Drug Metabolism Letters

Carbon-Carbon Bond Cleavage Catalyzed by Human Cytochrome P450 Enzymes: α-Ketol as the Key Intermediate Metabolite in Sequential Metabolism of Olanexidine

Volume: 14   Issue: 1
Pp: 41-53
Yiding Hu*, Yi Xiao, Zhesui Rao, Vasant Kumar, Hanlan Liu and Chuang Lu
DOI: 10.2174/1872312813666191125095818

Pharmacokinetics of Darolutamide in Mouse - Assessment of the Disposition of the Diastereomers, Key Active Metabolite and Interconversion Phenomenon: Implications to Cancer Patients

Volume: 14   Issue: 1
Pp: 54-65
Neeraj K. Saini, Bhavesh B. Gabani, Umesh Todmal, Suresh P. Sulochana, Vinay Kiran, Mohd. Zainuddin, Narayanan Balaji, Sai B. Polina, Nuggehally R. Srinivas and Ramesh Mullangi*
DOI: 10.2174/1872312814666200521091236

Major CYP450 polymorphism Among Saudi Patients

Volume: 14   Issue: 1
Pp: 17-24
Ahmad A. Almeman*
DOI: 10.2174/1872312814666200722122232

A Short Exploration of Selected Sensitive CYP3A4 Substrates (Probe Drug)

Volume: 14   Issue: 1
Pp: 2-4
Sarvesh Sabarathinam and Thangavel M. Vijayakumar*
DOI: 10.2174/1872312814666200811110024

Amorphous Solid Dispersion Based Oral Disintegrating Film of Ezetimibe: Development and Evaluation

Volume: 14   Issue: 1
Pp: 66-79
Preethi Sudheer*, Sangam Shrestha and Kavitha A. Narayana
DOI: 10.2174/1872312814666200901182517

Hemodynamic Assessment and in vivo Catabolism of Adenosine 5’-triphosphate in Doxorubicin or Isoproterenol-induced Cardiovascular Toxicity

Volume: 14   Issue: 1
Pp: 80-88
Pollen K. Yeung*, Sheyda Mohammadizadeh, Fatemeh Akhoundi, Kelsey Mann, Remigius U. Agu and Thomas Pulinilkunnil
DOI: 10.2174/1872312814666201022103802

Pharmacokinetics of Darolutamide, its Diastereomers and Active Metabolite in the Mouse: Response to Saini NK et al. (2020) open access plus

Volume: 14   Issue: 1
Pp: 9-16
Pirjo Nykänen, Timo Korjamo, Hille Gieschen, Christian Zurth and Mikko Koskinen*
DOI: 10.2174/1872312814666201112121129

Assessment of Herb-Drug Interactions Based on the Pharmacokinetic Changes of Probe Drug, Midazolam

Volume: 14   Issue: 1
Pp: 5-8
Sarvesh Sabarathinam* and Thangavel M. Vijayakumar*
DOI: 10.2174/1872312814666201112122110

Recent Progress in Prediction Systems for Drug-induced Liver Injury Using In Vitro Cell Culture

Volume: 14   Issue: 1
Pp: 25-40
Shogo Ozawa*, Toshitaka Miura, Jun Terashima, Wataru Habano and Seiichi Ishida
DOI: 10.2174/1872312814666201202112610

The Effect of Pomegranate Juice on the Expression of Some Murine UDP-Glucuronosyltransferases Genes

Volume: 14   Issue: 1
Pp: 89-93
Yacoub M. Irshaid*, Ruba Alani, Razan Al-Rawashdeh, Tuqa Al-Ghazawi, Hiba Hijazi, Dana Amara, Amena Hammad, Zaineh M. Shahrure and Mohammad Al-Shhab
DOI: 10.2174/1872312814999201211203314

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Volume: 14   Issue: 1
Pp: 1-1
Suresh Balani
DOI: 10.2174/187231281401210415112543

Assessment of prescribability and switchability by using multiple bioequivalence assessment approaches

Volume: 14   Issue:
Pp: 1-1
Francis Micheal*, Mohanlal Sayana, Rajendra Prasad and Balamurali Musuvathi Motiala
DOI: 10.2174/1872312814666210319124659

The role of aldehyde oxidase in the metabolic clearance of substituted benzothiazoles

Volume: 14   Issue:
Pp: 1-1
Yohannes Teffera*, Jingzhou Liu, Paul Krolikowski and Zhiyang Zhao
DOI: 10.2174/1872312814666210405101419

