Abstract
The development, refinement and increasingly widespread use of high-density DNA microarrays have been important responses to the explosion of sequence information produced by genome science. Principal among the application of microarrays is the large-scale analysis of gene expression, often referred to as expression profiling. The power of this application lies in its ability to determine the expression patterns of thousands of genes in a single experiment. Microarray use is becoming widespread in many biomedical research fields, including the study of carcinogenesis, in which expression profiling has found a number of important applications. Broadly speaking, these applications can be described as gene and pathway discovery, gene functional assignment, and tumor classification. A number of early gene expression studies using tumor cell lines and tumors have shown that DNA microarrays are powerful tools, both for identifying new genes and assigning roles to known genes involved in carcinogenesis as well as for classifying tumors subtypes. In this review, we describe the major types of DNA microarrays, discuss some practical considerations for their use, and present examples of how they are being applied to the investigation of cancer.
Keywords: dna microarray, oligonucleotide microarray
Current Genomics
Title: The Application of DNA Microarrays to the Study of Cancer
Volume: 3 Issue: 4
Author(s): K. Harshman and M. Sanchez-Carbayo
Affiliation:
Keywords: dna microarray, oligonucleotide microarray
Abstract: The development, refinement and increasingly widespread use of high-density DNA microarrays have been important responses to the explosion of sequence information produced by genome science. Principal among the application of microarrays is the large-scale analysis of gene expression, often referred to as expression profiling. The power of this application lies in its ability to determine the expression patterns of thousands of genes in a single experiment. Microarray use is becoming widespread in many biomedical research fields, including the study of carcinogenesis, in which expression profiling has found a number of important applications. Broadly speaking, these applications can be described as gene and pathway discovery, gene functional assignment, and tumor classification. A number of early gene expression studies using tumor cell lines and tumors have shown that DNA microarrays are powerful tools, both for identifying new genes and assigning roles to known genes involved in carcinogenesis as well as for classifying tumors subtypes. In this review, we describe the major types of DNA microarrays, discuss some practical considerations for their use, and present examples of how they are being applied to the investigation of cancer.
Export Options
About this article
Cite this article as:
Harshman K. and Sanchez-Carbayo M., The Application of DNA Microarrays to the Study of Cancer, Current Genomics 2002; 3 (4) . https://dx.doi.org/10.2174/1389202023350372
DOI https://dx.doi.org/10.2174/1389202023350372 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Advanced Computational Algorithms and Artificial Intelligence in Clinical Pharmacogenomics
In the era of personalized medicine, understanding the relationship between genetics and drug response is crucial. This issue delves into innovative methodologies, leveraging deep computational analysis and artificial intelligence, to enhance the field of Clinical Pharmacogenomics. The interdisciplinary approach harnesses the power of advanced high-throughput genotyping technologies, sophisticated computational analysis, ...read more
Applications of Single-cell Sequencing Technology in Reproductive Medicine
Single cell sequencing (SCS) technology utilizes individual cells' genetic material to sequence their genome, transcriptome, and epigenetics at the molecular level. It offers insights into cell heterogeneity and enables the study of limited biological materials. Since its recognition as a valuable technique in 2011, single cell sequencing has yielded numerous ...read more
Big Data in Cancer Research
Cancer is a significant threat to human life and health, remaining a highly aggressive killer. It is a leading cause of death worldwide and represents a crucial medical issue for humanity. However, in the past decade, the effectiveness of new synthetic anticancer agents has not matched the current clinical speculation. ...read more
Current Genomics in Cardiovascular Research
Cardiovascular diseases are the main cause of death in the world, in recent years we have had important advances in the interaction between cardiovascular disease and genomics. In this Research Topic, we intend for researchers to present their results with a focus on basic, translational and clinical investigations associated with ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Computed Tomography (CT) Features of Pelvic Rhabdomyosarcoma
(RMS) in Children
Current Medical Imaging B7-H3-targeted Radioimmunotherapy of Human Cancer
Current Medicinal Chemistry Potential Therapeutic Targets of Curcumin, Most Abundant Active Compound of Turmeric Spice: Role in the Management of Various Types of Cancer
Recent Patents on Anti-Cancer Drug Discovery Anti-cancer and Anti-angiogenic Properties of Various Natural Pentacyclic Tri-terpenoids and Some of their Chemical Derivatives
Current Organic Chemistry Antiproliferative and Proapoptotic Effects of the TrK-inhibitor GW441756 in Human Myosarcomas and Prostatic Carcinoma
Current Signal Transduction Therapy The Current and Future Therapies for Human Osteosarcoma
Current Cancer Therapy Reviews TWIST1 Gene: First Insights in Felis catus
Current Genomics Targeting Drugs Against Fibroblast Growth Factor(s)-Induced Cell Signaling
Current Drug Targets Fungal Proteins with Antiproliferative and Anticancer Activities
Protein & Peptide Letters Oncolytic Viruses: Programmable Tumour Hunters
Current Gene Therapy Botanical Therapeutics (Part II): Antimicrobial and In Vitro Anticancer Activity against MCF7 Human Breast Cancer Cells of Chamomile, Parsley and Celery Alcoholic Extracts
Anti-Cancer Agents in Medicinal Chemistry Tumor-related Molecular Regulatory Mechanisms of Long Non-coding RNA RMST: Recent Evidence
Mini-Reviews in Medicinal Chemistry Target-oriented Mechanisms of Novel Herbal Therapeutics in the Chemotherapy of Gastrointestinal Cancer and Inflammation
Current Pharmaceutical Design Antibodies as Crypts of Antiinfective and Antitumor Peptides
Current Medicinal Chemistry Dendritic Cell Immunotherapy for Malignant Gliomas
Reviews on Recent Clinical Trials Functional Evaluation of an Ectopic Supernumerary Kidney in Pelvis
Current Medical Imaging Mining Sarcomas by Proteomics Approaches: Ewing Sarcoma on the Spotlight
Recent Patents on Biotechnology Transcription Factors in Heart: Promising Therapeutic Targets in Cardiac Hypertrophy
Current Cardiology Reviews Clinical Considerations of Focal Drug Delivery in Cancer Treatment
Current Drug Delivery Zebrafish: A Complete Animal Model for In Vivo Drug Discovery and Development
Current Drug Metabolism