Drug Metabolism Letters


Zhiyang Zhao
Alliance Pharma
Malvern, PA

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Open Access Articles

Prominence of Oxidative Stress in the Management of Anti-tuberculosis Drugs Related Hepatotoxicity open Access plus

Volume: 13   Issue: 2
Pp: 95-101
Preena John and Pravin P. Kale*

A Practical Perspective on the Evaluation of Small Molecule CNS Penetration in Drug Discovery open Access plus

Volume: 13   Issue: 2
Pp: 78-94
Liyue Huang*, Mary C. Wells and Zhiyang Zhao

Oral Bioavailability Enhancement of Amisulpride: Complexation and its Pharmacokinetics and Pharmacodynamics Evaluations open Access plus

Volume: 13   Issue: 2
Pp: 132-144
Prajapati Jagruti B.*, Sawant Krutika K. and Bhramanand Dubey

Assessment of Inhibition of Bovine Hepatic Cytochrome P450 by 43 Commercial Bovine Medicines Using a Combination of In Vitro Assays and Pharmacokinetic Data from the Literature open Access plus

Volume: 13   Issue: 2
Pp: 123-131
Steven X. Hu*, Chase A. Mazur and Kenneth L. Feenstra

The Effects of Special Patient Population Plasma on Pharmacokinetic Quantifications Using LC-MS/MS open Access plus

Volume: 13   Issue: 2
Pp: 111-122
Dongmei Zhou*, Lifang Sun, Mai Nguyen, Li- Tain Yeh and David M. Wilson

Imatinib Uptake into Cells is Not Mediated by Organic Cation Transporters OCT1, OCT2, or OCT3, But is Influenced by Extracellular pH open Access plus

Volume: 13   Issue: 2
Pp: 102-110
Jaurès Blanc Mettral, Nicolas Faller, Sandra Cruchon, Loïc Sottas, Thierry Buclin, Laurent Schild, Eva Choong, Aimable Nahimana and Laurent A. Decosterd*

Formation of a Toxic Quinoneimine Metabolite from Diclofenac: A Quantum Chemical Study open Access plus

Volume: 13   Issue: 1
Pp: 64-76
Muthusamy Ramesh* and Prasad V. Bharatam

Comparison of Rat and Human Pulmonary Metabolism Using Precision-cut Lung Slices (PCLS) open Access plus

Volume: 13   Issue: 1
Pp: 53-63
Yildiz Yilmaz*, Gareth Williams, Markus Walles, Nenad Manevski, Stephan Krähenbühl and Gian Camenisch

“Branched Tail” Oxyquinoline Inhibitors of HIF Prolyl Hydroxylase: Early Evaluation of Toxicity and Metabolism Using Liver-on-a-chip open Access plus

Volume: 13   Issue: 1
Pp: 45-52
Andrey A. Poloznikov*, Sergey V. Nikulin, Arpenik A. Zakhariants, Anna Y. Khristichenko, Dmitry M. Hushpulian, Ildar N. Gazizov, Vladimir I. Tishkov and Irina G. Gazaryan

Unequal Absorption of Radiolabeled and Nonradiolabeled Drug from the Oral Dose Leads to Incorrect Estimates of Drug Absorption and Circulating Metabolites in a Mass Balance Study open Access plus

Volume: 13   Issue: 1
Pp: 37-44
Ryan H. Takahashi*, Jae H. Chang, Jodie Pang, Xiaorong Liang and Shuguang Ma

Use of Cocktail Probe Drugs for Indexing Cytochrome P450 Enzymes in Clinical Pharmacology Studies – Review of Case Studies open Access plus

Volume: 13   Issue: 1
Pp: 3-18
Poonam Giri, Harilal Patel and Nuggehally R. Srinivas*

Transport of Bupropion and its Metabolites by the Model CHO and HEK293 Cell Lines open Access plus

Volume: 13   Issue: 1
Pp: 25-36
Lyrialle W. Han, Chunying Gao, Yuchen Zhang, Joanne Wang and Qingcheng Mao*

Effect of Aqueous Extract of Azadirachta indica Leaves on Pharmacokineics and Pharmacodynamics of Glipizide open Access plus

Volume: 13   Issue: 1
Pp: 19-24
Sugandha Chaudhari*, Shitalkumar Zambad and Mohammed Ali

Using LC Retention Times in Organic Structure Determination: Drug Metabolite Identification open Access plus

Volume: 12   Issue: 2
Pp: 93-100
William L. Fitch*, Cyrus Khojasteh, Ignacio Aliagas and Kevin Johnson

Quantitative Proteomics Reveals Changes in Transporter Protein Abundance in Liver, Kidney and Brain of Mice by Pregnancy open Access plus

Volume: 12   Issue: 2
Pp: 145-152
Michael Z. Liao, Chunying Gao, Deepak Kumar Bhatt, Bhagwat Prasad and Qingcheng Mao*

Genistein Affects Expression of Cytochrome P450 (CYP450) Genes in Hepatocellular Carcinoma (HEPG2/C3A) Cell Line open Access plus

Volume: 12   Issue: 2
Pp: 138-144
Sandra R. Lepri, Daniele Sartori, Simone C. Semprebon*, Adrivanio Baranoski, Giuliana C. Coatti and Mario S. Mantovani

