Abstract
A growing number of dominantly inherited neurodegenerative disorders are associated with an expanded polyglutamine-encoding sequence. Alterations in gene expression have been described for several of these diseases. Many animal and cell culture models have been established. In order to generate gene expression profiles of model systems using microarray technology, the Hereditary Disease Array Group (HDAG) was formed. This collaboration helps participants to refine the design, methods, and analyses and to identify potential problem areas. The ultimate goal of HDAG is to elucidate the mechanisms by which expanded polyglutamine tracts contribute to neuropathogenesis. This conference review intends to describe this collaborative effort and highlight some of the issues relating to technical aspects, quality control and bioinformatics as well as therapeutic targets and human samples.
Keywords: Hereditary disease array group hdag microarrays, neurodegenerative disorders, polyglutamine-encoding, hintington disease, huntington disease, spinocerebellar ataxias, spinobulbar muscular atrophy drpla, gene expression, bioinformatics, target validation, disease markers
Current Genomics
Title: The Hereditary Disease Array Group (HDAG) - Microarrays, Models and Mechanisms : A Collaboration Update
Volume: 2 Issue: 3
Author(s): Tim- Rasmus Kiehl, James M. Olson and Stefan M. Pulst
Affiliation:
Keywords: Hereditary disease array group hdag microarrays, neurodegenerative disorders, polyglutamine-encoding, hintington disease, huntington disease, spinocerebellar ataxias, spinobulbar muscular atrophy drpla, gene expression, bioinformatics, target validation, disease markers
Abstract: A growing number of dominantly inherited neurodegenerative disorders are associated with an expanded polyglutamine-encoding sequence. Alterations in gene expression have been described for several of these diseases. Many animal and cell culture models have been established. In order to generate gene expression profiles of model systems using microarray technology, the Hereditary Disease Array Group (HDAG) was formed. This collaboration helps participants to refine the design, methods, and analyses and to identify potential problem areas. The ultimate goal of HDAG is to elucidate the mechanisms by which expanded polyglutamine tracts contribute to neuropathogenesis. This conference review intends to describe this collaborative effort and highlight some of the issues relating to technical aspects, quality control and bioinformatics as well as therapeutic targets and human samples.
Export Options
About this article
Cite this article as:
Kiehl Rasmus Tim-, Olson M. James and Pulst M. Stefan, The Hereditary Disease Array Group (HDAG) - Microarrays, Models and Mechanisms : A Collaboration Update, Current Genomics 2001; 2 (3) . https://dx.doi.org/10.2174/1389202013350878
DOI https://dx.doi.org/10.2174/1389202013350878 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Advanced Computational Algorithms and Artificial Intelligence in Clinical Pharmacogenomics
In the era of personalized medicine, understanding the relationship between genetics and drug response is crucial. This issue delves into innovative methodologies, leveraging deep computational analysis and artificial intelligence, to enhance the field of Clinical Pharmacogenomics. The interdisciplinary approach harnesses the power of advanced high-throughput genotyping technologies, sophisticated computational analysis, ...read more
Applications of Single-cell Sequencing Technology in Reproductive Medicine
Single cell sequencing (SCS) technology utilizes individual cells' genetic material to sequence their genome, transcriptome, and epigenetics at the molecular level. It offers insights into cell heterogeneity and enables the study of limited biological materials. Since its recognition as a valuable technique in 2011, single cell sequencing has yielded numerous ...read more
Big Data in Cancer Research
Cancer is a significant threat to human life and health, remaining a highly aggressive killer. It is a leading cause of death worldwide and represents a crucial medical issue for humanity. However, in the past decade, the effectiveness of new synthetic anticancer agents has not matched the current clinical speculation. ...read more
Current Genomics in Cardiovascular Research
Cardiovascular diseases are the main cause of death in the world, in recent years we have had important advances in the interaction between cardiovascular disease and genomics. In this Research Topic, we intend for researchers to present their results with a focus on basic, translational and clinical investigations associated with ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Therapeutic, Molecular and Computational Aspects of Novel Monoamine Oxidase (MAO) Inhibitors
Combinatorial Chemistry & High Throughput Screening A Dual Mechanism Linking NGF/proNGF Imbalance and Early Inflammation to Alzheimer's Disease Neurodegeneration in the AD11 Anti-NGF Mouse Model
CNS & Neurological Disorders - Drug Targets Protein Aggregation in Alzheimers Disease and Other Neoropathological Disorders
Current Alzheimer Research Neuroinflammation and Alzheimer's Disease: Implications for Microglial Activation
Current Alzheimer Research Amyotrophic Lateral Sclerosis and Oxidative Stress: A Double-Blind Therapeutic Trial After Curcumin Supplementation
CNS & Neurological Disorders - Drug Targets The Quest for Novel Biomarkers in Early Diagnosis of Diabetic Neuropathy
Current Proteomics Programmed Cell Death Mechanisms in Neurological Disease
Current Molecular Medicine Cell-Replacement Therapy with Stem Cells in Neurodegenerative Diseases
Current Neurovascular Research Dangerous Liaisons: Tau Interaction with Muscarinic Receptors
Current Alzheimer Research C-terminus of Hsp70 Interacting Protein (CHIP) and Neurodegeneration: Lessons from the Bench and Bedside
Current Neuropharmacology Neurobiological and Psychosocial Processes Associated with Depressive and Substance-Related Disorders in Adolescents
Current Drug Abuse Reviews The Endocannabinoid System in Amyotrophic Lateral Sclerosis
Current Pharmaceutical Design Roles of p97-Associated Deubiquitinases in Protein Quality Control at the Endoplasmic Reticulum
Current Protein & Peptide Science New Molecular Avenues in Parkinson ’ s Disease Therapy
Current Topics in Medicinal Chemistry Apathy: A Conceptual Review
Current Psychiatry Research and Reviews Anti-oxidant and Antiproliferative Activities of Mongolian Medicinal Plant Extracts and Structure Isolation of Gnetin-H Compound
Medicinal Chemistry Regulatory Cascade of Neuronal Loss and Glucose Metabolism
CNS & Neurological Disorders - Drug Targets Editorial (Mini Hot-Topic: Determination of the Antioxidant Capacity of Dietary Substances and Extracts from Natural Sources at Molecular, Cellular And Whole Tissue Level: Sensors and Complex Microfluidic Structures)
Current Analytical Chemistry Structure Diversity, Synthesis, and Biological Activity of Cyathane Diterpenoids in Higher Fungi
Current Medicinal Chemistry Extracellular Vesicles in the Treatment of Parkinson’s Disease: A Review
Current Medicinal Chemistry