CNS & Neurological Disorders - Drug Targets

(Formerly Current Drug Targets - CNS & Neurological Disorders)


Edoardo Spina
Department of Clinical and Experimental Medicine
University of Messina
Policlinico Universitario
Via Consolare Valeria

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Most Cited Article

Dl-3-n-Butylphthalide (NBP): A Promising Therapeutic Agent for Ischemic Stroke

Volume:17   Issue:5
Pp: 338-347
Shan Wang, Fei Ma, Longjian Huang, Yong Zhang, Yuchen Peng, Changhong Xing, Yipu Feng, Xiaoliang Wang* and Ying Peng*
DOI: 10.2174/1871527317666180612125843

The Underlying Role of Oxidative Stress in Neurodegeneration: A Mechanistic Review

Volume:17   Issue:3
Pp: 207-215
Habib Yaribeygi, Yunes Panahi*, Behjat Javadi and Amirhossein Sahebkar*
DOI: 10.2174/1871527317666180425122557

Oxidative Stress: Major Threat in Traumatic Brain Injury

Volume:17   Issue:9
Pp: 689-695
Nidhi Khatri, Manisha Thakur, Vikas Pareek, Sandeep Kumar, Sunil Sharma and Ashok Kumar Datusalia*
DOI: 10.2174/1871527317666180627120501

Protective Effect of Kaempferol on the Transgenic Drosophila Model of Alzheimer’s Disease

Volume:17   Issue:6
Pp: 421-429
Tanveer Beg, Smita Jyoti, Falaq Naz, Rahul, Fahad Ali, Syed Kashif Ali, Ahmed Mohamed Reyad and Yasir Hasan Siddique*
DOI: 10.2174/1871527317666180508123050

Autophagy and Mitochondria: Targets in Neurodegenerative Disorders

Volume:17   Issue:9
Pp: 696-705
Ashutosh Kumar*, Amruta Dhawan, Alknanda Kadam and Akshada Shinde
DOI: 10.2174/1871527317666180816100203

A New Schizophrenia Model: Immune Activation is Associated with the Induction of Different Neurotoxic Products which Together Determine Memory Impairments and Schizophrenia Symptom Dimensions promotion: free to download

Volume:18   Issue:2
Pp: 124-140
Sunee Sirivichayakul, Buranee Kanchanatawan, Supaksorn Thika, André F. Carvalho and Michael Maes*
DOI: 10.2174/1871527317666181119115532

NF-κB as a Key Mediator of Brain Inflammation in Alzheimer’s Disease promotion: free to download

Volume:18   Issue:1
Pp: 3-10
Chul Ju Hwang, Dong-Young Choi, Mi Hee Park and Jin Tae Hong*
DOI: 10.2174/1871527316666170807130011

Metabolic Syndrome and Its Effect on the Brain: Possible Mechanism

Volume:17   Issue:8
Pp: 595-603
Nurul ‘Ain Arshad, Teoh Seong Lin and Mohamad Fairuz Yahaya*
DOI: 10.2174/1871527317666180724143258

Therapeutic Advancement in Alzheimer Disease: New Hopes on the Horizon?

Volume:17   Issue:8
Pp: 571-589
Ajeet Singh, Abshar Hasan, Sakshi Tiwari and Lalit M. Pandey*
DOI: 10.2174/1871527317666180627122448

Oleanolic Acid Ameliorates Aβ25-35 Injection-induced Memory Deficit in Alzheimer’s Disease Model Rats by Maintaining Synaptic Plasticity open access plus

Volume:17   Issue:5
Pp: 389-399
Kai Wang, Weiming Sun, Linlin Zhang, Wei Guo, Jiachun Xu, Shuang Liu, Zhen Zhou and Yulian Zhang*
DOI: 10.2174/1871527317666180525113109

Diabetes Mellitus to Neurodegenerative Disorders: Is Oxidative Stress Fueling the Flame?

