Current Drug Discovery Technologies

Editor-in-Chief

Vladimir P. Torchilin
(68301 citations)
Department of Pharmaceutical Science Center for Pharmaceutical Biotechnology and Nanomedicine
Northeastern University
Boston, MA 02115
(USA)

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Articles Ahead of Print

Molecular modelling studies on thiazole-based α-Glucosidase Inhibitor using docking and CoMFA, CoMSIA and HQSAR

Volume:17
Deshbandhu Joshi*, Shourya Yadav, Rajesh Sharma, Mitrunjaya Pandya and Raghvendra Singh Bhadauria

The Effects of Herbal Medicines on Women Sexual Dysfunction: A Systematic Review

Volume:17
Tahereh Molkara, Maliheh Motavasselian, Farideh Akhlaghi, Mohammad Arash Ramezani , Hamideh Naghedi Baghdar, Seyed Majid Ghazanfari and Roshanak Salari*

A New Series Of 1,3-Dimethylxanthine Based Adenosine A2a Receptor Antagonists As A Non-Dopaminergic Treatment Of Parkinson’s Disease

Volume:17
Suman Rohilla, Ranju Bansal*, Puneet Chauhan, Sonja Kachler and Karl-Norbert Klotz

Bronchospasmolytic and Adenosine Binding Activity of 8- (Proline / Pyrazole)- Substituted Xanthine Derivatives

Volume:17
Sneha Singh, Madhwi Ojha, Divya Yadav, Sonja Kachler, Karl-Norbert Klotz and Rakesh Yadav*

Assessment of Biochemical Determinants in Multiple Sclerosis Patients Following the Oral Administration of β-D-Mannuronic Acid (M2000)

Volume:17
Mohamad Reza Nikouei Moghaddam*, Monireh Movahedi, Maryam Bananej, Soheil Najafi, Nahid Beladi Moghadam, Payam Saadat, Fariba Mokhtarian and Abbas Mirshafiey

Identification of Main Protease of Coronavirus SARS-CoV-2 (Mpro) Inhibitors from Melissa officinalis

Volume:17
Olusola O. Elekofehinti*, Opeyemi Iwaloye, Courage D. Famusiwa, Olanrewaju Akinseye and Joao B. T. Rocha

A Comparative Survey on Antioxidant Activity of Iranian Shrimp Waste [Penaeus Semisulcatus] and Synthetic Antioxidants

Volume:17
Naiema Vakili Saatloo, Leila Peivasteh-Roudsari, Hadi Eghbaljoo gharehgheshlaghi, Gholamreza Jahed Khaniki, Ramin Nabizadeh Nodehi, Mahmood Alimohammadi and Parisa Sadighara*

Synthesis and Study of Some 17a-aza-D-homo Steroids as 5α-Reductase Inhibitors

Volume:17
Priyanka Rana, Neelima Dhingra*, Poonam Arora, Richa Dhingra, Monika Chauhan and Ankit Gupta

Extraction, Chemical Composition, Antioxidant Property, and In-vitro Anticancer Activity of Silymarin from Silybum marianum on Kb and A549 Cell Lines

Volume:17
Mojgan Azadpour, Mohammad Mehdi Farajollahi, Ali Mohammad Varzi, Pejman Hashemzadeh, Hossein Mahmoudvand and Mitra Barati*

COVID-19 Infection and Vitamin D: Current Scenario and Future Prospects

Volume:17
Leila Peivasteh-Roudsari, Behrouz Tajdar-Oranj and Parisa Sadighara*

Discovery of Traditional Chinese Medicine Derived Compounds as Wild Type and Mutant Plasmodium falciparum Dihydrofolate Reductase Inhibitors: Induced Fit Docking and ADME Studies

Volume:17
Opeyemi Iwaloye*, Olusola Olalekan Elekofehinti, Babatomiwa Kikiowo, Toyin Mary Fadipe, Moses Orimoloye Akinjiyan, Esther Opeyemi Ariyo, Olabisi Olapade Aiyeku and Nicholas Adeyemi Adewumi

Molecular Context of ADP-ribosylation in Schistosomes for Drug Discovery and Vaccine Development

