CNS & Neurological Disorders - Drug Targets

Targeting the PI3K/AKT/mTOR Signaling Pathway in Primary Central Nervous System Lymphoma: Current Status and Future Prospects

Volume: 19   Issue: 3
Pp: 165-173
Xiaowei Zhang and Yuanbo Liu *
DOI: 10.2174/1871527319666200517112252

The Combination of rTMS and Pharmacotherapy on in vitro Models: A Mini-Review

Volume: 19   Issue: 3
Pp: 220-226
Chryssa Pourzitaki*, Ioannis Dardalas, Frideriki Poutoglidou, Dimitrios Kouvelas and Vasilios K. Kimiskidis
DOI: 10.2174/1871527319666200518100716

Interlink between Insulin Resistance and Neurodegeneration with An Update on Current Therapeutic Approaches

Volume: 19   Issue: 3
Pp: 174-183
Subrat Kumar Bhattamisra*, Lee Yuen Shin, Hanis Izzati Binti Mohd Saad, Vikram Rao, Mayuren Candasamy, Manisha Pandey and Hira Choudhury
DOI: 10.2174/1871527319666200518102130

Overview of Therapeutic Drugs and Methods for the Treatment of Parkinson’s Disease

Volume: 19   Issue: 3
Pp: 195-206
Andrew Schneider, Adam T. Sari, Hasan Alhaddad and Youssef Sari*
DOI: 10.2174/1871527319666200525011110

The β-Secretase Enzyme BACE1: A Biochemical Enigma for Alzheimer’s Disease

Volume: 19   Issue: 3
Pp: 184-194
Hirak Shah, Ashish Patel*, Vruti Parikh, Afzal Nagani, Bhargav Bhimani, Umang Shah and Tushar Bambharoliya
DOI: 10.2174/1871527319666200526144141

In Vitro and In Vivo Neuroprotective Effects of Etifoxine in β-Amyloidinduced Toxicity Models

Volume: 19   Issue: 3
Pp: 227-240
Veronique Riban *, Johann Meunier , Dorothee Buttigieg, Vanessa Villard and Marc Verleye
DOI: 10.2174/1871527319666200601151007

A Pivotal Role of the Nrf2 Signaling Pathway in Spinal Cord Injury: A Prospective Therapeutics Study

Volume: 19   Issue: 3
Pp: 207-219
Saeed Samarghandian, Ali Mohammad Pourbagher-Shahri, Milad Ashrafizadeh, Haroon Khan, Fatemeh Forouzanfar, Hamed Aramjoo and Tahereh Farkhondeh*
DOI: 10.2174/1871527319666200604175118

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Volume: 19   Issue: 3
Pp: 163-164
Caterina Bendotti
DOI: 10.2174/187152731903200625151510

Stingless Bee Honey Reduces Anxiety and Improves Memory of the Metabolic Disease-induced Rats

Volume: 19   Issue: 2
Pp: 115-126
Nurul ‘Ain Arshad, Teoh Seong Lin and Mohamad Fairuz Yahaya*
DOI: 10.2174/1871527319666200117105133

Sialuria-Related Intellectual Disability in Children and Adolescent of Pakistan: Tenth Patient Described has a Novel Mutation in the GNE Gene

Volume: 19   Issue: 2
Pp: 127-141
Hina Ishtiaq, Sonia Siddiqui*, Rukhsana Nawaz, Khawar Saeed Jamali and Abdul Ghani Khan
DOI: 10.2174/1871527319666200213115747

Scopolamine, a Toxin-Induced Experimental Model, Used for Research in Alzheimer’s Disease

Volume: 19   Issue: 2
Pp: 85-93
Win Ning Chen and Keng Yoon Yeong*
DOI: 10.2174/1871527319666200214104331

Risk Analysis of Lurasidone in Patients with Schizophrenia and Bipolar Depression

Volume: 19   Issue: 2
Pp: 109-114
Harika Modugula and Anoop Kumar*
DOI: 10.2174/1871527319666200303120147

Oxidative Stress in the Pathogenesis of Alzheimer’s Disease and Cerebrovascular Disease with Therapeutic Implications

