Abstract
Short chain dehydrogenases/reductases (SDR) constitute a large protein family. The SDR family now includes more than 1,000 enzymes from humans, mammals, insects and bacteria, and exhibits a wide variety of substrate specificity for steroids, retinoids, prostaglandins, sugars, alcohols and other small molecules. These enzymes have a residue identity level of 15-30 perent. Much has been done in the last decade to understand the structure function relationships in the SDR enzymes. This review summarizes recent progress of structural and functional studies of the enzymes belonging to the SDR family (X ray crystal structure analyses and site directed mutagenesis studies). Based on these studies, the three dimensional structure, catalytic mechanism, coenzyme specificity, and substrate specificity of the SDR enzymes are discussed.
Keywords: SDR structure, Short chain dehydrogenase, Oxidoreductase, MDR enzymes, Monomeric enzymes, Single domain protein, Rossmann fold, C terminal residues, Coenzyme binding mode, pyrophosphate moiety, active site cleft, ser tyr lys triad, deprotonated phenolic group, coenzyme specificity, Substrate specificity, membrane spainnig domain
Current Organic Chemistry
Title: SDR Structure, Mechanism of Action, and Substrate Recognition
Volume: 5 Issue: 1
Author(s): Nobutada Tanaka, Takamasa Nonaka, Kazuo T. Nakamura and Akira Hara
Affiliation:
Keywords: SDR structure, Short chain dehydrogenase, Oxidoreductase, MDR enzymes, Monomeric enzymes, Single domain protein, Rossmann fold, C terminal residues, Coenzyme binding mode, pyrophosphate moiety, active site cleft, ser tyr lys triad, deprotonated phenolic group, coenzyme specificity, Substrate specificity, membrane spainnig domain
Abstract: Short chain dehydrogenases/reductases (SDR) constitute a large protein family. The SDR family now includes more than 1,000 enzymes from humans, mammals, insects and bacteria, and exhibits a wide variety of substrate specificity for steroids, retinoids, prostaglandins, sugars, alcohols and other small molecules. These enzymes have a residue identity level of 15-30 perent. Much has been done in the last decade to understand the structure function relationships in the SDR enzymes. This review summarizes recent progress of structural and functional studies of the enzymes belonging to the SDR family (X ray crystal structure analyses and site directed mutagenesis studies). Based on these studies, the three dimensional structure, catalytic mechanism, coenzyme specificity, and substrate specificity of the SDR enzymes are discussed.
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Cite this article as:
Tanaka Nobutada, Nonaka Takamasa, Nakamura T. Kazuo and Hara Akira, SDR Structure, Mechanism of Action, and Substrate Recognition, Current Organic Chemistry 2001; 5 (1) . https://dx.doi.org/10.2174/1385272013375751
DOI https://dx.doi.org/10.2174/1385272013375751 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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