Imatinib Uptake into Cells is Not Mediated by Organic Cation Transporters OCT1, OCT2, or OCT3, But is Influenced by Extracellular pH open access plus

Volume: 13   Issue: 2
Pp: 102-110
Jaurès Blanc Mettral, Nicolas Faller, Sandra Cruchon, Loïc Sottas, Thierry Buclin, Laurent Schild, Eva Choong, Aimable Nahimana and Laurent A. Decosterd*
DOI: 10.2174/1872312813666190207150207

A Practical Perspective on the Evaluation of Small Molecule CNS Penetration in Drug Discovery open access plus

Volume: 13   Issue: 2
Pp: 78-94
Liyue Huang*, Mary C. Wells and Zhiyang Zhao
DOI: 10.2174/1872312813666190311125652

Prominence of Oxidative Stress in the Management of Anti-tuberculosis Drugs Related Hepatotoxicity open access plus

Volume: 13   Issue: 2
Pp: 95-101
Preena John and Pravin P. Kale*
DOI: 10.2174/1872312813666190716155930

The Effects of Special Patient Population Plasma on Pharmacokinetic Quantifications Using LC-MS/MS open access plus

Volume: 13   Issue: 2
Pp: 111-122
Dongmei Zhou*, Lifang Sun, Mai Nguyen, Li- Tain Yeh and David M. Wilson
DOI: 10.2174/1872312813666191015162634

Oral Bioavailability Enhancement of Amisulpride: Complexation and its Pharmacokinetics and Pharmacodynamics Evaluations open access plus

Volume: 13   Issue: 2
Pp: 132-144
Prajapati Jagruti B.*, Sawant Krutika K. and Bhramanand Dubey
DOI: 10.2174/1872312813666191018152226

Assessment of Inhibition of Bovine Hepatic Cytochrome P450 by 43 Commercial Bovine Medicines Using a Combination of In Vitro Assays and Pharmacokinetic Data from the Literature open access plus

Volume: 13   Issue: 2
Pp: 123-131
Steven X. Hu*, Chase A. Mazur and Kenneth L. Feenstra
DOI: 10.2174/1872312813666191120094649

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Volume: 13   Issue: 2
Pp: 77-77
Bo Wen
DOI: 10.2174/187231281302200115143055

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Volume: 13   Issue: 2
Pp: 145-145

DOI: 10.2174/187231281302200115152301

Formation of a Toxic Quinoneimine Metabolite from Diclofenac: A Quantum Chemical Study open access plus

Volume: 13   Issue: 1
Pp: 64-76
Muthusamy Ramesh* and Prasad V. Bharatam
DOI: 10.2174/1872312812666180913120736

Comparison of Rat and Human Pulmonary Metabolism Using Precision-cut Lung Slices (PCLS) open access plus

Volume: 13   Issue: 1
Pp: 53-63
Yildiz Yilmaz*, Gareth Williams, Markus Walles, Nenad Manevski, Stephan Krähenbühl and Gian Camenisch
DOI: 10.2174/1872312812666181022114622

Effect of Aqueous Extract of Azadirachta indica Leaves on Pharmacokineics and Pharmacodynamics of Glipizide open access plus

Volume: 13   Issue: 1
Pp: 19-24
Sugandha Chaudhari*, Shitalkumar Zambad and Mohammed Ali
DOI: 10.2174/1872312812666181106115247

Use of Cocktail Probe Drugs for Indexing Cytochrome P450 Enzymes in Clinical Pharmacology Studies – Review of Case Studies open access plus

Volume: 13   Issue: 1
Pp: 3-18
Poonam Giri, Harilal Patel and Nuggehally R. Srinivas*
DOI: 10.2174/1872312812666181119154734

“Branched Tail” Oxyquinoline Inhibitors of HIF Prolyl Hydroxylase: Early Evaluation of Toxicity and Metabolism Using Liver-on-a-chip open access plus

Volume: 13   Issue: 1
Pp: 45-52
Andrey A. Poloznikov*, Sergey V. Nikulin, Arpenik A. Zakhariants, Anna Y. Khristichenko, Dmitry M. Hushpulian, Ildar N. Gazizov, Vladimir I. Tishkov and Irina G. Gazaryan
DOI: 10.2174/1872312813666181129100950