Volume: 19   Issue: 2
Pp: 94-108
Anamaria Jurcau* and Aurel Simion
DOI: 10.2174/1871527319666200303121016

CSF Levels of the Endocannabinoid Anandamide are Reduced in Patients with Untreated Narcolepsy Type 1: A Pilot Study

Volume: 19   Issue: 2
Pp: 142-147
Andrea Romigi*, Monica Bari, Claudio Liguori, Francesca Izzi, Cinzia Rapino, Marzia Nuccetelli, Natalia Battista, Sergio Bernardini, Diego Centonze, Nicola Biagio Mercuri, Fabio Placidi and Mauro Maccarrone
DOI: 10.2174/1871527319666200309115602

Early Expression of Neuronal Dopaminergic Markers in a Parkinson’s Disease Model in Rats Implanted with Enteric Stem Cells (ENSCs)

Volume: 19   Issue: 2
Pp: 148-162
Carmen Parra-Cid*, Eduardo Orozco-Castillo, Julieta García-López, Elena Contreras-Figueroa, Laura E. Ramos-Languren, Clemente Ibarra, Alfonso Carreón-Rodríguez, Michael Aschner, Mina Königsberg and Abel Santamaría*
DOI: 10.2174/1871527319666200417123948

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Volume: 19   Issue: 2
Pp: 83-84
Sergio Machado
DOI: 10.2174/187152731902200514092436

Madecassic Acid Reduces Fast Transient Potassium Channels and Promotes Neurite Elongation in Hippocampal CA1 Neurons

Volume: 19   Issue: 1
Pp: 12-26
Sonia Siddiqui*, Faisal Khan , Khawar Saeed Jamali and Syed Ghulam Musharraf
DOI: 10.2174/1871527318666191111105508

Pharmacokinetics and Acute Toxicity of a Histone Deacetylase Inhibitor, Scriptaid, and its Neuroprotective Effects in Mice After Intracranial Hemorrhage

Volume: 19   Issue: 1
Pp: 55-65
Heng Yang, Xinjie Gao, Jiabin Su, Hanqiang Jiang, Yu Lei, Wei Ni* and Yuxiang Gu*
DOI: 10.2174/1871527319666191220111126

Plasma Indoleamine-2,3-Dioxygenase (IDO) is Increased in Drug-Naï ve Major Depressed Patients and Treatment with Sertraline and Ketoprofen Normalizes IDO in Association with Pro-Inflammatory and Immune- Regulatory Cytokines

Volume: 19   Issue: 1
Pp: 44-54
Hussein Kadhem Al-Hakeim , Ahmed Jasim Twayej, Arafat Hussein Al-Dujaili and Michael Maes*
DOI: 10.2174/1871527319666200102100307

The Role of Annexin A1 and Formyl Peptide Receptor 2/3 Signaling in Chronic Corticosterone-Induced Depression-Like behaviors and Impairment in Hippocampal-Dependent Memory

Volume: 19   Issue: 1
Pp: 27-43
Alessio Filippo Peritore, Rosalia Crupi, Maria Scuto, Enrico Gugliandolo, Rosalba Siracusa, Daniela Impellizzeri, Marika Cordaro, Ramona D’amico, Roberta Fusco, Rosanna Di Paola and Salvatore Cuzzocrea*
DOI: 10.2174/1871527319666200107094732

BDNF-TrkB and proBDNF-p75NTR/Sortilin Signaling Pathways are Involved in Mitochondria-Mediated Neuronal Apoptosis in Dorsal Root Ganglia after Sciatic Nerve Transection

Volume: 19   Issue: 1
Pp: 66-82
Xianbin Wang, Wei Ma, Tongtong Wang, Jinwei Yang, Zhen Wu, Kuangpin Liu, Yunfei Dai, Chenghao Zang, Wei Liu, Jie Liu, Yu Liang, Jianhui Guo* and Liyan Li*
DOI: 10.2174/1871527319666200117110056

Neuronal Excitability in Epileptogenic Zones Regulated by the Wnt/ Β-Catenin Pathway