Volume:17
Amandla Chutshela, Priscilla Masamba, Babatunji Emmanuel Oyinloye and Abidemi Paul Kappo*

Anti-cancer effect of Urginea maritima bulb extract invitro through cell cycle arrest and induction of apoptosis in human breast cancer cell lines

Volume:17
Khadije Saket, Roshanak Salari, Ehsan Saburi, Mahdi Yousefi, Mohammad Ali Khodadoust, Mahdieh Hadi and Jalil Tavakol afshari*

The Effect of Myrtus communis Aqueous Extract-Containing Gel on Wound Healing in Streptozotocin-Induced Diabetic Rats

Volume:17
Seyed-Ali Khodaie, Fatemeh Emadi, Mohsen Naseri, Mohammad Kamalinejad, Seyed Mohammad Riahi, Fatemeh Alijaniha and Mehrdad Roghani*

Potential Fatty Acid as Antibacterial Agent Against Oral Bacteria of Streptococcus mutans and Streptococcus sanguinis from Basil (Ocimum americanum): In vitro and in silico Studies

Volume:17
Yetty Herdiyati, Yonada Astrid, Aldina Amalia Nur Shadrina, Ika Wiani, Mieke Hemiawati Satari and Dikdik Kurnia*

The Toxicity Effect of Echium amoenum on the Liver and Kidney of Mice

Volume:17
Mozhgan Ghorbani, Atefeh Araghi, Nabi Shariatifar, Seyed Hooman Mirbaha, Behrokh Marzban Abbasabadi, Saeed Samarghandian, Tahereh Farkhondeh and Parisa Sadighara*

Inhibitory Effect of Artemisinin on Testosterone Propionate Induced Benign Prostatic Hyperplasia

Volume:17
Ayushi Solanki, Sandip Patel*, Nilay Solanki and Umang Shah

β-D-Mannuronic Acid (M2000) as a Landmark in Pharmacology

Volume:17
Nada A. G. Gaafar, A. Razavi and Abbas Mirshafiey*

Immunomodulatory Effects of Medicinal Plants used for Vitiligo in Traditional Persian Medicine

Volume:17
Mohsen Haghir Ebrahimabadi, Seyede Nargess Sadati Lamardi and Laila Shirbeigi*

Effect of Nectaroscordum koelzi Methanolic Extract on Acute and Chronic Inflammation in Male Mice

Volume:17
Karam Hossein Hasanvand, Mojtaba Khaksarian, Maryam Alipour, Hormoz Mahmoudvand, Massumeh Naizi and Sedighe Nadri*

Anti-candida Activity of Curcumin: A Review

Volume:17
Kourosh Cheraghipour*, Behrouz Ezatpour, Leila Masoori, Abdolrazagh Marzban, Asghar Sepahvand, Arian Karimi Rouzbahani, Abbas Moridnia, Sayyad Khanizadeh and Hossein Mahmoudvand

Punica granatum as a Source of Natural Antioxidant and Antimicrobial Agent; a Comprehensive Review on Related Investigations

Volume:17
Atefeh Jalali, Mohammadreza Kiafar, Masih Seddigh and Mohammad M. Zarshenas*

An Evidence-Based Review of Antitussive Herbs Containing Essential Oils in Traditional Persian Medicine

Volume:17
Ayda Hosseinkhani, Bijan Ziaeian, Kamran Hessami, Mohammad Mehdi Zarshenas, Ali Kashkooe and Mehdi Pasalar*

In Silico Analysis, Synthesis, and Biological Evaluation of Triazole Derivatives as H1 Receptor Antagonist

Volume:17
Sandip N Badeliya, Ishan I Panchal*, Bibhranjan Panigrahi and C. N. Patel

An Evidence-based Review of Medicinal Plants used in Traditional Persian Medicine for Treatment of Osteoarthritis

Volume:17
Soodeh Karami, Shiva Shamshiri, Mohammad Abdollahi and Roja Rahimi *

In silico-based Approach to Investigate the Ability of PEGylated Rapamycin to Inhibit Galectin-3

Volume:17
Marwan Abdelmahmoud Abdelkarim Maki, Palanirajan Vijayaraj Kumar*, Manogaran Elumalai and Omer Bayazeid

