Abstract
Clinical use of non-steroidal anti-inflammatory drugs (NSAIDs) is associated with significant toxicity particularly in the gastrointestinal tract and kidney. Various approaches such as formulation & co-administration (of agents to protect the stomach), chemical manipulation and synthesis of new safer anti-inflammatory drugs reported in the literature to overcome the toxicity of NSAIDs have been summarized. As far as synthesis of new more effective and safer anti-inflammatory drugs is concerned, we have reported recent findings in the area of synthesis of heterocyclic compounds such as pyrimidines, imidazole, benzimidazole, thiazole, thiazolidine, acridine, thiourea, alkanoic acid derivatives and other related heterocyclic compounds and their role as inflammation inhibitors.
Keywords: Heterocyclic compounds, Inflammation inhibitors, nonsteroidal
Current Medicinal Chemistry
Title: Heterocyclic Compounds as Inflammation Inhibitors
Volume: 9 Issue: 10
Author(s): Sham M. Sondhi, Nidhi Singhl, Monika Johar, B.S. Narayan Reddy and J. William Lown
Affiliation:
Keywords: Heterocyclic compounds, Inflammation inhibitors, nonsteroidal
Abstract: Clinical use of non-steroidal anti-inflammatory drugs (NSAIDs) is associated with significant toxicity particularly in the gastrointestinal tract and kidney. Various approaches such as formulation & co-administration (of agents to protect the stomach), chemical manipulation and synthesis of new safer anti-inflammatory drugs reported in the literature to overcome the toxicity of NSAIDs have been summarized. As far as synthesis of new more effective and safer anti-inflammatory drugs is concerned, we have reported recent findings in the area of synthesis of heterocyclic compounds such as pyrimidines, imidazole, benzimidazole, thiazole, thiazolidine, acridine, thiourea, alkanoic acid derivatives and other related heterocyclic compounds and their role as inflammation inhibitors.
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Cite this article as:
Sondhi M. Sham, Singhl Nidhi, Johar Monika, Reddy Narayan B.S. and Lown William J., Heterocyclic Compounds as Inflammation Inhibitors, Current Medicinal Chemistry 2002; 9 (10) . https://dx.doi.org/10.2174/0929867024606678
DOI https://dx.doi.org/10.2174/0929867024606678 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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