Current Drug Discovery Technologies

In Silico Inhibition of BACE-1 by Selective Phytochemicals as Novel Potential Inhibitors: Molecular Docking and DFT Studies

Volume:17   Issue:3
Pp: 397-411
Nadia Arif, Andleeb Subhani, Waqar Hussain and Nouman Rasool*
DOI: 10.2174/1570163816666190214161825

Mechanisms of Antimicrobial Resistance (AMR) and Alternative Approaches to Overcome AMR

Volume:17   Issue:4
Pp: 430-447
Chew-Li Moo, Shun-Kai Yang, Khatijah Yusoff, Mokrish Ajat, Warren Thomas, Aisha Abushelaibi, Swee-Hua-Erin Lim and Kok-Song Lai*
DOI: 10.2174/1570163816666190304122219

From Target Identification to Drug Development in Space: Using the Microgravity Assist

Volume:17   Issue:1
Pp: 45-56
Martin Braddock*
DOI: 10.2174/1570163816666190112150014

Do We have a Satisfactory Cell Viability Assay? Review of the Currently Commercially-Available Assays

Volume:17   Issue:1
Pp: 2-22
Abdel-Baset Halim*
DOI: 10.2174/1570163815666180925095433

Novel Approaches to Anti-atherosclerotic Therapy: Cell-based Models and Herbal Preparations (Review of Our Own Data)

Volume:17   Issue:3
Pp: 278-285
Alexander N. Orekhov*, Andrey V. Grechko, Elena B. Romanenko, Dongwei Zhang and Dimitry A. Chistiakov
DOI: 10.2174/1570163816666190101112241

The Effect of Resveratrol dose and Duration of Treatment on Blood Pressure in Patients with Cardiovascular Disorders: A Systematic Review

Volume:17   Issue:3
Pp: 325-331
Fahimeh D. Mashhadi, Roshanak Salari and HamidReza Ghorbanzadeh*
DOI: 10.2174/1570163816666190226100812

Biological Significance of Imidazole-based Analogues in New Drug Development

Volume:17   Issue:5
Pp: 574-584
Pratiksha N. Chopra and Jagdish K. Sahu*
DOI: 10.2174/1570163816666190320123340

The Role of Anthocyanins in Drug Discovery: Recent Developments

Volume:17   Issue:3
Pp: 286-298
Marco Bonesi*, Mariarosaria Leporini, Maria C. Tenuta and Rosa Tundis
DOI: 10.2174/1570163816666190125152931

Long-term Stabilization of Aqueous Doxycycline Formulations, in Mucoadhesive Hydrogels for Treatment of Oral Mucosal Conditions

Volume:17   Issue:3
Pp: 376-386
Venu G.R. Patlolla, William P. Holbrook, Sveinbjorn Gizurarson* and Thordis Kristmundsdottir
DOI: 10.2174/1570163816666190222193902

Nanoparticles and Its Implications in HIV/AIDS Therapy

Volume:17   Issue:4
Pp: 448-456
Victor B. Oti*
DOI: 10.2174/1570163816666190620111652

Synthesis, Characterization and Antimicrobial Evaluation of Some N-Substituted Benzimidazole Derivatives

Volume:17   Issue:1
Pp: 87-91
Anuj Kumar, Yogesh Kumar, Jagdish K. Sahu* and Sushil Kumar
DOI: 10.2174/1570163815666180831164149

Effect of Geographical Location and Type of Extract on Total Phenol/Flavon Contents and Antioxidant Activity of Different Fruits Extracts of Withania somnifera

Volume:17   Issue:1
Pp: 92-99
Lokesh Adhikari, Rupali Kotiyal, Mukesh Pandey, Meenakshi Bharkatiya, Ajay Sematy and Mona Semalty*
DOI: 10.2174/1570163815666180807100456

Identification and Ranking of Clinical Compounds with Activity Against Log-phase Growing Uropathogenic Escherichia coli

Volume:17   Issue:2
Pp: 191-196
Hongxia Niu, Rebecca Yee, Peng Cui, Shuo Zhang, Lili Tian, Wanliang Shi, David Sullivan, Bingdong Zhu, Wenhong Zhang and Ying Zhang *
DOI: 10.2174/1570163815666180808115501

Investigation on Quantitative Structure-Activity Relationships of 1,3,4-Oxadiazole Derivatives as Potential Telomerase Inhibitors