An Analysis of QSAR Research Based on Machine Learning Concepts

Volume:17
Mohammad Reza Keyvanpour* and Mehrnoush Barani Shirzad

Traditional Aspects of Sciatic Pain Management and Allied Therapies from Persian Medical Reports

Volume:17
Ramin Ansari, Amirhossein Dadbakhsh, Fatemeh Hasani, Fatemeh Hosseinzadeh, Zohreh Abolhassanzadeh and Mohammad M. Zarshenas*

A Review of Pharmacological Properties and Toxicological Effects of Adiantum Capillus-veneris L.

Volume:17
Ali Kashkooe, Frough Afsari Sardari, Mahkameh Moradi Mehrabadi and Mohammad M. Zarshenas*

Evaluation of Diuretic and Antioxidant Properties in Aqueous Bark and Fruit Extracts of Pine

Volume:17
Hadi Shariati, Mohammad Hassanpour, Gholamreza Sharifzadeh, Asghar Zarban*, Saeed Samarghandian and Farhad Saeedi

Syringic Acid: A Potential Natural Compound for the Management of Renal Oxidative Stress and Mitochondrial Biogenesis in Diabetic Rats

Volume:17
Marzieh Rashedinia , Mohammad Javad Khoshnoud, Bahman khalvati Fahlyan , Seyedeh-Sara Hashemi, Mahshid Alimohammadi and Zahra Sabahi*

Structural And Computational Perspectives of Selectively Targeting Mutant Proteins

Volume:17
Mathew Coban, Sarah Fraga and Thomas Caulfield*

An Evidence-Based Research on Botanical Sources for Oral Mucositis Treatment in Traditional Persian Medicine

Volume:17
Fatemeh Sadat Hasheminasab, Fariba Sharififar, Seyed Mehdi Hashemi and Mohammad Setayesh*

Efficacy of Honey-based Ophthalmic Formulation in Patients with Corneal Ulcer: A Randomized Clinical Trial

Volume:17
Mahmood Nejabat, Kazem Soltanzadeh, Masoud Yasemi, Saeid Daneshamouz, Amin Reza Akbarizadeh and Mojtaba Heydari*

Evaluation of Ficus retusa L. Leaves with Special Reference to Antidiarrheal and Anti-spasmodic Activity

Volume:17
Najam Ali Khan*, Chitra Tomar, Alankar Shrivastav, Aftab Ahmad and Arun Kumar Mishra

Formulation, Standardization, and a Preliminary Before-After Clinical Trial on Effect of a Traditional Herbal Formula (Maqliasa) on Manifestations of Ulcerative Colitis

Volume:17
Meysam Shirzad, Mohammad Mahdi Ahmadian-Attari, Seyed Mohammad Sadegh Ghafoori, Leila Mohammad Taghizadeh Kashani , Mehdi Pasalar, Alireza Abbassian and Shahram Agah *

Pharmacological Applications of Phlorotannins: A Comprehensive Review

Volume:17
Ahsan Javed*, Muhammad Bilal Hussain, Ali Tahir, Marwa Waheed, Ahsan Anwar, Mohammad Ali Shariati, Sergey Plygun, Alexey Laishevtcev and Mehdi Pasalar*

The Potential Role of Tea in Periodontal Therapy: An Updated Review

Volume:17
Ali Forouzanfar, Hamideh Sadat Mohammadipour and Fatemeh Forouzanfar*

Alcoholic and Non-Alcoholic Liver Diseases: Promising Molecular Drug Targets and their Clinical Development

Volume:17
Komal Thapa, Ajmer Singh Grewal*, Neha Kanojia, Lata Rani, Neelam Sharma and Sukhbir Singh

Moringa Oleifera in Malnutrition: A Comprehensive Review

Volume:16
Bilal Sajid Mushtaq*, Muhammad Bilal Hussain, Rabia Omer, Hafiz Ahmad Toor, Marwa Waheed, Mohammad Ali Shariati, Plygun Sergey and Mojtaba Heydari