Volume:17   Issue:9
Pp: 644-653
Nandkishor K. Mule and Jitendra N. Singh*
DOI: 10.2174/1871527317666180809092359

Development of a Nasal Donepezil-loaded Microemulsion for the Treatment of Alzheimer’s Disease: in vitro and ex vivo Characterization

Volume:17   Issue:1
Pp: 43-53
Lupe C. Espinoza, Marisol Vacacela, Beatriz Clares*, Maria Luisa Garcia, Maria-Jose Fabrega and Ana C. Calpena
DOI: 10.2174/1871527317666180104122347

Amyotrophic Lateral Sclerosis and Oxidative Stress: A Double-Blind Therapeutic Trial After Curcumin Supplementation

Volume:17   Issue:10
Pp: 767-779
Lucia Chico*, Elena Caldarazzo Ienco, Costanza Bisordi, Annalisa Lo Gerfo, Lucia Petrozzi, Antonio Petrucci, Michelangelo Mancuso and Gabriele Siciliano
DOI: 10.2174/1871527317666180720162029

Hydrogen Sulfide in Physiological and Pathological Mechanisms in Brain

Volume:17   Issue:9
Pp: 654-670
Mohit Kumar and Rajat Sandhir*
DOI: 10.2174/1871527317666180605072018

In Silico Analyses for Key Genes and Molecular Genetic Mechanism in Epilepsy and Alzheimer’s Disease

Volume:17   Issue:8
Pp: 608-617
Xiao-wen Jiang, Hong-yuan Lu, Ziru Xu, Tian-yi Liu, Qiong Wu, Yue Yang, Qing-chun Zhao* and Hui-yuan Gao*
DOI: 10.2174/1871527317666180724150839

The Yin and Yang of BK Channels in Epilepsy

Volume:17   Issue:4
Pp: 272-279
Yudan Zhu, Shuzhang Zhang, Yijun Feng, Qian Xiao, Jiwei Cheng* and Jie Tao*
DOI: 10.2174/1871527317666180213142403

The Large Conductance Calcium- and Voltage-activated Potassium Channel (BK) and Epilepsy

Volume:17   Issue:4
Pp: 248-254
Kai Zang, Yuwen Zhang, Jie Hu and Yun Wang*
DOI: 10.2174/1871527317666180404104055

Epigenetics in Neurodegenerative Diseases: The Role of Histone Deacetylases promotion: free to download

Volume:18   Issue:1
Pp: 11-18
Sorabh Sharma, K.C. Sarathlal and Rajeev Taliyan*
DOI: 10.2174/1871527317666181004155136

A Novel Combination of ω-3 Fatty Acids and Nano-Curcumin Modulates Interleukin-6 Gene Expression and High Sensitivity C-reactive Protein Serum Levels in Patients with Migraine: A Randomized Clinical Trial Study

Volume:17   Issue:6
Pp: 430-438
Mina Abdolahi, Payam Sarraf, Mohammad Hassan Javanbakht, Niyaz Mohammadzadeh Honarvar, Mahsa Hatami, Neda Soveyd, Abbas Tafakhori, Mohsen Sedighiyan, Mona Djalali, Arash Jafarieh, Yousef Masoudian and Mahmoud Djalali*
DOI: 10.2174/1871527317666180625101643

A Review on Possible Therapeutic Effect of Nigella sativa and Thymoquinone in Neurodegenerative Diseases

Volume:17   Issue:6
Pp: 412-420
Saeed Samarghandian, Tahereh Farkhondeh* and Fariborz Samini
DOI: 10.2174/1871527317666180702101455

C-Abl Inhibition; A Novel Therapeutic Target for Parkinson's Disease

Volume:17   Issue:1
Pp: 14-21
Abdelrahman Ibrahim Abushouk, Ahmed Negida*, Rasha Abdelsalam Elshenawy, Hossam Zein, Ali M. Hammad, Ahmed Menshawy and Wael M.Y. Mohamed
DOI: 10.2174/1871527316666170602101538

Effect of Neuroinflammation on ABC Transporters: Possible Contribution to Refractory Epilepsy

Volume:17   Issue:10
Pp: 728-735
Xiaolin Deng, Yangmei Xie and Yinghui Chen*
DOI: 10.2174/1871527317666180828121820

Characterization of Regulatory T-Cells in Multiple Sclerosis Patients Treated with Interferon Beta-1a

Volume:17   Issue:2
Pp: 113-118
Mohsen Ebrahimimonfared, Ali Ganji, Sara Zahedi, Parisa Nourbakhsh, Keyvan Ghasami and Ghasem Mosayebi*
DOI: 10.2174/1871527317666180327122435