Transport of Bupropion and its Metabolites by the Model CHO and HEK293 Cell Lines open access plus

Volume: 13   Issue: 1
Pp: 25-36
Lyrialle W. Han, Chunying Gao, Yuchen Zhang, Joanne Wang and Qingcheng Mao*
DOI: 10.2174/1872312813666181129101507

Unequal Absorption of Radiolabeled and Nonradiolabeled Drug from the Oral Dose Leads to Incorrect Estimates of Drug Absorption and Circulating Metabolites in a Mass Balance Study open access plus

Volume: 13   Issue: 1
Pp: 37-44
Ryan H. Takahashi*, Jae H. Chang, Jodie Pang, Xiaorong Liang and Shuguang Ma
DOI: 10.2174/1872312813666181129162237

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Volume: 13   Issue: 1
Pp: 1-1
Qing-Hua Wu
DOI: 10.2174/187231281301190430103648

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Volume: 13   Issue: 1
Pp: 2-2
Suresh Balani
DOI: 10.2174/187231281301190430103757

New Perspectives on Acyl Glucuronide Risk Assessment in Drug Discovery: Investigation of In vitro Stability, In situ Reactivity, and Bioactivation

Volume: 12   Issue: 2
Pp: 84-92
Mithat Gunduz*, Upendra A. Argikar, Amanda L. Cirello and Jennifer L. Dumouchel
DOI: 10.2174/1872312812666180611113656

Effects of Tobacco Nicotine-Derived Nitrosamine Ketone (NNK) Exposures on Brain Alcohol Metabolizing Enzyme Activities

Volume: 12   Issue: 2
Pp: 117-124
Emine B. Yalcin, Ming Tong, Gina Gallucci and Suzanne M. de la Monte*
DOI: 10.2174/1872312812666180611115418

Quantitative Proteomics Reveals Changes in Transporter Protein Abundance in Liver, Kidney and Brain of Mice by Pregnancy open access plus

Volume: 12   Issue: 2
Pp: 145-152
Michael Z. Liao, Chunying Gao, Deepak Kumar Bhatt, Bhagwat Prasad and Qingcheng Mao*
DOI: 10.2174/1872312812666180625122810

Genistein Affects Expression of Cytochrome P450 (CYP450) Genes in Hepatocellular Carcinoma (HEPG2/C3A) Cell Line open access plus

Volume: 12   Issue: 2
Pp: 138-144
Sandra R. Lepri, Daniele Sartori, Simone C. Semprebon*, Adrivanio Baranoski, Giuliana C. Coatti and Mario S. Mantovani
DOI: 10.2174/1872312812666180709150440

Alam K et al. (2018) Drug Metabolism Letters; 12, 24-32. promotion: free to download

Volume: 12   Issue: 2
Pp: 153-153
Tristan M. Sissung, Cindy Chau, Douglas K. Price and William D. Figg*
DOI: 10.2174/1872312812999180724145725

Using LC Retention Times in Organic Structure Determination: Drug Metabolite Identification open access plus

Volume: 12   Issue: 2
Pp: 93-100
William L. Fitch*, Cyrus Khojasteh, Ignacio Aliagas and Kevin Johnson
DOI: 10.2174/1872312812666180802093347

In Vitro Drug-Drug Interaction Potential of Sulfoxide and/or Sulfone Metabolites of Albendazole, Triclabendazole , Aldicarb, Methiocarb, Montelukast and Ziprasidone open access plus

Volume: 12   Issue: 2
Pp: 101-116
Poonam Giri, Lakshmikant Gupta, Sneha Naidu, Vipul Joshi, Nirmal Patel, Shyamkumar Giri and Nuggehally R. Srinivas*
DOI: 10.2174/1872312812666180816164626

A Novel In vitro Experimental System for the Evaluation of Enteric Drug Metabolism: Cofactor-Supplemented Permeabilized Cryopreserved Human Enterocytes (MetMax™ Cryopreserved Human Enterocytes) open access plus

Volume: 12   Issue: 2
Pp: 132-137
Albert P. Li*, Kirsten Amaral and Ming-Chih D. Ho
DOI: 10.2174/1872312812666180820142141

Hepatic Flavin-containing Monooxygenase and Aldehyde Oxidase Activities in Male Domestic Pigs at Different Ages open access plus

Volume: 12   Issue: 2
Pp: 125-131
Steven X. Hu*
DOI: 10.2174/1872312812666180913145334