Volume: 19   Issue: 1
Pp: 2-11
Carmen Rubio, Elisa Taddei, Jorge Acosta, Verónica Custodio and Carlos Paz*
DOI: 10.2174/1871527319666200120143133

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Volume: 19   Issue: 1
Pp: 1-1
Sadayuki Hashioka
DOI: 10.2174/187152731901200316111017

Current and Future of Alzheimer's Therapy with the best Approach

Volume: 19   Issue:
Pp: 1-7
Harminder Singh, Viney Chawla*, Ritu Bala and Harish Dureja
DOI: 10.2174/1871527319666200430000538

Evidence on the New Drug Lumateperone (ITI-007) for Psychiatric and Neurological Disorders

Volume: 19   Issue:
Pp: 1-5
Marianna Mazza*, Giuseppe Marano, Gianandrea Traversi, Gabriele Sani and Luigi Janiri
DOI: 10.2174/1871527319666200601145653

Topiramate Decelerates Bicarbonate-Driven Acid-Elimination of Human Neocortical Neurons: Strategic Significance for its Antiepileptic, Antimigraine and Neuroprotective Properties

Volume: 19   Issue:
Pp: 1-12
Udo Bonnet* and Martin Wiemann
DOI: 10.2174/1871527319666200604173208

Yishen Huazhuo Decoction Induces Autophagy to Promote the Clearance of Aβ1-42 in SAMP8 Mice: Mechanism Research of a Traditional Chinese Formula Against Alzheimer’s Disease

Volume: 19   Issue:
Pp: 1-14
Kai Wang, Weiming Sun, Jiachun Xu, Qijing Qin, Zhen Yu, Ruzhen Cheng, Linlin Zhang, Shuang Liu, Zhen Zhou, Yulian Zhang* and Yuanwu Cui
DOI: 10.2174/1871527319666200604174223

When Sick Brain and Hopelessness Meet: Some Aspects of Suicidality in the Neurological Patient

Volume: 19   Issue:
Pp: 1-7
A. Costanza*, A. Amerio, A. Aguglia, A. Escelsior, G. Serafini, I. Berardelli, M. Pompili and M. Amore
DOI: 10.2174/1871527319666200611130804

Lisdexamfetamine Alters BOLD-fMRI Activations Induced by Odor Cues in Impulsive Children

Volume: 19   Issue:
Pp: 1-16
Silvia S. Hidalgo Tobón, Pilar Dies Suárez, Eduardo Barragán Pérez, Javier M. Hernández López, Julio García and Benito de Celis Alonso*
DOI: 10.2174/1871527319666200613222502

MAPK: A Key Player in the Development and Progression of Stroke

Volume: 19   Issue:
Pp: 1-9
Yangmin Zheng, Ziping Han, Haiping Zhao and Yumin Luo*
DOI: 10.2174/1871527319666200613223018

The locus of Action of CGRPergic Monoclonal Antibodies Against Migraine: Peripheral Over Central Mechanisms

Volume: 19   Issue:
Pp: 1-16
Abimael González-Hernández, Bruno A. Marichal-Cancino, Enrique García-Boll and Carlos M. Villalón*
DOI: 10.2174/1871527319666200618144637

Transdermal Drug Delivery Systems and their Potential in Alzheimer’s Disease Management

Volume: 19   Issue:
Pp: 1-14
Panoraia I. Siafaka, Ece Özcan Bülbül, Gökce Mutlu, Mehmet EvrenOkur, Ioannis D. Karantas and Neslihan Üstündağ Okur*
DOI: 10.2174/1871527319666200618150046

Metabolic Adjustments by LncRNAs in Peripheral Neutrophils Partly Account for the Complete Compensation of Asymptomatic MMD Patients

Volume: 19   Issue:
Pp: 1-12
Ziping Han, Lingzhi Li, Ping Liu, Yuyou Huang, Sijia Zhang, Guangwen Li, Fangfang Li, Haiping Zhao, Zhen Tao, Rongliang Wang, Qingfeng Ma and Yumin Luo*
DOI: 10.2174/1871527319666200618150827

