Drug Metabolism Letters

Cytochrome P450 3A4 Induction: Lumacaftor versus Ivacaftor Potentially Resulting in Significantly Reduced Plasma Concentration of Ivacaftor open access plus

Volume:12   Issue:1
Pp: 71-74
Elena K. Schneider*
DOI: 10.2174/1872312812666180328105259

Utility of Pooled Cryopreserved Human Enterocytes as an In vitro Model for Assessing Intestinal Clearance and Drug-Drug Interactions

Volume:12   Issue:1
Pp: 3-13
Susan Wong, Utkarsh Doshi, Peter Vuong, Ning Liu, Suzanne Tay, Hoa Le, Mika Kosaka, Jane R. Kenny, Albert P. Li and Zhengyin Yan*
DOI: 10.2174/1872312812666171213114422

Characterization of Liver- and Cancer-type-Organic Anion Transporting Polypeptide (OATP) 1B3 Messenger RNA Expression in Normal and Cancerous Human Tissues

Volume:12   Issue:1
Pp: 24-32
Khondoker Alam, Taleah Farasyn, Kai Ding and Wei Yue*
DOI: 10.2174/1872312812666180326110146

Comparison of Rat and Human Pulmonary Metabolism Using Precision-cut Lung Slices (PCLS) open access plus

Volume:13   Issue:1
Pp: 53-63
Yildiz Yilmaz*, Gareth Williams, Markus Walles, Nenad Manevski, Stephan Krähenbühl and Gian Camenisch
DOI: 10.2174/1872312812666181022114622

Evaluation of Herb-Drug Interaction of Synacinn™ and Individual Biomarker through Cytochrome 450 Inhibition Assay

Volume:12   Issue:1
Pp: 62-67
Nur Syukriah Ab Rahman, Fadzilah Adibah Abd Majid*, Mohd Effendy Abd Wahid, Ain Nabihah Zainudin, Siti Nurazwa Zainol, Hassan Fahmi Ismail, Tet Soon Wong, Nirbhay Kumar Tiwari, Sanjeev Giri and Vijaya Bhargava
DOI: 10.2174/1872312812666180314112457

Imatinib Uptake into Cells is Not Mediated by Organic Cation Transporters OCT1, OCT2, or OCT3, But is Influenced by Extracellular pH open access plus

Volume:13   Issue:2
Pp: 102-110
Jaurès Blanc Mettral, Nicolas Faller, Sandra Cruchon, Loïc Sottas, Thierry Buclin, Laurent Schild, Eva Choong, Aimable Nahimana and Laurent A. Decosterd*
DOI: 10.2174/1872312813666190207150207

Use of Cocktail Probe Drugs for Indexing Cytochrome P450 Enzymes in Clinical Pharmacology Studies – Review of Case Studies open access plus

Volume:13   Issue:1
Pp: 3-18
Poonam Giri, Harilal Patel and Nuggehally R. Srinivas*
DOI: 10.2174/1872312812666181119154734

Genistein Affects Expression of Cytochrome P450 (CYP450) Genes in Hepatocellular Carcinoma (HEPG2/C3A) Cell Line open access plus

Volume:12   Issue:2
Pp: 138-144
Sandra R. Lepri, Daniele Sartori, Simone C. Semprebon*, Adrivanio Baranoski, Giuliana C. Coatti and Mario S. Mantovani
DOI: 10.2174/1872312812666180709150440

New Perspectives on Acyl Glucuronide Risk Assessment in Drug Discovery: Investigation of In vitro Stability, In situ Reactivity, and Bioactivation

Volume:12   Issue:2
Pp: 84-92
Mithat Gunduz*, Upendra A. Argikar, Amanda L. Cirello and Jennifer L. Dumouchel
DOI: 10.2174/1872312812666180611113656

In Vitro Drug-Drug Interaction Potential of Sulfoxide and/or Sulfone Metabolites of Albendazole, Triclabendazole , Aldicarb, Methiocarb, Montelukast and Ziprasidone open access plus

Volume:12   Issue:2
Pp: 101-116
Poonam Giri, Lakshmikant Gupta, Sneha Naidu, Vipul Joshi, Nirmal Patel, Shyamkumar Giri and Nuggehally R. Srinivas*
DOI: 10.2174/1872312812666180816164626

Effect of Aqueous Extract of Azadirachta indica Leaves on Pharmacokineics and Pharmacodynamics of Glipizide open access plus

Volume:13   Issue:1
Pp: 19-24
Sugandha Chaudhari*, Shitalkumar Zambad and Mohammed Ali
DOI: 10.2174/1872312812666181106115247

Transport of Bupropion and its Metabolites by the Model CHO and HEK293 Cell Lines open access plus

Volume:13   Issue:1
Pp: 25-36
Lyrialle W. Han, Chunying Gao, Yuchen Zhang, Joanne Wang and Qingcheng Mao*
DOI: 10.2174/1872312813666181129101507