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Volume: 12   Issue: 2
Pp: 83-83
Kexin Liu
DOI: 10.2174/187231281202181122155642

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Volume: 12   Issue: 2
Pp: 154-154

DOI: 10.2174/187231281202181122155844

Utility of Pooled Cryopreserved Human Enterocytes as an In vitro Model for Assessing Intestinal Clearance and Drug-Drug Interactions

Volume: 12   Issue: 1
Pp: 3-13
Susan Wong, Utkarsh Doshi, Peter Vuong, Ning Liu, Suzanne Tay, Hoa Le, Mika Kosaka, Jane R. Kenny, Albert P. Li and Zhengyin Yan*
DOI: 10.2174/1872312812666171213114422

Cytochrome P450 1A2 Messenger RNA is a More Reliable Marker than Cytochrome P450 1A2 Activity, Phenacetin O-Deethylation, for Assessment of Induction Potential of Drug-Metabolizing Enzymes Using HepaRG Cells

Volume: 12   Issue: 1
Pp: 14-23
Akira Ogasawara*, Nozomu Kato, Nao Torimoto, Fumika Aohara, Rikiya Ohashi, Yasuhiro Yamada and Hideki Taniguchi
DOI: 10.2174/1872312812666180119114013

LC-MS/MS Identification and Structural Characterization of Main Biodegradation Products of Nitroproston - A Novel Prostaglandin-based Pharmaceutical Compound

Volume: 12   Issue: 1
Pp: 54-61
Natalia V. Mesonzhnik*, Natalia E. Moskaleva, Ksenia M. Shestakova, Ksenya O. Kurynina, Pavel A. Baranov, Natalia M. Gretskaya, Igor V. Serkov, Igor I. Lyubimov, Vladimir V. Bezuglov and Svetlana A. Appolonova
DOI: 10.2174/1872312812666180309160927

Evaluation of Herb-Drug Interaction of Synacinn™ and Individual Biomarker through Cytochrome 450 Inhibition Assay

Volume: 12   Issue: 1
Pp: 62-67
Nur Syukriah Ab Rahman, Fadzilah Adibah Abd Majid*, Mohd Effendy Abd Wahid, Ain Nabihah Zainudin, Siti Nurazwa Zainol, Hassan Fahmi Ismail, Tet Soon Wong, Nirbhay Kumar Tiwari, Sanjeev Giri and Vijaya Bhargava
DOI: 10.2174/1872312812666180314112457

Characterization of Liver- and Cancer-type-Organic Anion Transporting Polypeptide (OATP) 1B3 Messenger RNA Expression in Normal and Cancerous Human Tissues

Volume: 12   Issue: 1
Pp: 24-32
Khondoker Alam, Taleah Farasyn, Kai Ding and Wei Yue*
DOI: 10.2174/1872312812666180326110146

Cytochrome P450 3A4 Induction: Lumacaftor versus Ivacaftor Potentially Resulting in Significantly Reduced Plasma Concentration of Ivacaftor open access plus

Volume: 12   Issue: 1
Pp: 71-74
Elena K. Schneider*
DOI: 10.2174/1872312812666180328105259

Evaluation of the Effect of Uremic Serum on Hepatic Reductase Functional Expression

Volume: 12   Issue: 1
Pp: 75-81
Osama Y. Alshogran*, Esra`a F. Al-Obaidi, Belal A. Al-Husein and Ashraf O. Oweis
DOI: 10.2174/1872312812666180416154436

In vitro Drug Metabolism Investigation of 7-Ethoxycoumarin in Human, Monkey, Dog and Rat Hepatocytes by High Resolution LC-MS/MS open access plus

Volume: 12   Issue: 1
Pp: 33-53
Wan-Yong Feng*, Jenny Wen and Kathe Stauber
DOI: 10.2174/1872312812666180418142056

Effect of CYP2D6 Poor Metabolizer Phenotype on Stereoselective Nebivolol Pharmacokinetics

Volume: 12   Issue: 1
Pp: 68-70
Carolina P. Vieira, Daniel V. Neves, Eduardo B. Coelho and Vera Lucia Lanchote*
DOI: 10.2174/1872312812666180420104945

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Volume: 12   Issue: 1
Pp: 1-1
Michael Sinz
DOI: 10.2174/187231281201180828160634

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Volume: 12   Issue: 1
Pp: 2-2
Suresh Balani
DOI: 10.2174/187231281201180828160801

