: glycosides, glycosidic residue, glycosylation, vitamins, polyphenilic glycoside flavonoids, alkaloid glycisides, antibiotics, glycopeptides, cardiac glycosides, glycisidic antibiotics, aminoglycoside antibiotics
Abstract: Numbers of biologically active compounds are glycosides. Sometimes, the glycosidic residue is crucial for their activity, in other cases glycosylation only improves pharmacokinetic parameters. Recent developments in molecular glycobiology brought better understanding to the aglycone vs. glycoside activities, and made possible to develop new, more active or more effective glycodrugs based on these findings - very illustrative recent example is the story of vancomycin. This paper deals with an array of glycosidic compounds currently used in medicine but also with biological activity of some glycosidic metabolites of the known drugs. It involves glycosides of vitamins, polyphenolic glycosides (flavonoids), alkaloid glycosides, glycosides in the group of antibiotics, glycopeptides, cardiac glycosides, steroid and terpenoid glycosides etc. The physiological role of the glycosyl and structure-activity relations (SAR) in the glycosidic moiety (-ies) are discussed.
Export Options
About this article
Cite this article as:
Kren Vladimir and Martinkova Ludmila, Glycosides in Medicine: “The Role of Glycosidic Residue in Biological Activity”, Current Medicinal Chemistry 2001; 8 (11) . https://dx.doi.org/10.2174/0929867013372193
DOI https://dx.doi.org/10.2174/0929867013372193 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
A Technological Update of Molecular Diagnostics for Infectious Diseases
Infectious Disorders - Drug Targets Physcion and Physcion 8-O-β-D-glucopyranoside: Natural Anthraquinones with Potential Anticancer Activities
Current Drug Targets Editorial [Hot topic: Medicinal Chemistry Strategies to Minimize hERG Channel Effects 23 May (Guest Editor:Mark T. Bilodeau)]
Current Topics in Medicinal Chemistry PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile
Current Pharmaceutical Design Monocyclic and Fused Azines and Azoles as Histamine H<sub>4</sub> Receptor Ligands
Current Medicinal Chemistry A Survey of Calpain Inhibitors
Current Medicinal Chemistry Synthesis and Anti-cancer Activities of Apigenin Derivatives
Medicinal Chemistry Corrosion Mechanism of AM50 Magnesium Alloy in Simulated Acid Rain
Recent Patents on Corrosion Science (Discontinued) Abelson Tyrosine-Protein Kinase 1 as Principal Target for Drug Discovery Against Leukemias. Role of the Current Computer-Aided Drug Design Methodologies
Current Topics in Medicinal Chemistry Therapies for Hepatitis C Infection: Targeting the Non-Structural Proteins of HCV
Current Medicinal Chemistry - Anti-Infective Agents Synthesis and Biological Evaluation of Benzophenone Derivatives as Potential HIV-1 Inhibitors
Medicinal Chemistry Nitric Dioxide as Biologically Important Radical and its Role in Molecular Mechanism of Pancreatic Inflammation
Current Pharmaceutical Analysis Microwave-Assisted Combinatorial Synthesis of 2-Alkyl-2-(NArylsulfonylindol- 3-yl)-3-N-Acyl-5-Aryl-1,3,4-Oxadiazolines as Anti-HIV- 1 Agents
Combinatorial Chemistry & High Throughput Screening How the Parts Organize in the Whole? A Top-Down View of Molecular Descriptors and Properties for QSAR and Drug Design
Mini-Reviews in Medicinal Chemistry Interaction Between DNA/histone Methyltransferases and their Inhibitors
Current Medicinal Chemistry Customizing G Protein-Coupled Receptor Models for Structure-Based Virtual Screening
Current Pharmaceutical Design Drug Delivery Systems and Strategies to Overcome the Barriers of Brain
Current Pharmaceutical Design Non-Peptidic GnRH Receptor Antagonists
Current Medicinal Chemistry A New Nuclear Material Safeguards Method Using Fractal Dimension
Current Analytical Chemistry Biology and Clinical Relevance of Mannose-Binding Lectin
Drug Design Reviews - Online (Discontinued)