Quantitative Proteomics Reveals Changes in Transporter Protein Abundance in Liver, Kidney and Brain of Mice by Pregnancy open access plus

Volume:12   Issue:2
Pp: 145-152
Michael Z. Liao, Chunying Gao, Deepak Kumar Bhatt, Bhagwat Prasad and Qingcheng Mao*
DOI: 10.2174/1872312812666180625122810

Using LC Retention Times in Organic Structure Determination: Drug Metabolite Identification open access plus

Volume:12   Issue:2
Pp: 93-100
William L. Fitch*, Cyrus Khojasteh, Ignacio Aliagas and Kevin Johnson
DOI: 10.2174/1872312812666180802093347

Hepatic Flavin-containing Monooxygenase and Aldehyde Oxidase Activities in Male Domestic Pigs at Different Ages open access plus

Volume:12   Issue:2
Pp: 125-131
Steven X. Hu*
DOI: 10.2174/1872312812666180913145334

Effects of Tobacco Nicotine-Derived Nitrosamine Ketone (NNK) Exposures on Brain Alcohol Metabolizing Enzyme Activities

Volume:12   Issue:2
Pp: 117-124
Emine B. Yalcin, Ming Tong, Gina Gallucci and Suzanne M. de la Monte*
DOI: 10.2174/1872312812666180611115418

Cytochrome P450 1A2 Messenger RNA is a More Reliable Marker than Cytochrome P450 1A2 Activity, Phenacetin O-Deethylation, for Assessment of Induction Potential of Drug-Metabolizing Enzymes Using HepaRG Cells

Volume:12   Issue:1
Pp: 14-23
Akira Ogasawara*, Nozomu Kato, Nao Torimoto, Fumika Aohara, Rikiya Ohashi, Yasuhiro Yamada and Hideki Taniguchi
DOI: 10.2174/1872312812666180119114013

In vitro Drug Metabolism Investigation of 7-Ethoxycoumarin in Human, Monkey, Dog and Rat Hepatocytes by High Resolution LC-MS/MS open access plus

Volume:12   Issue:1
Pp: 33-53
Wan-Yong Feng*, Jenny Wen and Kathe Stauber
DOI: 10.2174/1872312812666180418142056

LC-MS/MS Identification and Structural Characterization of Main Biodegradation Products of Nitroproston - A Novel Prostaglandin-based Pharmaceutical Compound

Volume:12   Issue:1
Pp: 54-61
Natalia V. Mesonzhnik*, Natalia E. Moskaleva, Ksenia M. Shestakova, Ksenya O. Kurynina, Pavel A. Baranov, Natalia M. Gretskaya, Igor V. Serkov, Igor I. Lyubimov, Vladimir V. Bezuglov and Svetlana A. Appolonova
DOI: 10.2174/1872312812666180309160927

Prominence of Oxidative Stress in the Management of Anti-tuberculosis Drugs Related Hepatotoxicity open access plus

Volume:13   Issue:2
Pp: 95-101
Preena John and Pravin P. Kale*
DOI: 10.2174/1872312813666190716155930

The Effects of Special Patient Population Plasma on Pharmacokinetic Quantifications Using LC-MS/MS open access plus

Volume:13   Issue:2
Pp: 111-122
Dongmei Zhou*, Lifang Sun, Mai Nguyen, Li- Tain Yeh and David M. Wilson
DOI: 10.2174/1872312813666191015162634

Assessment of Inhibition of Bovine Hepatic Cytochrome P450 by 43 Commercial Bovine Medicines Using a Combination of In Vitro Assays and Pharmacokinetic Data from the Literature open access plus

Volume:13   Issue:2
Pp: 123-131
Steven X. Hu*, Chase A. Mazur and Kenneth L. Feenstra
DOI: 10.2174/1872312813666191120094649

A Practical Perspective on the Evaluation of Small Molecule CNS Penetration in Drug Discovery open access plus

Volume:13   Issue:2
Pp: 78-94
Liyue Huang*, Mary C. Wells and Zhiyang Zhao
DOI: 10.2174/1872312813666190311125652

Oral Bioavailability Enhancement of Amisulpride: Complexation and its Pharmacokinetics and Pharmacodynamics Evaluations open access plus

Volume:13   Issue:2
Pp: 132-144
Prajapati Jagruti B.*, Sawant Krutika K. and Bhramanand Dubey
DOI: 10.2174/1872312813666191018152226

“Branched Tail” Oxyquinoline Inhibitors of HIF Prolyl Hydroxylase: Early Evaluation of Toxicity and Metabolism Using Liver-on-a-chip open access plus

Volume:13   Issue:1
Pp: 45-52
Andrey A. Poloznikov*, Sergey V. Nikulin, Arpenik A. Zakhariants, Anna Y. Khristichenko, Dmitry M. Hushpulian, Ildar N. Gazizov, Vladimir I. Tishkov and Irina G. Gazaryan
DOI: 10.2174/1872312813666181129100950