A Pharmacokinetic-Pharmacodynamic Model of Tamoxifen and Endoxifen to Predict Their Distribution and Effects on Inhibition of Tumor Growth

Volume: 11   Issue: 2
Pp: 93-101
Shengyue Yuan, Qingrong Sun, Yao Chen and Jun Liao*
DOI: 10.2174/1872312811666170815160751

Investigation of Ocular Bioactivation Potential and the Role of Cytochrome P450 2D Enzymes in Rat

Volume: 11   Issue: 2
Pp: 102-110
Jennifer L. Dumouchel*, Upendra A. Argikar, Jaimie Spear, Ann Brown, Christine E. Dunne, Valerie M. Kramlinger, Amanda L. Cirello and Mithat Gunduz
DOI: 10.2174/1872312811666170911122919

The Effects of Drug Metabolizing Enzyme Inhibitors on Hepatic Efflux and Uptake Transporters

Volume: 11   Issue: 2
Pp: 111-118
Jonathan Cheong, Jason S. Halladay, Emile Plise, Jasleen K. Sodhi and Laurent Salphati*
DOI: 10.2174/1872312811666171010101248

Genotoxicity of 4-(piperazin-1-yl)-8-(trifluoromethyl)pyrido[2,3-e][1,2,4] triazolo[4,3-a]pyrazine, a Potent H4 Receptor Antagonist for the Treatment of Allergy: Evidence of Glyoxal Intermediate Involvement

Volume: 11   Issue: 2
Pp: 144-148
Mithat Gunduz*, Amanda L. Cirello, Peter Klimko, Jennifer L. Dumouchel and Upendra A. Argikar
DOI: 10.2174/1872312811666171106151730

Analysis of Elevated Levels of Nandrolone Decanoate Induced Cytochrome- P450 Alterations in Mice

Volume: 11   Issue: 2
Pp: 86-92
Parmita Chowdhury* and Rita Mahanta
DOI: 10.2174/1872312811666171114145535

Therapeutic Potentials and Cytochrome P450-Mediated Interactions Involving Herbal Products Indicated for Diabetes Mellitus

Volume: 11   Issue: 2
Pp: 74-85
Cyprian O. Onyeji*, Sharon I. Igbinoba and Gbola Olayiwola
DOI: 10.2174/1872312811666171121104431

Selective Suppression of CYP3A4 mRNA and Enzyme Activity by Epidermal Growth Factor in Plated Human Hepatocytes

Volume: 11   Issue: 2
Pp: 119-127
J. George Zhang*, Duan Wang, Thuy Ho, Robert J. Clark and David M. Stresser
DOI: 10.2174/1872312811666171128141105

Transactivation Assays that Identify Indirect and Direct Activators of Human Pregnane X Receptor (PXR, NR1I2) and Constitutive Androstane Receptor (CAR, NR1I3) open access plus

Volume: 11   Issue: 2
Pp: 128-137
Marija Pinne*, Elsa Ponce and Judy L. Raucy
DOI: 10.2174/1872312812666171207113639

Evaluation of Farnesoid X Receptor Target Gene Induction in Human Hepatocytes: Amino Acid Conjugation

Volume: 11   Issue: 2
Pp: 138-143
Jean Simmermacher* and Michael Sinz
DOI: 10.2174/1872312812666171227213946

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Volume: 11   Issue: 2
Pp: 73-73
W.G. Humphreys
DOI: 10.2174/187231281102180208095812

Obesity and Inflammation and Altered Clopidogrel Pharmacokinetics and Pharmacodynamics

Volume: 11   Issue: 1
Pp: 3-13
Nicholas B. Norgard* and Scott V. Monte
DOI: 10.2174/1872312811666170301110349

Inhibitory Effect of Fruit Juices on the Doxorubicin Metabolizing Activity of Carbonyl Reductase 1

Volume: 11   Issue: 1
Pp: 48-52
Takeshi Miura*, Katsutoshi Nagai, Shingo Kaneshiro, Ayako Taketomi, Toshikatsu Nakabayashi, Hiroki Konishi, Toru Nishinaka and Tomoyuki Terada
DOI: 10.2174/1872312811666170309153025

Gender Difference of Hepatic and Intestinal CYP3A4 in CYP3AHumanized Mice Generated by a Human Chromosome-engineering Technique