Insights into the FDA 2018 New Drug Approvals

Volume:16
Alaa Bedair and Fotouh R. Mansour*

Medicinal Plants in the Treatment of Obsessive-Compulsive Disorder: A Review

Volume:16
Ali Talaei, Fatemeh Forouzanfar* and Shahin Akhondzadeh

Influence of β-D-mannuronic Acid, As a New Member of Non-steroidal Anti- Inflammatory Drugs Family, on the Expression Pattern of Chemokines and their Receptors in Rheumatoid Arthritis

Volume:16
Mona Aslani, Arman Ahmadzadeh, Zahra Aghazadeh, Majid Zaki-Dizaji, Laleh Sharifi, Mostafa Hosseini and Abbas Mirshafiey*

Kaempferol as a Potential PAK4 Inhibitor in Triple Negative Breast Cancer: Extra Precision Glide Docking and Free Energy Calculation

Volume:16
Michael A. Arowosegbe*, Oluwamuyiwa T. Amusan, Segun A. Adeola, Oluwatosin B. Adu, Israel A. Akinola, Bimpe F. Ogungbe, Olaposi I. Omotuyi, Gbemisola M. Saibu, Adewale J. Ogunleye, Ramon I. Kanmodi, Nekabari E. Lugbe, Oluwafemi J. Ogunmola, Damilola C. Ajayi, Sedoten O. Ogun, Faith O. Oyende, Ahmed O. Bello, Abudulmalik O. Ishola and Patrick E. Obasieke

Targeting Small Molecule Tyrosine Kinases by Polyphenols: New Move Towards Anti-tumor Drug Discovery

Volume:16
Nikhil S. Sakle, Shweta A. More, Sachin A. Dhawale and Santosh N. Mokale*

Interaction with Modified Cyclodextrin as a Way to Increase the Antimalarial Activity of Primaquine

Volume:16
Liliane Henrique Torres, Lucas Bragança de Carvalho, Adneia de Fátima Abreu Venceslau, Carlos Jaime and Luciana de Matos Alves Pinto*

Large-scale High-throughput Screening Revealed 5'-(carbonylamino)-2,3'- bithiophene-4'-carboxylate as Novel Template for Antibacterial Agents

Volume:16
Yan A. Ivanenkov, Renat S. Yamidanov, Ilya A. Osterman, Petr V. Sergiev, Vladimir A. Aladinskiy, Anastasia V. Aladinskaya, Victor A. Terentiev, Mark S. Veselov, Andrey A. Ayginin, Dmitry A. Skvortsov, Katerina S. Komarova, Bogdan A. Zagribelnyy*, Alexey Kh. Baimiev, Kseniya Yu. Shvetc, Andrey Kh. Baimiev, Alina A. Sofronova, Alexey E. Machulkin, Rostislav A. Petrov, Liana F. Zainullina, Marina A. Maximova, Zulfiya R. Zileeva, Yulia V. Vakhitova, Dmitry S. Bezrukov, Maria M. Puchinina and Olga A. Dontsova

The Effect of Viola Odorata L. Oil for Fever in Children: A Randomized Triple-blinded Placebo-controlled Clinical Trial

Volume:16
Vahid Tafazoli, Mahdi Shahriari, Mojtaba Heydari, Hosein Ali Nikbakht, Mohammad Mahdi Zarshenaas and Majid Nimrouzi*

Photochemical /Photocytotoxicity Studies of New Tetrapyrrolic Structures as Potential Candidates for Cancer Theranostics

Volume:16
L. F. Vieira Ferreira *, I. Ferreira Machado, A. Gama, R. P. Socoteanu, R. Boscencu, G. Manda, R. C. Calhelha and I. C.F.R. Ferreira

Drug Stereochemistry: A Prodigy For Pharmacology and Drug Development

Volume:16
Karan Gandhi, Umang Shah* and Sandip Patel

Design, Synthesis and Anticancer Activity of Site Specific Short Chain Cationic Peptide

Volume:16
Ravi Dutt Sharma*, Jainendra Jain and Ratan Lal Khosa

Biological Significance of Imidazole-based Analogues in New Drug Development

Volume:16
Pratiksha Nishant Chopra and Jagdish Kumar Sahu*