A Novel In vitro Experimental System for the Evaluation of Enteric Drug Metabolism: Cofactor-Supplemented Permeabilized Cryopreserved Human Enterocytes (MetMax™ Cryopreserved Human Enterocytes) open Access plus

Volume: 12   Issue: 2
Pp: 132-137
Albert P. Li*, Kirsten Amaral and Ming-Chih D. Ho

Hepatic Flavin-containing Monooxygenase and Aldehyde Oxidase Activities in Male Domestic Pigs at Different Ages open Access plus

Volume: 12   Issue: 2
Pp: 125-131
Steven X. Hu*

In Vitro Drug-Drug Interaction Potential of Sulfoxide and/or Sulfone Metabolites of Albendazole, Triclabendazole , Aldicarb, Methiocarb, Montelukast and Ziprasidone open Access plus

Volume: 12   Issue: 2
Pp: 101-116
Poonam Giri, Lakshmikant Gupta, Sneha Naidu, Vipul Joshi, Nirmal Patel, Shyamkumar Giri and Nuggehally R. Srinivas*

Cytochrome P450 3A4 Induction: Lumacaftor versus Ivacaftor Potentially Resulting in Significantly Reduced Plasma Concentration of Ivacaftor open Access plus

Volume: 12   Issue: 1
Pp: 71-74
Elena K. Schneider*

In vitro Drug Metabolism Investigation of 7-Ethoxycoumarin in Human, Monkey, Dog and Rat Hepatocytes by High Resolution LC-MS/MS open Access plus

Volume: 12   Issue: 1
Pp: 33-53
Wan-Yong Feng*, Jenny Wen and Kathe Stauber

Transactivation Assays that Identify Indirect and Direct Activators of Human Pregnane X Receptor (PXR, NR1I2) and Constitutive Androstane Receptor (CAR, NR1I3) open Access plus

Volume: 11   Issue: 2
Pp: 128-137
Marija Pinne*, Elsa Ponce and Judy L. Raucy

The Metabolism of Methazolamide in Immortalized Human Keratinocytes, HaCaT Cells open Access plus

Volume: 10   Issue: 4
Pp: 295-305
Tetsuo Sasabe*, Shinichiro Maeda, Kenichi Kishida, Mariko Yamano, Yoshihiro Miwa and Toshihiro Sugiyama

Rate-Determining and Rate-Limiting Steps in the Clearance and Excretion of a Potent and Selective p21-Activated Kinase Inhibitor: A Case Study of Rapid Hepatic Uptake and Slow Elimination in Rat open Access plus

Volume: 10   Issue: 2
Pp: 91-100
Peter W. Fan, Jacob Z. Chen, M. Allan Jaochico, Hank La, Ning Liu, Teresa Mulder, Robert T. Cass, Matthew Durk, Kirsten Messick, Nicole Valle, Shannon Liu, Wendy Lee, James J. Crawford, Joachim Rudolf, Lesley J. Murray, S. Cyrus Khojasteh and Matthew Wright

Efficiency in Drug Discovery: Liver S9 Fraction Assay As a Screen for Metabolic Stability open Access plus

Volume: 10   Issue: 2
Pp: 83-90
Samantha J. Richardson, April Bai, Ashutosh A. Kulkarni and Mehran F. Moghaddam

Commentary: A Myriad Aberrations on Information of Ontogeny of Drug Metabolizing Enzymes in the Pediatric Population: An Obstacle for Personalizing Drug Therapy in the Pediatric Population open Access plus

Volume: 10   Issue: 2
Pp: 72-74
Chakradhara Rao S. Uppugunduri and Marc Ansari

Formation of A Novel Purine Metabolite through CYP3A4 Bioactivation and Glutathione Conjugation open Access plus

Volume: 10   Issue: 2
Pp: 144-150
Julius L. Apuy, Cathie Xiang, Sarah Franc, Sayee G. Hegde, Robert Hubbard, Jingjing Zhao and Mehran F. Moghaddam

Impact of Cytochrome P450 2C19*2 and *3 on Clopidogrel Loading Dose in Saudi Patients with Acute Coronary Syndrome open Access plus

Volume: 10   Issue: 1
Pp: 65-70
Hassan Khalaf, Ahmad AbdulRahman Al Meman and Seemab Rasool

Influence of ABCB1 Gene Polymorphisms and P-Glycoprotein Activity on Cyclosporine Pharmacokinetics in Peripheral Blood Mononuclear Cells in Healthy Volunteers open Access plus

Volume: 2   Issue: 2
Pp: 76-82
Nicolas Ansermot, Michela Rebsamen, Jocelyne Chabert, Marc Fathi, Marianne Gex-Fabry, Youssef Daali, Marie Besson, Michel Rossier, Serge Rudaz, Denis Hochstrasser, Pierre Dayer and Jules Desmeules

Long Term Treatment with Tetradecylthioacetic Acid Improves the Antioxidant Status in Obese Zucker (fa/fa) Rats open Access plus

Volume: 2   Issue: 2
Pp: 138-145
Hege Wergedahl, Kjetil Berge, Pavol Bohov, Karl-Johan Tronstad, Lise Madsen and Rolf K. Berge