Volume: 11   Issue: 1
Pp: 60-67
Kaoru Kobayashi*, Chihiro Abe, Mika Endo, Yasuhiro Kazuki, Mitsuo Oshimura and Kan Chiba
DOI: 10.2174/1872312811666170404153804

Metabolic Profile of Flunitrazepam: Clinical and Forensic Toxicological Aspects

Volume: 11   Issue: 1
Pp: 14-20
Ricardo Jorge Dinis-Oliveira*
DOI: 10.2174/1872312811666170407164216

Effects of Fenofibrate on the Expression of Small Heterodimer Partner (SHP) and Cytochrome P450 (CYP) 2D6

Volume: 11   Issue: 1
Pp: 68-72
Rebecca Kent and Hyunyoung Jeong*
DOI: 10.2174/1872312811666170407164631

The Role of Placental Carbonyl Reducing Enzymes in Biotransformation of Bupropion and 4-methylnitrosamino-1-(3-pyridyl)-1-butanone

Volume: 11   Issue: 1
Pp: 29-34
Valentina M. Fokina, Svetlana L. Patrikeeva, Cheryl Oncken, Gary D.V. Hankins, Mahmoud S. Ahmed and Tatiana Nanovskaya*
DOI: 10.2174/1872312811666170607095202

Potential Minor Haplotypes of CYP2D6 in the Japanese Population

Volume: 11   Issue: 1
Pp: 53-59
Masatoshi Masuda*, Tsutomu Fujiwara, Masayuki Matsunaga and Takehisa Matsumaru
DOI: 10.2174/1872312811666170613080221

Mixed Matrix Method Provides A Reliable Metabolite Exposure Comparison for Assessment of Metabolites in Safety Testing (MIST)

Volume: 11   Issue: 1
Pp: 21-28
Ryan H. Takahashi, Cyrus Khojasteh, Matthew Wright, Cornelis E.C.A. Hop and Shuguang Ma*
DOI: 10.2174/1872312811666170710193229

Quantification of Sulfotransferases 1A1 and 1A3/4 in Tissue Fractions and Cell Lines by Multiple Reaction Monitoring Mass Spectrometry

Volume: 11   Issue: 1
Pp: 35-47
Sho Yoshitake, Melissa McKay-Daily, Masaki Tanaka and Zeqi Huang*
DOI: 10.2174/1872312811666170731170153

Genipin Inhibits the Induction of Inducible Nitric Oxide Synthase Through the Inhibition of NF-κB Activation in Rat Hepatocytes

Volume: 10   Issue: 4
Pp: 254-263
Richi Nakatake, Takumi Tsuda, Takashi Matsuura, Hirokazu Miki, Hidehiko Hishikawa, Hideyuki Matsushima, Morihiko Ishizaki, Kosuke Matsui, Masaki Kaibori, Mikio Nishizawa, Tadayoshi Okumura* and Masanori Kon
DOI: 10.2174/1872312810666161020164658

Cytochrome P450 2A6 Phenotyping Using Dietary Caffeine Salivary Metabolite Ratios and Genotyping Using Blood on Storage Cards in Non-smoking Japanese Volunteers

Volume: 10   Issue: 4
Pp: 240-243
Norie Murayama, Makiko Shimizu, Kenta Kobayashi, Izumi Kishimoto and Hiroshi Yamazaki*
DOI: 10.2174/1872312810666161114144008

Strong Induction of Cytochrome P450 1A/3A, But not P450 2B, in Cultured Hepatocytes from Common Marmosets and Cynomolgus Monkeys by Typical Human P450 Inducing Agents

Volume: 10   Issue: 4
Pp: 244-253
Shotaro Uehara, Yasuhiro Uno, Takako Suzuki, Takashi Inoue, Masahiro Utoh, Erika Sasaki and Hiroshi Yamazaki*
DOI: 10.2174/1872312810666161114144412

A Novel Liquid Chromatography Tandem Mass Spectrometry Method for the Estimation of Bilirubin Glucuronides and its Application to In Vitro Enzyme Assays

Volume: 10   Issue: 4
Pp: 264-269
Siva P. Putluru*, Murali K. Matta, Deepak Ahire, Murali Subramanian, Michael Sinz and Sandhya Mandlekar
DOI: 10.2174/1872312810666161124143522

Ortho-Methylarylamines as Time-Dependent Inhibitors of Cytochrome P450 1A1 Enzyme