Volume:17   Issue:1
Pp: 79-86
Marco Tutone*, Beatrice Pecoraro and Anna M. Almerico
DOI: 10.2174/1570163815666180724113208

The Effect of Viola Odorata L. Oil for Fever in Children: A Randomized Triple-blinded Placebo-controlled Clinical Trial

Volume:17   Issue:5
Pp: 696-703
Vahid Tafazoli, Mahdi Shahriari, Mojtaba Heydari, Hosein Ali Nikbakht, Mohammad M. Zarshenaas and Majid Nimrouzi*
DOI: 10.2174/1570163816666190620142256

Kaempferol as a Potential PAK4 Inhibitor in Triple Negative Breast Cancer: Extra Precision Glide Docking and Free Energy Calculation

Volume:17   Issue:5
Pp: 682-695
Michael A. Arowosegbe*, Oluwamuyiwa T. Amusan, Segun A. Adeola, Oluwatosin B. Adu, Israel A. Akinola, Bimpe F. Ogungbe, Olaposi I. Omotuyi, Gbemisola M. Saibu, Adewale J. Ogunleye, Ramon I. Kanmodi, Nekabari E. Lugbe, Oluwafemi J. Ogunmola, Damilola C. Ajayi, Sedoten O. Ogun, Faith O. Oyende, Ahmed O. Bello, Peter G. Ishola and Patrick E. Obasieke
DOI: 10.2174/1570163816666190823135948

Modulation of Gut Microbiota through Dietary Phytochemicals as a Novel Anti-infective Strategy

Volume:17   Issue:4
Pp: 498-506
Pavan K. Mujawdiya and Suman Kapur*
DOI: 10.2174/1570163816666191107124214

Exploring Antimicrobials from the Flora and Fauna of Marine: Opportunities and Limitations

Volume:17   Issue:4
Pp: 507-514
Krishnamoorthy Venkateskumar, Subramani Parasuraman*, Leow Y. Chuen, Veerasamy Ravichandran and Subramani Balamurgan
DOI: 10.2174/1570163816666190819141344

Antimicrobial Peptides: An Approach to Combat Resilient Infections

Volume:17   Issue:4
Pp: 542-552
Debaprasad Parai*, Pia Dey and Samir K. Mukherjee
DOI: 10.2174/1570163816666190620114338

Discovery and Development of Novel Anti-fungal Peptides Against Foodspoiling Fungi

Volume:17   Issue:4
Pp: 553-561
Belal J. Muhialdin*, Hussein L. Algboory, Nameer K. Mohammed, Hana Kadum, Anis S.M. Hussin, Nazamid Saari and Zaiton Hassan
DOI: 10.2174/1570163816666190715120038

Novel Nanotherapeutics as Next-generation Anti-infective Agents: Current Trends and Future Prospectives

Volume:17   Issue:4
Pp: 457-468
Pattnaik Subhaswaraj, Asad Syed and Busi Siddhardha*
DOI: 10.2174/1570163816666190715120708

In Vitro Protective Effect of Ascorbic Acid Against Antibiotic-Induced Hepatotoxicity

Volume:17   Issue:3
Pp: 357-364
Veneta Simon, Sreerag K.V., R. Sasikumar and S.K. Kanthlal*
DOI: 10.2174/1570163816666190204122007

A Definitive Pharmacophore Modelling Study on CDK2 ATP Pocket Binders: Tracing the Path of New Virtual High-Throughput Screenings

Volume:17   Issue:5
Pp: 740-747
Marco Tutone*, Giulia Culletta, Luca Livecchi and Anna M. Almerico
DOI: 10.2174/1570163816666190620113944

Therapeutic Aspects of Squill; An Evidence-Based Review

Volume:17   Issue:3
Pp: 318-324
Khadije Saket, Jalil T. Afshari, Ehsan Saburi, Mahdi Yousefi and Roshanak Salari*
DOI: 10.2174/1570163816666190125154745

Antimicrobial Activity of Agarwood Oil Against Multiple-Drug-Resistant (MDR) Microbes of Clinical, Food and Environmental Origin

Volume:17   Issue:3
Pp: 348-356
Bhoj R. Singh*, Dharmendra K. Sinha, Vinodh K. OR, Prasanna Vadhana, Monika Bhardwaj, Archana Saraf, Sakshi Dubey, Abhijit M Pawde, Ujjwal K. De and Vinod K. Gupta
DOI: 10.2174/1570163816666190125163536