Inflammation and Mitochondrial Dysfunction in Autism Spectrum Disorder

Volume: 19   Issue:
Pp: 1-14
Maria Gevezova, Victoria Sarafian*, George Anderson and Michael Maes
DOI: 10.2174/1871527319666200628015039

Resolution-Associated Molecular Patterns (RAMPs) as Endogenous Regulators of Glia Functions in Neuroinflammatory Disease

Volume: 19   Issue:
Pp: 1-12
Tyler J. Wenzel, Evan Kwong, Ekta Bajwa and Andis Klegeris*
DOI: 10.2174/1871527319666200702143719

Tumor Treating Fields – Behind and Beyond Inhibiting the Cancer Cell Cycle

Volume: 19   Issue:
Pp: 1-12
Cédric Kissling and Stefano Di Santo*
DOI: 10.2174/1871527319666200702144749

Modeling Parkinson’s Disease in Zebrafish

Volume: 19   Issue:
Pp: 1-14
Nor Haliza Mohamad Najib, Yong Hui Nies, Syarifah Aisyah Syed Abd Halim, Mohamad Fairuz Yahaya, Srijit Das, Wei Ling Lim and Seong Lin Teoh*
DOI: 10.2174/1871527319666200708124117

Road From Nose to Brain for Treatment of Alzheimer: The Bumps and Humps

Volume: 19   Issue:
Pp: 1-13
Rajesh Kumar, Monica Gulati, Sachin Kumar Singh, Deepika Sharma and Omji Porwal*
DOI: 10.2174/1871527319666200708124726

Microglial Cathepsin B and Porphyromonas gingivalis Gingipains as Potential Therapeutic Targets for Sporadic Alzheimer’s Disease

Volume: 19   Issue:
Pp: 1-8
Hiroshi Nakanishi*, Saori Nonaka and Zhou Wu
DOI: 10.2174/1871527319666200708125130

Radiotherapy and Its Impact on the Nervous System of Cancer Survivors

Volume: 19   Issue:
Pp: 1-12
Gautam Kumar, Priyadarshini Dutta, Vipan K. Parihar, Mallikarjuna Rao Chamallamudi and Nitesh Kumar*
DOI: 10.2174/1871527319666200708125741

Impact of Cannabis-Based Medicine on Alzheimer’s Disease by Focusing on the Amyloid β-Modifications: A Systematic Study

Volume: 19   Issue:
Pp: 1-10
Tahereh Farkhondeh, Haroon Khan, Michael Aschner, Fariborz Samini, Ali Mohammad Pourbagher-Shahri, Hamed Aramjoo, Babak Roshanravan, Christopher Hoyte, Omid Mehrpour and Saeed Samarghandian*
DOI: 10.2174/1871527319666200708130745

Quantitative Characterization of Phenotypical Markers After Differentiation of SH-SY5Y Cells

Volume: 19   Issue:
Pp: 1-12
Angélique D. Ducray, Linda Wiedmer, Fabienne Herren, Hans Rudolf Widmer and Meike Mevissen*
DOI: 10.2174/1871527319666200708132716

Autoimmune Encephalitis: Current Knowledge on Subtypes, Disease Mechanisms and Treatment

Volume: 19   Issue:
Pp: 1-15
Mette Scheller Nissen, Matias Ryding, Morten Meyer and Morten Blaabjerg*
DOI: 10.2174/1871527319666200708133103

Neural Receptors Associated with Depression: a Systematic Review of the Past 10 Years

Volume: 19   Issue:
Pp: 1-20
Alice Barros Câmara* and Igor Augusto Brandão
DOI: 10.2174/1871527319666200715102430

Current Strategies and Novel Drug Approaches for Alzheimer Disease

Volume: 19   Issue:
Pp: 1-15
Roma Ghai*, Kandasamy Nagarajan, Meenakshi Arora, Parul Grover, Nazakat Ali and Garima Kapoor
DOI: 10.2174/1871527319666200717091513

Management of Impulse Control Disorders with Subthalamic Nucleus Deep Brain Stimulation in Parkinson’s Disease