Volume: 10   Issue: 4
Pp: 270-277
Jayalakshmi Sridhar*, Jiawang Liu*, Rajesh Komati*, Richard Schroeder*, Quan Jiang*, Phan Tram*, Kevin Riley* and Maryam Foroozesh*
DOI: 10.2174/1872312810666161220155226

Variability of Zaleplon 5-Oxidase Activity in Mice and Humans, and Inhibition by Raloxifene

Volume: 10   Issue: 4
Pp: 278-285
Chiaki Tanoue, Kazumi Sugihara, Yoshitaka Tayama, Naoto Uramaru, Yoko Watanabe, Shigeru Ohta and Shigeyuki Kitamura*
DOI: 10.2174/1872312810666161227145358

Quantification of Etodolac in Human Plasma for Pharmacokinetics and Bioequivalence Studies in 27 Korean Subjects

Volume: 10   Issue: 4
Pp: 286-294
Il-Dong Song, Ju-Seop Kang*, Hyun-Jin Kim, Se-Mi Kim, Dong-Xu Zhao, Shin-Hee Kim, Min-Young Chun and Kyu-Hyun Lee
DOI: 10.2174/1872312811666170116151004

Pharmacokinetics, Metabolism and Disposition of [14C]XQ-1H After Intravenous Administration to Male Rats

Volume: 10   Issue: 4
Pp: 228-239
Yinlin Qin, Tao Chen, Qiu Jin, Kai Guo*, Hao Feng, Dennis Heller and Zhe-ming Gu
DOI: 10.2174/1872312811666170118162931

The Metabolism of Methazolamide in Immortalized Human Keratinocytes, HaCaT Cells open access plus

Volume: 10   Issue: 4
Pp: 295-305
Tetsuo Sasabe*, Shinichiro Maeda, Kenichi Kishida, Mariko Yamano, Yoshihiro Miwa and Toshihiro Sugiyama
DOI: 10.2174/1872312811666170127160931

Effect of Cardiovascular Injury on Catabolism of Adenosine and Adenosine 5-‘Triphosphate in Systemic Blood in a Freely Moving Rat Model In Vivo promotion: free to download

Volume: 10   Issue: 3
Pp: 219-226
Pollen K. Yeung, Shyam S. Kolathuru and Remigius U. Agu
DOI: 10.2174/1872312810666160607013859

An Investigation of Sodium Fusidate and Recombinant Cytochrome P450 Enzymes Inhibition In-Vitro promotion: free to download

Volume: 10   Issue: 3
Pp: 180-186
John Mishriky, Jacqueline Balassone, Zenah Bashour, Simranjit Kaur, Vini Raman, Robel Getachew, Narin Osman, Daniel Guidone, Vincent Chan and Peter J. Little
DOI: 10.2174/1872312810666160607015045

Inhibition of Procarcinogen Activating Enzyme CYP1A2 Activity and Free Radical Formation by Caffeic Acid and its Amide Analogues promotion: free to download

Volume: 10   Issue: 3
Pp: 187-194
Paitoon Narongchai, Kanokporn Niwatananun, Siripun Narongchai, Winthana Kusirisin and Churdsak Jaikang
DOI: 10.2174/1872312810666160608123113

Identification and Characterization of the Human Cytosolic Sulfotransferases Mediating the Sulfation of Clioquinol and Iodoquinol promotion: free to download

Volume: 10   Issue: 3
Pp: 200-205
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The Uremic Toxin Indoxyl-3-Sulfate Induces CYP1A2 In Primary Human Hepatocytes promotion: free to download

Volume: 10   Issue: 3
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Volume: 10   Issue: 3
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Volume: 10   Issue: 3
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Application of a “Fit for Purpose” PBPK Model to Investigate the CYP3A4 Induction Potential of Enzalutamide promotion: free to download

Volume: 10   Issue: 3
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CYP2B6 and OPRM1 Receptor Polymorphisms at Methadone Clinics And Novel OPRM1 Haplotypes: A Cross-Sectional Study promotion: free to download

Volume: 10   Issue: 3
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Ahmad Abdulrahman AlMeman, Rusli Ismail and Markus Perola
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New Screening Criteria Setting on Evaluation of Cytochrome P450 Induction Using HepaRG Cells with Multiplex Branched DNA Technologies in Early Drug Discovery promotion: free to download

Volume: 10   Issue: 3
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Volume: 10   Issue: 2
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