Volume: 19   Issue:
Pp: 1-7
Deborah Amstutz, Steffen Paschen, Martin Lenard Lachenmayer, Marie Elise Maradan-Gachet, Günther Deuschl, Paul Krack and Ines Debove*
DOI: 10.2174/1871527319666200720105553

The Role of Statins in the Management of Delirium: Recent Advances

Volume: 19   Issue:
Pp: 1-13
Junhui Chen, Yuhai Wang, Ximin Hu, Mingchang Li, Kun Xiong, Zhaocai Zhang and Qianxue Chen*
DOI: 10.2174/1871527319666200720111318

Levodopa Therapy for Parkinson's Disease: History, Current Status and perspectives

Volume: 19   Issue:
Pp: 1-12
Helle Bogetofte, Arezo Alamyar, Morten Blaabjerg and Morten Meyer*
DOI: 10.2174/1871527319666200722153156

Prospective Function of Different Antioxidant Containing Natural Products in the Treatment of Neurodegenerative Disease

Volume: 19   Issue:
Pp: 1-13
Md. Habibur Rahman, Rokeya Akter and Mohammad Amjad Kamal*
DOI: 10.2174/1871527319666200722153611

Microbiota-Immune System Interactions in Human Neurological Disorders

Volume: 19   Issue:
Pp: 1-18
Qin Huang, Fang Yu, Di Liao and Jian Xia*
DOI: 10.2174/1871527319666200726222138

Fibrosis and Regulation of Nerve Regeneration in the Peripheral and Central Nervous Systems

Volume: 19   Issue:
Pp: 1-12
Nilabh Ghosh, Daniel Kalbermatten, Srinivas Madduri and Raphael Guzman*
DOI: 10.2174/1871527319666200726222558

Low Serum Levels of Fibroblast Growth Factor 2 in Gunn Rats: A Hyperbilirubinemia Animal Model of Schizophrenic Symptoms

Volume: 19   Issue:
Pp: 1-6
Maiko Hayashida*, Sadayuki Hashioka*, Kenji Hayashida, Shoko Miura, Keiko Tsuchie, Tomoko Araki, Muneto Izuhara, Misako Kanayama, Koji Otsuki, Michiharu Nagahama, Muhammad Alim Jaya, Ryosuke Arauchi, Rei Wake, Arata Oh-Nishi, Jun Horiguchi, Tsuyoshi Miyaoka, Masatoshi Inagak and Eishin Morita
DOI: 10.2174/1871527319999200729153907

Regulatory Role Of Chinese Herbal Medicine In Regulated Neuronal Death

Volume: 19   Issue:
Pp: 1-26
Xiuyu Wu, Ximin Hu, Qi Zhang, Fengxia Liu and Kun Xiong*
DOI: 10.2174/1871527319666200730165011

Integrated system pharmacology and in silico analysis elucidate neuropharmacological actions of Withania somnifera in the treatment of Alzheimer’s disease

Volume: 19   Issue:
Pp: 1-17
Md. Abdul Hannan, Raju Dash, Md. Nazmul Haque, Sung Min Choi and Il Soo Moon*
DOI: 10.2174/1871527319999200730214807

Somatostatin Type 2 Receptor Antibody Enhances Mechanical Hyperalgesia in the Dorsal Root Ganglion Neurons after Sciatic Nerve-pinch Injury: Evidence of Behavioral Studies and Bax Protein Expression

Volume: 18   Issue: 10
Pp: 791-797
Qiong Xiang, Jing-Jing Li, Chun-Yan Li, Rong-Bo Tian and Xian-Hui Li*
DOI: 10.2174/1871527318666191101094412

Neurobehavioral Consequences Associated with Long Term Tramadol Utilization and Pathological Mechanisms

Volume: 18   Issue: 10
Pp: 758-768
Khadga Raj, Pooja Chawla and Shamsher Singh*
DOI: 10.2174/1871527318666191112124435

Structurally Related Edaravone Analogues: Synthesis, Antiradical, Antioxidant, and Copper-Chelating Properties

Volume: 18   Issue: 10
Pp: 779-790
Alexandre LeBlanc, Miroslava Cuperlovic-Culf, Pier Jr. Morin and Mohamed Touaibia*